Results 221 to 230 of about 3,384,133 (256)

Single‐Cell RNA Sequencing Informs Precision Targeting of Monogenic Lupus Associated With IKZF1 Haploinsufficiency

Arthritis &Rheumatology, Volume 78, Issue 6, Page 1231-1244, June 2026.
Objective This study aimed to investigate the mechanisms of immune dysregulation in a pediatric patient with monogenic lupus driven by IKZF1 haploinsufficiency. Methods Peripheral immune cells from a patient with IKZF1 haploinsufficiency, patients with lupus with no currently known genetic mutations, and healthy controls were analyzed using single‐cell
Qi Zheng, Yejun Tan, Zhaoling Wang, Yanjie Qian, Qian Ma, Danping Shen, Meiping Lu   +6 more
wiley   +1 more source

Gut Microbiome–Sleep Crosstalk: Mechanistic Pathways, Dysbiosis Signatures, and Microbiome‐Based Interventions

Brain and Behavior, Volume 16, Issue 6, June 2026.
Gut dysbiosis and sleep disturbances interact bidirectionally through microbial metabolites, immune activation, and neuroendocrine signaling along the gut–brain axis. Microbiome‐based interventions, including probiotics, prebiotics, synbiotics, postbiotics, and fecal microbiota transplantation, may help improve sleep quality and reduce inflammatory ...
Ghaleb Oriquat, Shaker Al‐Hasnaawei, Hayjaa Mohaisen Mousa, Malathi H, Siya Singla, Samir Sahoo, Vimal Arora, Ashish Singh Chauhan, Mehrdad Nourizadeh   +8 more
wiley   +1 more source

IHCH9033, a novel class I HDAC inhibitor, synergizes with FLT3 inhibitor and rescues quizartinib resistance in FLT3-ITD AML via enhancing DNA damage response. [PDF]

Exp Hematol Oncol
Yao M, Yan W, Wang Y, Zhao Y, Xu X, Chen Y, Yu C, Li Y, Jiang H, Shen J, Cheng J, Xie C.   +11 more
europepmc   +1 more source

Correction: The HDAC inhibitor, MPT0E028, enhances erlotinib induced cell death in EGFR-TKI-resistant NSCLC cells. [PDF]

Cell Death Dis
Chen M-, Chen C-, Wang J-, Tsai A-, Liou J-, Pan S-, Teng C-.   +6 more
europepmc   +1 more source

Class IIa histone deacetylase (HDAC) inhibitor TMP269 suppresses lumpy skin disease virus replication by regulating host lysophosphatidic acid metabolism. [PDF]

J Virol
Cheng P, Wang X, Wang S, Ren S, Liang Z, Guo K, Qu M, Meng X, Dou Y, Yin X, Sun Y.   +10 more
europepmc   +1 more source

Histone deacetylase (HDAC) inhibitor specificity determinants are preserved in a class of dual HDAC/non-covalent proteasome inhibitors. [PDF]

Bioorg Med Chem
Chan AM, Mitchell A, Grogan L, Shapiro P, Fletcher S.   +4 more
europepmc   +1 more source

HDAC1 acts as tumor suppressor in ALK-positive anaplastic large-cell lymphoma: Implications for HDAC inhibitor therapy

Zrimšek M, Draganić K, Malzer A, Doblmayr V, de Freitas e Silva R, Wohlhaupter S, Perez Malla CU, Mišura K, Fischer H, Schachner H, Schiefer A, Sheibani-Tezerji R, Ellmeier W, Seiser C, Egger G.   +14 more
europepmc   +1 more source

HDAC inhibitor derivatives induce differentiation of leukemic cells through two distinct and separable mechanisms

Kumar P, Josa-Culleré L, Jackson TR, Bataille CJR, Vyas P, Milne TA, Russell AJ.   +6 more
europepmc   +1 more source