Results 11 to 20 of about 198,685 (310)

Tipifarnib in Head and Neck Squamous Cell Carcinoma With HRAS Mutations

Journal of Clinical Oncology, 2021
PURPOSE Mutations in the HRAS (mHRAS) proto-oncogene occur in 4%-8% of patients with recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). Tipifarnib is a farnesyltransferase inhibitor that disrupts HRAS function.
A. Ho, I. Braña, R. Haddad, J. Bauman, K. Bible, S. Oosting, D. Wong, M. Ahn, V. Boni, C. Even, J. Fayette, M. J. Flor, K. Harrington, Sung-Bae Kim, L. Licitra, I. Nixon, N. Saba, Stephan Hackenberg, P. Specenier, F. Worden, B. Balsara, M. Leoni, B. Martell, C. Scholz, A. Gualberto   +24 more
semanticscholar   +1 more source

Tumor microenvironment and immune evasion in head and neck squamous cell carcinoma

International Journal of Oral Science, 2021
Head and neck squamous cell carcinoma (HNSCC), an aggressive malignancy, is characterized by high morbidity and low survival rates with limited therapeutic options outside of regional surgery, conventional cytotoxic chemotherapy, and irradiation ...
Areeg Elmusrati, Justin Wang, Cun-Yu Wang   +2 more
semanticscholar   +1 more source

Is a Preoperative Gastrointestinal Endoscopy for Second Primary Cancer Detection in Head and Neck Cancer Necessary? Ten-year Registry Data

The Korean Journal of Gastroenterology, 2016
Background : /Aims: In head and neck squamous cell carcinoma, second primary gastrointestinal tumors are not uncommon. However, it is unclear whether a screening endoscopy is needed for detecting gastrointestinal neoplasm in patients with head and neck ...
Gyeong Mi Heo, Mi Hee Kim, Jin Hwan Kim, Young Soo Rho, Woon Geon Shin   +4 more
doaj   +1 more source

Human Papilloma Virus (HPV) Induced Head & Neck Squamous Cell Carcinoma: A Comprehensive Retrospect [PDF]

Journal of Clinical and Diagnostic Research, 2015
Head and Neck Squamous Cell Carcinoma accounts for the sixth most common malignancy occurring worldwide with tobacco and alcohol being the two well established risk factors.
Roquaiya Nishat, Shyam Sundar Behura, Sujatha Ramachandra, Harish Kumar, Alokenath Bandyopadhyay   +4 more
doaj   +1 more source

Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy

Signal Transduction and Targeted Therapy, 2021
Head and neck squamous cell carcinoma (HNSCC) is a very aggressive disease with a poor prognosis for advanced-stage tumors. Recent clinical, genomic, and cellular studies have revealed the highly heterogeneous and immunosuppressive nature of HNSCC ...
A. Bhat, Parvaiz Yousuf, N. Wani, Arshi Rizwan, S. Chauhan, M. Siddiqi, D. Bedognetti, W. El-Rifai, M. Frenneaux, S. Batra, Mohammad Haris, M. Macha   +11 more
semanticscholar   +1 more source

¹⁸F-fluorodeoxyglucose positron emission tomography combined with computed tomography in squamous cell carcinoma of the head and neck (literature review)

Опухоли головы и шеи, 2019
Most of the malignant neoplasms of the head and neck are represented by squamous cell carcinoma. 18F-fluorodeoxyglucose positron emission tomography combined with computed tomography in squamous cell carcinoma of the head and neck is applied for primary ...
О. D. Ryzhova, М. B. Dolgushin, A. I. Mikhaylov, Е. L. Dronova, D. I. Nevzorov, А. М. Mudunov, S. B. Alieva   +6 more
doaj   +1 more source

Head and neck squamous cell carcinoma

, 2011
Review on Head and neck squamous cell carcinoma, with data on clinics, and the genes involved.
H. Blons
semanticscholar   +1 more source

Clinical Controversy Surrounding the Differential Diagnosis of Branchiogenic Carcinoma

Case Reports in Otolaryngology, 2022
Clinical evaluation, differential diagnosis, and management of a neck mass constitute commonly encountered problems for the head and neck surgeon. An asymptomatic neck mass in adults may be the only clinical sign of head and neck cancer.
Alexander Karatzanis, Kleanthi Mylopotamitaki, Eleni Lagoudaki, Emmanuel Prokopakis, Sofia Agelaki   +4 more
doaj   +1 more source

Evaluation of epigenetic inactivation of vascular endothelial growth factor receptors in head and neck squamous cell carcinoma

Tumor Biology, 2017
The aim of this study was to determine the methylation status of the genes encoding the vascular endothelial growth factor receptors and to evaluate the usefulness of VEGFR methylation as a prognostic indicator in head and neck squamous cell carcinoma ...
Yuki Misawa, Kiyoshi Misawa, Hideya Kawasaki, Atsushi Imai, Daiki Mochizuki, Ryuji Ishikawa, Shiori Endo, Masato Mima, Takeharu Kanazawa, Toshihide Iwashita, Hiroyuki Mineta   +10 more
doaj   +1 more source

Circulating tumor cells in head and neck cancer: A review

World Journal of Otorhinolaryngology-Head and Neck Surgery, 2016
Carcinoma of the head and neck represents 3.5% of all cancers, and the vast majority of these tumors are squamous cell carcinoma (HNSCC). With a stable overall survival rate of 50% among all stages, there is continued interested in developing measures ...
Kyle P. McMullen, Jeffrey J. Chalmers, Jas C. Lang, Pawan Kumar, Kris R. Jatana   +4 more
doaj   +1 more source