Results 111 to 120 of about 13,054 (213)
, 2015 The MDM2-p53 pathway plays a prominent role in well-differentiated liposarcoma (LPS) pathogenesis. Here, we explore the importance of MDM2 amplification and p53 mutation in LPS independently, to determine whether HDACi are therapeutically useful in LPS ...
Liu, Li +12 more
core
Proteins Involved in HDACi Induced Decay of ERBB2 Transcripts in Breast Cancer
, 2015 ERBB2-positive breast cancer is an aggressive disease form that can result in rapid tumor growth and metastasis driven by the overexpression of ERBB2 growth factor receptors present on the cell surface.
Malik, Sadaf
core +1 more source
HDACiDB: a database for histone deacetylase inhibitors
Drug Design, Development and Therapy, 2015 Kasi Murugan,1 Shanmugasamy Sangeetha,2 Shanmugasamy Ranjitha,2 Antony Vimala,2 Saleh Al-Sohaibani,1 Gopal Rameshkumar21Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia; 2Bioinformatics Laboratory ...
Murugan K +5 more
doaj
HDACi exposure in DHA-treated cells enhanced decreases of Mcl-1 and p-ERK. A.
, 2013 Combination treatment with HDACi and DHA resulted in downregulation of Mcl-1 and upregulation of Bak. liver cancer cells were exposed to 4 mM NaB, 1.25 μM SAHA, 10 μM DHA or combination of NaB/SAHA and DHA for 24 h.
Paul B. S. Lai (317945) +6 more
core +1 more source
, 2023 Cancer, an illness causing uncontrollable cell division, has devastating effects on the lives of many, leading to extensive research in this field. It has been proven that platinum-based drugs are able to treat cancer in some form, but studies show that ...
Gill, Arjan +4 more
core
, 2011 The anti-tumor activity of histone deacetylase inhibitors (HDACI) on multi-drug resistant sarcoma cell lines has never been previously described.
Schwab, Joseph H +7 more
core
, 2019 The adenoviral early region 1A (E1A) protein has proapoptotic and angiogenic activity, along with its chemosensitizing effect, making it the focus of increased interest in the context of cancer therapy.
Alisa Morshneva +3 more
core +1 more source
, 2013 Histone deacetylase inhibitors (HDACi) are anti-cancer drugs that primarily act upon acetylation of histones, however they also increase levels of intracellular reactive oxygen species (ROS).
Rivera-Del Valle, Nilsa
core
HDACi drugs hamper experimental mouse teratoma development
, 2020 Testicular Germ Cell Tumours (TGCT) are the most frequent malignancies in young males, driven by epimutations. Teratoma are TGCT composed of all three germ layer tissues. Mouse teratoma model, due to its heterogeneity and pluripotent core, is a very reliable in vitro model for investigating the effect of cancer drugs, including histone deacetylase ...
Krasić, Jure +6 more
openaire +1 more source
Hypophosphatemia as a Potential Class Effect of Histone Deacetylase Inhibitors: Evidence from Disproportionality Analysis and Mendelian Randomization Analysis of Drug Targets. [PDF]
Pharmaceuticals (Basel)Zhao R +5 more
europepmc +1 more source