Results 41 to 50 of about 152,721 (288)

Cetuximab in squamous cell head and neck carcinomas

Annals of Oncology, 2007
The epidermal growth factor receptor (EGFR) antagonist, cetuximab, has recently been shown to enhance the effects of radiotherapy, and reports to date indicate that this effect occurs without any change in the pattern and severity of toxicity usually associated with head and neck radiation and/or chemotherapy (CT) administration.
GEBBIA, Vittorio, GIULIANI G, VALORI VM, AGUELI R, COLUCCI G, MAIELLO E.   +5 more
openaire   +3 more sources

Expression of CXCL10 is associated with response to radiotherapy and overall survival in squamous cell carcinoma of the tongue [PDF]

, 2014
Five-year survival for patients with oral cancer has been disappointingly stable during the last decades, creating a demand for new biomarkers and treatment targets.
Philip John Coates, Torben Wilms, Laurell, Göran,, Rentoft, Matilda,, Coates, Philip John, Matilda Rentoft, Lotta Loljung, Göran Laurell, Karin Nylander, Rentoft, Matilda, Laurell, Göran, Wilms, Torben, Loljung, Lotta, Nylander, Karin, Loljung, Lotta,, Wilms, Torben,, Nylander, Karin,, Coates, Philip John,   +17 more
core   +1 more source

and variations in outcomes of tobacco- and alcohol-related head and neck squamous cell carcinoma patients

Tumor Biology, 2020
Radiotherapy and cisplatin lead to cell killing in head and neck squamous cell carcinoma patients, but adverse events and response to treatment are not the same in patients with similar clinicopathological aspects.
Ericka Francislaine Dias Costa, Tathiane Regine Penna Lima, Leisa Lopes-Aguiar, Guilherme Augusto Silva Nogueira, Marília Berlofa Visacri, Julia Coelho França Quintanilha, Eder Carvalho Pincinato, Luciane Calonga, Fernanda Viviane Mariano, Albina Messias de Almeida Milani Altemani, João Maurício Carrasco Altemani, Patrícia Moriel, Carlos Takahiro Chone, Celso Dario Ramos, Carmen Silvia Passos Lima   +14 more
doaj   +1 more source

Invasive head and neck cutaneous squamous cell carcinoma: clinical and histopathological characteristics, frequency of local recurrence and metastasis [PDF]

Anais Brasileiros de Dermatologia, 2014
BACKGROUND: squamous cell carcinoma is the second most common type of skin malignancy and may evolve to regional lymph node and distant metastases. OBJECTIVE: The objective of this study was to evaluate patients with head and neck cutaneous squamous ...
Luiza Vasconcelos, Juliana Carneiro Melo, Hélio Amante Miot, Mariângela Esther Alencar Marques, Luciana Patricia Fernandes Abbade   +4 more
doaj   +1 more source

Basaloid Squamous Cell Carcinoma of the Head and Neck [PDF]

The Laryngoscope, 2000
AbstractObjective/Hypothesis Basaloid squamous cell carcinoma (BSCC), an uncommon tumor with predilection for the upper aerodigestive tract, is a distinct variant of squamous carcinoma, because of its unique histological features and ominous clinical behavior.
A F, Paulino, B, Singh, J P, Shah, A G, Huvos   +3 more
openaire   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Molecular Characterization of ‘p53 Family Network’ in Human Head and Neck Cancer and Anti-EGFR Therapy [PDF]

, 2008
Understanding of p53 family protein (p53, p63 and p73) networks in head and neck squamous cell carcinoma (HNSCC), can positively influence in cancer screening, diagnosis, treatment and prevention.
Sebastian, Sinto
core   +1 more source

The role of FOXM1 in oral squamous cell carcinoma [PDF]

, 2010
PhDFOXM1 transcription factor regulates the expression of a multitude of genes, which are important for cell proliferation, mitosis, and differentiation.
Gemenetzidis, Emilios
core   +4 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source