Results 301 to 310 of about 2,934,766 (329)

An Overview of HDAC Inhibitors and their Synthetic Routes.

Current Topics in Medicinal Chemistry, 2019
Epigenetics play a key role in the origin, development and metastasis of cancer. Epigenetic processes include DNA methylation, histone acetylation, histone methylation, and histone phosphorylation, among which, histone acetylation is the most common one ...
Xiaopeng Peng, Guochao Liao, Pinghua Sun, Zhiqiang Yu, Jianjun Chen   +4 more
semanticscholar   +1 more source

HDAC Inhibitors and Chaperone Function

2012
Cellular chaperones promote the folding and maturation of newly synthesized proteins and partially folded proteins in the cytosol and endoplasmic reticulum (ER) as well as prevent the aggregation of misfolded proteins. Histone deacetylases (HDACs) and histone acetyl transferases catalyze the reversible acetylation of histones and nonhistone substrates ...
Rekha, Rao, Warren, Fiskus, Siddhartha, Ganguly, Suman, Kambhampati, Kapil N, Bhalla   +4 more
openaire   +2 more sources

An updated patent review of histone deacetylase (HDAC) inhibitors in cancer (2020 – present)

Expert Opinion on Therapeutic Patents, 2023
Yi-Min Liu, J. Liou
semanticscholar   +1 more source

ChemInform Abstract: Inside HDAC with HDAC Inhibitors

ChemInform, 2010
AbstractReview: 90 refs.
openaire   +1 more source

Novel HDAC Inhibitors with Radiosensitizing Properties

Radiation Research, 2005
The members of the histone deacetylase (HDAC) family play important roles in various cellular processes, including transcriptional regulation, cell proliferation, differentiation and apoptosis. Inhibitors of histone deacetylases are emerging as an important new class of chemotherapeutic agents.
Mira, Jung, Alfredo, Velena, Bin, Chen, Pavel A, Petukhov, Alan P, Kozikowski, Anatoly, Dritschilo   +5 more
openaire   +2 more sources

Epigenetic modulation and understanding of HDAC inhibitors in cancer therapy.

Life Science, 2021
M. J. Ramaiah, A. D. Tangutur, Rajasekhar Reddy Manyam   +2 more
semanticscholar   +1 more source

HDAC Inhibitors and Cancer Therapy

2010
Maintenance of normal cell growth and differentiation is highly dependent on coordinated and tight transcriptional regulation of genes. In cancer, genes encoding growth regulators are abnormally expressed. Particularly, silencing of tumor suppressor genes under the control of chromatin modifications is a major underlying cause of unregulated cellular ...
openaire   +2 more sources

Mechanisms of HDAC inhibitor-induced thrombocytopenia

European Journal of Pharmacology, 2007
Histone deacetylase inhibitors (HDAC inhibitors) are an emerging class of anticancer agents. To elucidate the mechanism of HDAC inhibitor-induced thrombocytopenia, we focused on the effects of HDAC inhibitors on megakaryocyte differentiation and performed Affymetrix GeneChip analysis of human megakaryocytic HEL cells treated with or without HDAC ...
Hideaki, Matsuoka, Akira, Unami, Takao, Fujimura, Takahisa, Noto, Yoko, Takata, Katsuhiko, Yoshizawa, Hiroaki, Mori, Ichiro, Aramori, Seitaro, Mutoh   +8 more
openaire   +2 more sources

Aspirin-inspired acetyl-donating HDACs inhibitors

Archives of Pharmacal Research, 2018
Aspirin is one of the oldest drugs for the treatment of inflammation, fever, and pain. It is reported to covalently modify COX-2 enzyme by acetylating a serine amino acid residue. By virtue of aspirin's acetylating potential, we for the first time developed novel acetyl-donating HDAC inhibitors. In this study, we report the design, synthesis, in silico
Jiah Lim, Yoojin Song, Jung-Hee Jang, Chul-Ho Jeong, Sooyeun Lee, Byoungduck Park, Young Ho Seo   +6 more
openaire   +2 more sources

HDAC Inhibitors

2006
Paul Kwon, Meier Hsu, Dalia Cohen, Peter Atadja   +3 more
openaire   +2 more sources