Results 111 to 120 of about 91,653 (266)

Author Correction: Neuroimaging and cognitive correlates of retinal Optical Coherence Tomography (OCT) measures at late middle age in a twin sample

Scientific Reports, 2022
Chris Moran, Zheng Yang Xu, Hemal Mehta, Mark Gillies, Chris Karayiannis, Richard Beare, Christine Chen, Velandai Srikanth   +7 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Multidomain Healthy-Age Programme. Recomendations for Healthy Ageing: On Behalf of the Healthy-Age Network

, 2021
El envejecimiento es un proceso natural asociado a un declive que repercute en un mayor riesgo de padecer discapacidad física y cognitiva, y/o afección emocional y social. En consecuencia, diversos estudios muestran los múltiples beneficios de los programas de entrenamiento multicomponente.
Marcos Pardo, Pablo Jorge, González Gálvez, Noelia, Vaquero Cristóbal, Raquel, Sagarra Romero, Lucía, López Vivancos, Abraham, Velázquez Díaz, Daniel, Gea García, Gemma María, Ponce González, Jesús Gustavo, Esteban Cornejo, Irene, Jiménez Pavón, David, Carbonell Baeza, Ana   +10 more
openaire   +1 more source

Disability free life expectancy: a simulation study of scenarios to extend healthy years and reduce inequalities

BMC Medicine
Background The gap in Disability-Free Life Expectancy between affluent and deprived areas of England is stark, at over 15 years. Successive governments have recognised the need to narrow this and extend the years of life spent without disability, but ...
David R Sinclair, Laurie E Davies, Barbara Hanratty, Chris Todd, Fiona E Matthews, Andrew Kingston   +5 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Healthy ageing begins with a healthy lifestyle

eBioMedicine, 2023
openaire   +2 more sources

The impact of frailty on the use of social services, medication and mortality risk: a cross-sectional study

BMC Geriatrics
Background Frailty is a common condition in older people, and its prevalence increases with age. With an ageing population, the adverse consequences of frailty cause an increasing appeal to the health care system.
Nanda Kleinenberg-Talsma, Fons van der Lucht, Harriët Jager-Wittenaar, Wim Krijnen, Evelyn Finnema   +4 more
doaj   +1 more source