Results 91 to 100 of about 13,054 (213)

In-Cell Testing of Zinc-Dependent Histone Deacetylase Inhibitors in the Presence of Class-Selective Fluorogenic Substrates: Potential and Limitations of the Method

Biomedicines
The development of anticancer drugs based on zinc-dependent histone deacetylase inhibitors (HDACi) has acquired great practical significance over the past decade.
Alla Kleymenova, Anastasia Zemskaya, Sergey Kochetkov, Maxim Kozlov   +3 more
doaj   +1 more source

Histone deacetylase inhibitors downregulate checkpoint kinase 1 expression to induce cell death in non-small cell lung cancer cells.

PLoS ONE, 2010
BackgroundHistone deacetylase inhibitors (HDACis) are promising anticancer drugs; however, the molecular mechanisms leading to HDACi-induced cell death have not been well understood and no clear mechanism of resistance has been elucidated to explain ...
William Brazelle, Jenny M Kreahling, Jennifer Gemmer, Yihong Ma, W Douglas Cress, Eric Haura, Soner Altiok   +6 more
doaj   +1 more source

Belinostat and panobinostat (HDACI): in vitro and in vivo studies in thyroid cancer.

Journal of cancer research and clinical oncology, 2013
Advanced thyroid cancer responds poorly to most therapies. New therapies and combinations are needed. The aim of this study was to examine both in vitro and in vivo activity of two relatively new histone deacetylase inhibitors (HDACIs), belinostat and panobinostat, and a variety of tyrosine kinase inhibitors (TKIs) against a panel of nine human thyroid
Chan, D., Zheng, Y., Tyner, J.W., Chng, W.J., Chien, W.W., Gery, S., Leong, G., Braunstein, G.D., Koeffler, H.P.   +8 more
openaire   +4 more sources

Novel cell adhesion/migration pathways are predictive markers of HDAC inhibitor resistance in cutaneous T cell lymphomaResearch in context

EBioMedicine, 2019
Background: Treatment for Cutaneous T Cell Lymphoma (CTCL) is generally not curative. Therefore, selecting therapy that is effective and tolerable is critical to clinical decision-making. Histone deacetylase inhibitors (HDACi), epigenetic modifier drugs,
Jared M. Andrews, Jennifer A. Schmidt, Kenneth R. Carson, Amy C. Musiek, Neha Mehta-Shah, Jacqueline E. Payton   +5 more
doaj   +1 more source

Developmental competence of cloned porcine embryos cultured with various concentrations of HDACi-14 (JWC-022214).

, 2018
Developmental competence of cloned porcine embryos cultured with various concentrations of HDACi-14 (JWC-022214).
Jyh-Cherng Ju (430697), Chawalit Siriboon (2218384), Tzai-Shiuan Li (5798054), Chao-Wu Yu (1912129), Ji-Wang Chern (1912126)   +4 more
core   +1 more source

Developmental competence of cloned porcine embryos cultured with various concentrations of HDACi-79 (JWC-017379).

, 2018
Developmental competence of cloned porcine embryos cultured with various concentrations of HDACi-79 (JWC-017379).
Jyh-Cherng Ju (430697), Chawalit Siriboon (2218384), Tzai-Shiuan Li (5798054), Chao-Wu Yu (1912129), Ji-Wang Chern (1912126)   +4 more
core   +1 more source

Histone Deacetylases and their Inhibitors in Cancer Epigenetics

Diseases, 2019
Histone deacetylases (HDAC) and histone deacetylase inhibitors (HDACi) have greatly impacted the war on cancer. Their role in epigenetics has significantly altered the development of anticancer drugs used to treat the most rare, persistent forms of ...
Kelly N. Hassell
doaj   +1 more source

Effects of Alcohol and/or HDACi on Oxidative Stress and Antioxidant Defense Genes.

, 2016
Effects of Alcohol and/or HDACi on Oxidative Stress and Antioxidant Defense Genes.
Venkata Atluri (2818501), Karla Muñoz (2818498), Marisela Agudelo (504249), Thangavel Samikkannu (471645), Tiyash Parira (2818495), Adriana Yndart (404585), Madhavan P. Nair (2818504), Gloria Figueroa (2818507)   +7 more
core   +1 more source

Design, Synthesis, and Characterization of HDACi Derivatives with Special Stereochemistry

In designing new therapeutic candidates, it is crucial to consider stereochemistry, as diastereomers and enantiomers of chiral drugs could present distinct affinities toward various biomolecules including the targeted ones, which, in turn, affects a drug’
Pang, Juhyeong, Artero, Karina, Sanchez, Brenda, Zhao, Qinliang   +3 more
core   +1 more source

Class I HDAC inhibitors enhance antitumor efficacy and persistence of CAR-T cells by activation of the Wnt pathway

Cell Reports
Summary: Epigenetic modification shapes differentiation trajectory and regulates the exhaustion state of chimeric antigen receptor T (CAR-T) cells. Limited efficacy induced by terminal exhaustion closely ties with intrinsic transcriptional regulation ...
Meng Zhu, Yingli Han, Tianning Gu, Rui Wang, Xiaohui Si, Delin Kong, Peng Zhao, Xiujian Wang, Jinxin Li, Xingyuan Zhai, Zebin Yu, Huan Lu, Jingyi Li, He Huang, Pengxu Qian   +14 more
doaj   +1 more source