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Immunotherapy for Head and Neck Squamous Cell Carcinoma [PDF]
Current Oncology Reports, 2018 Discussion of current strategies targeting the immune system related to solid tumors with emphasis on head and neck squamous cell carcinoma (HNSCC).This review will outline the current challenges with immunotherapy and future goals for treatment using these agents.Agents targeting immune checkpoint receptors (IR) such as program death 1 (PD1) have been
Moskovitz, Jessica +2 more
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Fibroblasts in head neck squamous cell carcinoma associated with perineural invasion have high level nuclear Yes-Associated Protein (YAP) expression [PDF]
, 2015 Paul A. Reynolds, PhD, is supported by the Melville Trust for the Care and cure of Cancer.We retrospectively studied the expression of Yes-associated protein (YAP) using immunohistochemical staining in 10 cases of head and neck squamous cell carcinoma ...
Gersten, Adam +5 more
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PKM2 Modulation in Head and Neck Squamous Cell Carcinoma [PDF]
International Journal of Molecular Sciences, 2022 The enzyme pyruvate kinase M2 (PKM2) plays a major role in the switch of tumor cells from oxidative phosphorylation to aerobic glycolysis, one of the hallmarks of cancer. Different allosteric inhibitors or activators and several posttranslational modifications regulate its activity. Head and neck squamous cell carcinoma (HNSCC) is a common disease with
Verena Boschert +4 more
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CD44s and CD44v6 Expression in Head and Neck Epithelia [PDF]
, 2008 Background: CD44 splice variants are long-known as being associated with cell transformation. Recently, the standard form of CD44 (CD44s) was shown to be part of the signature of cancer stem cells (CSCs) in colon, breast, and in head and neck squamous ...
Olivier Gires +7 more
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Exosomes in Head and Neck Squamous Cell Carcinoma [PDF]
Frontiers in Oncology, 2019 Exosomes are small membranous vesicles that contain proteins, lipids, genetic material, and metabolites with abundant information from parental cells. Exosomes carry and deliver bioactive contents that can reprogram the functions of recipient cells and modulate the tumor microenvironment to induce pathological events through cell-to-cell communication ...
Cheng Xiao +5 more
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Gefitinib and Radiotherapy in patients with locally advanced inoperable squamous cell carcinoma of the head and neck [PDF]
, 2008 Introduction: Gefitinib, an orally active epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, induces growth arrest in squamous cancer cell carcinoma of head and neck (SCCHN) cell lines mainly by blocking cells in G1 and preventing them ...
Romano, Carmela
core +1 more source
Gene expression profiling of head and neck cancer [PDF]
, 2004 MDThe purpose of this study was to classify oral squamous cell carcinomas (OSCCs) based on their gene expression profiles, to identify differentially expressed genes in these cancers, and to correlate genetic deregulation with clinical ...
Warner, Giles C
core +4 more sources
Tumor Biology, 2017 The aim of this study was to determine the methylation status of the genes encoding the vascular endothelial growth factor receptors and to evaluate the usefulness of VEGFR methylation as a prognostic indicator in head and neck squamous cell carcinoma ...
Yuki Misawa +10 more
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Hypoxia in Head and Neck Squamous Cell Carcinoma [PDF]
ISRN Otolaryngology, 2012 Hypoxia is a common feature in most of the solid tumors including head and neck squamous cell carcinoma (HNSCC). Hypoxia reflects the imbalance between oxygen consumption by the rapidly proliferating cancer cells and the insufficient oxygen delivery due to poor vascularization and blood supply.
John Zenghong Li +4 more
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Tumor Biology, 2017 Oropharyngeal head and neck squamous cell carcinoma is a common malignant tumor in the oral cavity. High-risk human papillomavirus 16 infection is a major cause of oropharyngeal head and neck squamous cell carcinoma development.
Jianfeng Dong +5 more
doaj +1 more source