Results 101 to 110 of about 13,054 (213)

Decreased DHRS2 expression is associated with HDACi resistance and poor prognosis in ovarian cancer

, 2019
Histone deacetylases (HDACs) have been linked to a variety of cancers, and HDAC inhibitors (HDACi) are a promising class of drugs that have demonstrated anti-cancer effects.
Zeyu Zhang (549929), Yingyan Han (534806), Shujuan Sun (498986), Peng Wu (210686), Jia Liu (41593), Xin Jin (108988), Zhi Wang (193655), Wencheng Ding (498984), Beibei Wang (105269), Qinglei Gao (549924), Teng Ji (498985)   +10 more
core   +1 more source

Lactylation of HDAC1 Confers Resistance to Ferroptosis in Colorectal Cancer

Advanced Science
Colorectal cancer (CRC) is highly resistant to ferroptosis, which hinders the application of anti‐ferroptosis therapy. Through drug screening, it is found that histone deacetylase inhibitor (HDACi) significantly sensitized CRC to ferroptosis.
Zhou Yang, Wei Su, Qinglin Zhang, Lili Niu, Baijie Feng, Yu Zhang, Feng Huang, Jiaxin He, Qinyao Zhou, Xin Zhou, Longjun Ma, Jingwan Zhou, Yuanrong Wang, Wenjing Xiong, Jun Xiang, Zhilin Hu, Qiang Zhan, Bing Yao   +17 more
doaj   +1 more source

Ex vivo response of patient-derived HIV LTRs to HDACi in A. SVG and B. HeLa cell lines.

, 2014
(I) Each cell line was incubated with different concentrations of HDACi for 24 hr and toxicity was measured by the MTS assay. The cytotoxic concentration 50 (CC50) for each drug is shown.
Paul U. Cameron (210950), Gabriela Khoury (663684), Wan-Jung Cheng (220322), Melissa J. Churchill (217157), Steve Wesselingh (243339), Paula Ellenberg (663683), Talia M. Mota (663685), Lachlan R. Gray (403046), Fiona Wightman (659651), Paul R. Gorry (217168), Hao K. Lu (327717), Sharon R. Lewin (130160)   +11 more
core   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Extrachromosomal HPV-16 LCR transcriptional activation by HDACi opposed by cellular differentiation and DNA integration

, 2016
Histone deacetylase inhibitors (HDACi) have been shown to render HPV-carrying cells susceptible to intrinsic and extrinsic apoptotic signals. As such, these epigenetic drugs have entered clinical trials in the effort to treat cervical cancer.
Fontaine, Véronique, Bojilova Dimitrova, Ekaterina, Antoine, Marie-Hélène, Weyn, Christine   +3 more
core   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

ARHGEF3 controls HDACi-induced differentiation via RhoA-dependent pathways in acute myeloid leukemias.

, 2015
Altered expression and activity of histone deacetylases (HDACs) have been correlated with tumorigenesis. Inhibitors of HDACs (HDACi) induce acetylation of histone and non-histone proteins affecting gene expression, cell cycle progression, cell migration,
Dell'Aversana C, D'Amato L, NEBBIOSO, Angela, Ciotta A, SCISCIOLA, Lucia, ALTUCCI, Lucia, Conte M, Carissimo A   +7 more
core   +2 more sources

ISEV2026 Abstract Book

Journal of Extracellular Vesicles, Volume 15, Issue S1, June 2026.
wiley   +1 more source

HDACi decrease NK function.

, 2016
A) NK cells treated with or without HDACi (as PBMC) for 24h (effectors) were co-cultured or not with HIV-1 LAI-infected 100nM panobinostat treated CD4 T cells (targets) and uninfected CD4 T cells (non-targets) overnight at an E:T:NT ratio of 10:1:1 (n ...
Matthew Pace (2954127), Julie Fox (322026), Ayako Kurioka (2954130), Andrew B. Gerry (2954133), Sarah Fidler (76851), Bent Jakobsen (2954136), John Frater (236996), James Williams (806280), Nneka Nwokolo (2879681), Paul Klenerman (33807)   +9 more
core   +1 more source

HDACi Valproic Acid (VPA) and Suberoylanilide Hydroxamic Acid (SAHA) Delay but Fail to Protect against Warm Hepatic Ischemia-Reperfusion Injury.

, 2016
Histone deacetylases (HDAC) catalyze N-terminal deacetylation of lysine-residues on histones and multiple nuclear and cytoplasmic proteins. In various animal models, such as trauma/hemorrhagic shock, ischemic stroke or myocardial infarction, HDAC ...
Wittel, Uwe A., Rueß, Dietrich A., Goran Marjanovic (2938566), Moriz Probst, Keck, Tobias, Dietrich A. Ruess (2938557), Uwe A. Wittel (340768), Probst, Moriz, Uwe A Wittel, Dirk Bausch, Dirk Bausch (2938554), Hopt, Ulrich T., Goran Marjanovic, Tobias Keck (2938560), Dietrich A Ruess, Ulrich T Hopt, Ulrich T. Hopt (731427), Marjanovic, Goran, Tobias Keck, Moriz Probst (2938563)   +19 more
core   +1 more source