Results 131 to 140 of about 107,517 (316)

Healthy human ageing

New Biotechnology, 2008
Udgivelsesdato ...
openaire   +2 more sources

Embodying 'active' ageing: bodies, emotions and risk in later life [PDF]

The promotion of 'active' ageing in later life has been a key development in recent health policy. These changes not only challenge the prevalent view of old age as an inevitable process of biological decline but signify the tendency of lay and expert ...
Martin, Wendy
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Incident disability in older adults: prediction models based on two British prospective cohort studies

, 2014
Objective: to develop and validate a prediction model for incident locomotor disability after 7 years in older adults.Setting: prospective British cohort studies: British Women's Heart and Health Study (BWHHS) for development and the English Longitudinal
Bowling, A., Kumari, Meena, Prieto-Merino, David, Dale, C.E., Kumari, M., Casas, Juan P, Bowling, Ann, Prieto-Merino, D., Pablo, Perel, Nüesch, Eveline, Dale, Caroline E, Pablo, P., Casas, J.P., Ebrahim, S., Ebrahim, Shah, Nuesch, E.   +15 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Synergistic effects of cognitive frailty and comorbidities on disability: a community-based longitudinal study

BMC Geriatrics
Objective In this study, we aimed to assess the synergistic effects of cognitive frailty (CF) and comorbidity on disability among older adults. Methods Out of the 1318 participants from the Malaysian Towards Useful Aging (TUA) study, only 400 were ...
Nurul Fatin Malek Rivan, Resshaya Roobini Murukesu, Suzana Shahar, Nor Fadilah Rajab, Ponnusamy Subramaniam, Theng Choon Ooi, Mohd Zul Amin Kamaruddin, Devinder Kaur Ajit Singh   +7 more
doaj   +1 more source

How do people with learning disabilities experience and make sense of the ageing process? [PDF]

, 2013
Not enough is currently known about how people with learning disabilities experience and understand the ageing process. This is particularly important as the population of older people with learning disabilities is growing due to increased life ...
Newberry, Gayle
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The impact of frailty on the use of social services, medication and mortality risk: a cross-sectional study

BMC Geriatrics
Background Frailty is a common condition in older people, and its prevalence increases with age. With an ageing population, the adverse consequences of frailty cause an increasing appeal to the health care system.
Nanda Kleinenberg-Talsma, Fons van der Lucht, Harriët Jager-Wittenaar, Wim Krijnen, Evelyn Finnema   +4 more
doaj   +1 more source