Results 191 to 200 of about 3,384,133 (256)

From the Proteome to Therapeutics: A Multi‐Database Approach to Drug Discovery in Periodontitis—An Exploratory Pilot Study

Journal of Clinical Periodontology, Volume 53, Issue 7, Page 990-1004, July 2026.
ABSTRACT Introduction This explanatory pilot study presents a workflow to identify approved drugs, which could be repurposed for periodontitis therapy using salivary proteomics combined with drug‐target database screening. Methods Proteomic analyses of saliva using LC–MS/MS were conducted in two independent settings: a cohort (sub‐study I, N = 187) and
Taisir Bozo, Annette Murr, Birte Holtfreter, Sebastian‐Edgar Baumeister, Peter Meisel, Uwe Völker, Werner Weitschies, Henry Völzke, Philipp Kanzow, Elke Hammer, Manuela Gesell Salazar, Thomas Kocher   +11 more
wiley   +1 more source

Nanoromidepsin, a polymer nanoparticle of the HDAC inhibitor, improves safety and efficacy in models of T-cell lymphoma.

Blood
Pal I, Illendula A, Joyner A, Manavalan JS, Deddens TM, Sabzevari A, Damera DP, Zuberi S, Marchi E, Fox TE, Dunlap-Brown ME, Jayappa KD, Khalife J, Craig JW, Loughran TP, Feith DJ, O'Connor OA.   +16 more
europepmc   +1 more source

HDAC inhibitor (SAHA) enhances B7-H3-specific CAR T cell cytotoxic efficacy against chondrosarcoma cells and prolongs survival in an orthotopic mouse model. [PDF]

Transl Oncol
Osei-Hwedieh DO, He L, Wang K, Fan S, Ferrone S, Wang X, Schwab JH.   +6 more
europepmc   +1 more source

Endophyte‐induced systemic spatial reprogramming of metabolism in Populus trichocarpa roots under drought

New Phytologist, Volume 251, Issue 1, Page 438-454, July 2026.
Summary Beneficial, facultative endophytes help plants thrive in challenging environments by altering their host's metabolism, but how these cellular scale metabolic changes propagate to the systems biology scale is unknown. In this work, we employed a high‐resolution chemical imaging approach to map metabolic changes at the Populus trichocarpa root ...
Jayde Aufrecht, Dušan Veličković, Robert Tournay, Sneha Couvillion, Vimal Balasubramanian, Tanya Winkler, Daisy Herrera, Robert Stanley, Sharon L. Doty, Amir H. Ahkami   +9 more
wiley   +1 more source

Combination of HDAC inhibitor and PI3K inhibitor suppresses autophagy and induces apoptosis via cytoplasmic IκBα stabilization in p53-mutant diffuse large B-cell lymphoma. [PDF]

Cell Death Discov
Yao J, Li M, Jiang Y, Yao N, Liu Y, Lv L, Li Y, Huang J, Zha J, Xu B.   +9 more
europepmc   +1 more source

Mapping Functionally Relevant Tractable Lysines of Challenging Protein Targets by Covalent Fragment Screening

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Screening a lysine‐targeting covalent fragment library against challenging protein targets revealed suitable warheads and characterized binding sites for the development of targeted covalent ligands. Covalent fragment screening has become an established strategy for identifying targetable amino acid residues or viable chemical starting points against ...
Noémi Csorba, Péter Ábrányi‐Balogh, Zoltán Orgován, Tibor Viktor Szalai, György G. Ferenczy, Levente Kollár, Nikolett Péczka, Tímea Imre, József Simon, Pál Szabó, Gitta Schlosser, Martina Hrast, Stanislav Gobec, Varbina Ivanova, Carles Galdeano, Aleksandra Kopranovic, Marc Neumann, Franz‐Josef Meyer‐Almes, György Miklós Keserű   +18 more
wiley   +1 more source

HDAC inhibitor tucidinostat and metronomic capecitabine plus endocrine therapy for patients with HR-positive HER2-negative advanced breast cancer after CDK4/6 inhibitors treatment: clinical findings and exploratory circulating tumor cell and ctDNA biomarker analyses of a multicenter, phase 2 study (SYSUCC-020 trial). [PDF]

Signal Transduct Target Ther
Wu HL, Xia W, Xu Z, Zhou H, Chen L, Lu Y, Liu X, Pang D, Liu Y, Lu Q, Xu F, An X, Huang J, Jiang K, Zhang J, Cai Y, Hong R, Zheng Q, Wang S.   +18 more
europepmc   +1 more source

ID3 deficiency alters chromatin accessibility at DSB sites and enhances vulnerability to HDAC inhibition

International Journal of Cancer, Volume 158, Issue 12, Page 3173-3186, 15 June 2026.
What's new? Errors in DNA double‐strand break (DSB) repair can lead to mutations, chromosomal instability, and ultimately cancer. Inhibitor of DNA‐binding 3 (ID3), a transcriptional repressor, is crucial to promoting DSB repair and helping maintain genome stability. Here, the authors investigated ID3 regulation of DNA repair via chromatin accessibility
Giuditta Della Corte, Hossam Eldesouky, Julia Puchan, Sercan Öz, Elena Everatt, Ashish Goyal, Gianluca Sigismondo, Udo Oppermann, Christoph Plass, Dieter Weichenhan, Ali Bakr   +10 more
wiley   +1 more source

Cutaneous T-Cell Lymphoma: Yin-Yang Effects of Transcription Factors HLF and NFIL3 in Regulation of Malignant T-Cell Markers in the Context of HDAC Inhibitor Romidepsin Treatment. [PDF]

Cancers (Basel)
Kossenkov AV, Dawany N, Majumdar S, Chang C, Nichols C, Wysocka M, Piekarz R, Showe MK, Bates SE, Rook AH, Kim EJ, Showe LC.   +11 more
europepmc   +1 more source