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Bioorganic Chemistry, 2019
DNMT and HDAC are closely related to each other and involved in various human diseases especially cancer. These two enzymes have been widely recognized as antitumor targets for drug discovery.
Zigao Yuan +2 more
exaly +2 more sources
DNMT and HDAC are closely related to each other and involved in various human diseases especially cancer. These two enzymes have been widely recognized as antitumor targets for drug discovery.
Zigao Yuan +2 more
exaly +2 more sources
Expert Opinion on Drug Discovery, 2021
Introduction HDACs catalyze the removal of acetyl groups from the ε-N-acetylated lysine residues of various protein substrates including both histone and nonhistone proteins.
Ma Su, Xing-Yu Gong, Feng Liu
semanticscholar +1 more source
Introduction HDACs catalyze the removal of acetyl groups from the ε-N-acetylated lysine residues of various protein substrates including both histone and nonhistone proteins.
Ma Su, Xing-Yu Gong, Feng Liu
semanticscholar +1 more source
PharmaceuticalsPancreatic ductal adenocarcinoma (PDAC) is the most lethal form of pancreatic cancer characterized by therapy resistance and early metastasis, resulting in a low survival rate.
Marc Pflieger +2 more
exaly +3 more sources
HDAC/MIF dual inhibitor inhibits NSCLC cell survival and proliferation by blocking the AKT pathway
Bioorganic Chemistry, 2021Fangyuan Cao +2 more
exaly
LPIN1 downregulation enhances anticancer activity of the novel HDAC/PI3K dual inhibitor FK‐A11
Cancer Science, 2021Hiroo Imai +2 more
exaly
Curcumin: A Natural Pan-HDAC Inhibitor in Cancer.
Current pharmaceutical design, 2018Sara Saffar Soflaei +5 more
semanticscholar +1 more source