Results 91 to 100 of about 107,517 (316)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Ageing and Mobility- Making the Connections [PDF]
, 2010 Spatial mobility in later life has received much attention by researchers and policy makers in recent years as part of discourses around active ageing and ageing independently.
Ziegler, Rahel Friederike +1 more
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The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
International Journal of Population Data ScienceObjectives In Australia, there are no standardised processes for the release of Electronic Health Record (EHR) data for research. We describe our streamlined ethics and data access governance framework for the release of EHR data for research ...
Emily Parker +6 more
doaj +1 more source
, 2014 Background. In an ageing society cognitive decline is expected to become an important health problem. Previous studies showed that a healthy lifestyle, i.e. sufficient physical activity and a healthy diet,can benefit cognitive function. In this study, we
Visser, M. +3 more
core
Aged care in Australia: part I – policy, demand and funding [PDF]
, 2014 As population ageing means more people will require care and support, this research brief looks at demand and funding of formal and informal care.
core
Visual perception and visual cognition in healthy and pathological ageing [PDF]
, 2014 Our understanding of visual perception and visual cognition has advanced considerably over the last decades. The effects of ageing on visual perception and visual cognition are less well understood.
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Clinical Interventions in AgingTheng Choon Ooi,1,2 Nurul Fatin Malek Rivan,1 Suzana Shahar,1 Azianah Mohamad Ibrahim,1 Devinder Kaur Ajit Singh1 1Centre for Healthy Ageing and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala ...
Ooi TC +4 more
doaj