Results 151 to 160 of about 685,850 (392)

Exonic Variation and Its Clinical Impact in 7221 Old Order Amish

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The Amish of Lancaster County, PA has been the focus of genetic studies for many years due to its demographic history and unique genetic makeup that includes a historical bottleneck event and subsequent genetic drift, resulting in a marked decrease in genetic diversity and increased frequency of some variants that have substantially shaped the
Braxton D. Mitchell, Ebuka Onyenobi, Joshua P. Lewis, Brady Gaynor, James A. Perry, Kristin Maloney, Jeffrey R. O'Connell, Jessica Tiner, Amber L. Beitelshees, Cristopher V. Van Hout, Patrick F. McArdle, Huichun Xu, Erik G. Puffenberger, Karlla W. Brigatti, Melanie Daue, Hilary B. Whitlatch, Anna Alkelai, Alejandro A. Schäffer, John Overton, Elizabeth A. Streeten, Toni I. Pollin, Alan R. Shuldiner   +21 more
wiley   +1 more source

The Role of SLC39A8.p.(Ala391Thr) in Schizophrenia Symptom Severity and Cognitive Ability: Cross‐Sectional Studies of Schizophrenia and the General UK Population

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT The missense SNP NC_000004.12:g.102267552C>T (also known as SLC39A8.p.(Ala391Thr), rs13107325) in SLC39A8 encodes a zinc transporter. This SNP has been linked to schizophrenia and is the likely causal variant for one of the genome‐wide association loci associated with the disorder. Using regression analyses, we tested whether the schizophrenia‐
Sophie E. Smart, Sophie E. Legge, Eilidh Fenner, Antonio F. Pardiñas, Grace Woolway, Amy J. Lynham, Valentina Escott‐Price, Jeremy Hall, Lawrence Wilkinson, Peter Holmans, Michael C. O'Donovan, Michael J. Owen, James T.R. Walters   +12 more
wiley   +1 more source

Adverse Cardiovascular Risk Profile and Increased Diurnal Salivary Cortisol in Girls With Turner Syndrome: An Exploratory Study

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Patients with Turner Syndrome (TS) and those exposed to high concentrations of glucocorticoids have a number of characteristics in common, including an increased risk of cardiovascular disease. Pediatric TS patients underwent studies of salivary cortisol (SC) and cortisone (SCn), body composition, continuous glucose monitoring, vascular ...
Lily Jones, Julie Park, Silothabo Dliso, Daniel B. Hawcutt, Alena Shantsila, Gregory Y. H. Lip, Joanne Blair   +6 more
wiley   +1 more source

Study of pro-oxidant status in acute myocardial infarction

Asian Journal of Medical Sciences, 2018
Background: Apart from several well documented risk factors; oxidative stress may play an important role in the pathogenesis of myocardial infarction. Our study has been designed to investigate the pro-oxidant status in AMI patients who have no previous ...
Tanushri Khatua , Chandan Sarkar , Sujit Kumar Dey, Biswajit Majumder   +3 more
doaj   +1 more source

Differences in GlycA and lipoprotein particle parameters may help distinguish acute kawasaki disease from other febrile illnesses in children. [PDF]

, 2016
BackgroundGlycosylation patterns of serum proteins, such as α1-acid glycoprotein, are modified during an acute phase reaction. The response of acute Kawasaki disease (KD) patients to IVIG treatment has been linked to sialic acid levels on native IgG ...
Burns, Jane C, Connelly, Margery A, Kanegaye, John T, Otvos, James D, Pourfarzib, Ray, Shalaurova, Irina, Shimizu, Chisato, Tremoulet, Adriana H, Winegar, Deborah A   +8 more
core   +3 more sources

A hepatoprotective experiment on taro vegetable (Colocasia esculenta (L.) Schott) flower employing animal models by mitigating oxidative stress

Animal Models and Experimental Medicine, EarlyView.
The antioxidant efficacy of Colocasia esculenta flower’s methanolic extract was assessed using 2,2′‐azino‐bis‐(3‐ethylbenzothiazoline‐6‐sulfonic) (ABTS) and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) scavenging assay. The hepatoprotective effect was investigated by assessing liver injury indicators (amino transferase [ALT], aspartate amino transferase [AST],
Mahathir Mohammad, Fahmida Tasnim Richi, Rabiul Hossain, Md. Arafat, Pair Ahmed Jiko, Nazim Uddin Emon, Sayed Al Hossain Rabbi, Tirtha Khastagir, Md. Hemayet Hossain, Safaet Alam   +9 more
wiley   +1 more source

Protective effects of allicin against stanozolol‐induced cardiotoxicity: Physiological and histopathological evidence in a rabbit model

Animal Models and Experimental Medicine, EarlyView.
There are many forms of anabolic steroids, including stanzolo (Winstrol), which are popular for their muscle‐building effects but dangerous to the heart. This present work is aimed at evaluating the pharmacological impact of allacin, a natural attribute obtained from garlic on obstructing cardiac injury in rabbits that received stanzolo.
Mohammed Hayder Asker, Noor AL‐Huda Salah AL‐Zuhairy, Wassan Mhammed Husain, Mustafa Riyadh Abdullah   +3 more
wiley   +1 more source

Research progress on traditional Chinese medicine animal models of post‐stroke depression and pathological insights

Animal Models and Experimental Medicine, EarlyView.
Post‐stroke depression (PSD) animal model of traditional Chinese medicine (TCM) combined with disease and syndrome often uses western medicine surgery (including: middle cerebral artery embolization to construct cerebral ischemia, or brain injection of collagenase to construct cerebral hemorrhage) combined with other methods (including: isolation ...
Jielin Wang, Wenlu Ma, Wei Wu, Yujuan Fu, Hui Li   +4 more
wiley   +1 more source

Midlife Steroid‐Binding Globulin Levels and In Vivo Neuroimaging Measures of Tau in Older Men and Women

Annals of Neurology, EarlyView.
Objective In men and women, sex steroid hormones have been associated with increased risk of Alzheimer's disease (AD) dementia. We aimed to investigate the influence of midlife testosterone and sex hormone binding globulin (SHBG) levels on later‐life in vivo markers of β‐amyloid (Aβ) and tau deposition in clinically healthy older men. Methods This time‐
Rachel F. Buckley, Matthew Scott, Emer R. McGrath, Gillian Coughlan, Mabel Seto, Saptaparni Ghosh, Heidi I. L. Jacobs, Claudia L. Satizabal, Emma Thibault, Vasan Ramachandran, Joanne M. Murabito, Reisa A. Sperling, Keith A. Johnson, Ravi Jasuja, Shalender Bhasin, Sudha Seshadri, Alexa S. Beiser   +16 more
wiley   +1 more source

Structured Lipids: Synthesis, Genetic Engineering, and Applications

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Lipids are essential to the human body, but some can be harmful. As a result, current research focuses on structured lipids (SLs), which are engineered to have specific fatty acid arrangements. These structural modifications can enhance both nutritional and physical properties.
Chandu S. Madankar, Avishkar S. Bhagat, Elham K. Nasser, Ammar B. Altemimi, Francesco Cacciola, Nasser Mahna   +5 more
wiley   +1 more source