Results 71 to 80 of about 13,054 (213)
, 2015 Histone deacetylases (HDACs) and acetyltransferases control the epigenetic regulation of gene expression through modification of histone marks. Histone deacetylase inhibitors (HDACi) are small molecules that interfere with histone tail modification, thus
Iskar, M. +6 more
core +1 more source
HemaSphere, 2019 . The clinical use of histone deacetylase inhibitors (HDACi) for the treatment of bone marrow failure and hematopoietic malignancies has increased dramatically over the last decades.
Anita M.A.P. Govers +7 more
doaj +1 more source
Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives
MedComm – Oncology, Volume 5, Issue 2, June 2026.Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang +14 more
wiley +1 more source
Immune Evasion of Helicobacter pylori and Extra‐Gastric Cancer Risk
Journal of Gastroenterology and Hepatology, Volume 41, Issue 6, Page 1722-1742, June 2026.ABSTRACT Helicobacter pylori (H. pylori) is a group 1 gastric carcinogen that plays a significant role in extra‐gastric digestive system cancers. H. pylori disrupts host cell homeostasis through expression of virulence factors leading to immune evasion as well as persistent gastric mucosal colonization. H. pylori infection has been shown to play a role
Evren Doruk Engin +2 more
wiley +1 more source
Expression of LAT2 protein inBV2 microglia transfected with Runx1t1 siRNA or treated with HDACi.
, 2014 A–B. Western blot analysis shows that expression level of LAT2 protein (58 kDa) is significantly downregulated in microglia treated with LPS, when compared to that transfected with scrambled siRNA.
Jia Lu (181094) +4 more
core +1 more source
Effect of HDACi on KCa2.3 Expression in P0 HUVECs
, 2021 A. Immunoblot showing the effects of the HDACi TCS-A, VPA and TUB-A on freshly isolated (P0) HUVECs. Tubulin was used as a loading control. B. Quantification of immunoblot data comparing expression of KCa2.3 among control, TCS-A, TUB-A, and VPA treated ...
Claudia A. Bertuccio (309866) +8 more
core +1 more source
PharmaceuticalsHistone deacetylase inhibitors (HDACi) show high antineoplastic potential in preclinical studies in various solid tumors, including gastric carcinoma; however, their use in clinical studies has not yet yielded convincing efficacies. Thus, further studies
Leoni Lorenz +6 more
doaj +1 more source
Journal of Neurochemistry, Volume 170, Issue 6, June 2026.TDP‐43 pathology is a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Peptidyl‐prolyl cis–trans isomerase A (PPIA), a foldase and chaperone protein, modulates TDP‐43 function in an acetylation‐dependent manner. Here, we show that inhibition of lysine deacetylation with vorinostat (SAHA) increases PPIA acetylation and ...
Serena Scozzari +10 more
wiley +1 more source
Neuroendocrine tumours through an epigenetic lens: Emerging insights for diagnosis and treatment
Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.Abstract Neuroendocrine tumours (NETs) are well‐differentiated epithelial neuroendocrine neoplasms that frequently develop in the small intestine, pancreas, and lungs. NETs originate from neuroendocrine cells specialized in hormone secretion implicated in a number of physiological processes.
Victoria Jacquot +4 more
wiley +1 more source
Advanced Healthcare Materials, Volume 15, Issue 19, 22 May 2026.This study shows that stem‐like cells isolated from breast cancer brain metastases drive the spread and growth of tumors in the brain. Among them, a highly adhesive subgroup initiates metastasis and resists many drugs. By closely reflecting patient tumors, these models help identify new targets and improve the development of effective treatments ...
Stefania Faletti +27 more
wiley +1 more source