Results 121 to 130 of about 107,517 (316)

Vaccination and healthy aging

Expert Review of Vaccines, 2010
The aging process in humans is associated with a decrease in immune function (immunosenescence) and an increase in comorbid disorders. When combined with environmental factors this can lead to an increased risk and severity of infectious diseases. Diseases in older adults (>/=70 years) tend to be more severe and have a greater impact on health outcomes
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Colony level fitness analysis identifies a trade-off between population growth rate and dauer yield in Caenorhabditis elegans

BMC Ecology and Evolution
Background In the evolution from unicellular to multicellular life forms, natural selection favored reduced cell proliferation and even programmed cell death if this increased organismal fitness.
Hannah Chapman, Kuei Ching Hsiung, Isadora Rawlinson, Evgeniy R. Galimov, David Gems   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

DamID in C. elegans reveals longevity‐associated targets of DAF‐16/FoxO

Molecular Systems Biology, 2010
Insulin/IGF‐1 signaling controls metabolism, stress resistance and aging in Caenorhabditis elegans by regulating the activity of the DAF‐16/FoxO transcription factor (TF).
Eugene Schuster, Joshua J McElwee, Jennifer M A Tullet, Ryan Doonan, Filip Matthijssens, John S Reece‐Hoyes, Ian A Hope, Jacques R Vanfleteren, Janet M Thornton, David Gems   +9 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Author Correction: Neuroimaging and cognitive correlates of retinal Optical Coherence Tomography (OCT) measures at late middle age in a twin sample

Scientific Reports, 2022
Chris Moran, Zheng Yang Xu, Hemal Mehta, Mark Gillies, Chris Karayiannis, Richard Beare, Christine Chen, Velandai Srikanth   +7 more
doaj   +1 more source

Profiling plasma peptides for the identification of potential ageing biomarkers in Chinese Han adults

, 2012
Advancing age is associated with cardiovascular disease, diabetes mellitus and cancer, and shows significant inter-individual variability. To identify ageing-related biomarkers we performed a proteomic analysis on 1890 Chinese Han individuals, 1136 males
Manshu Song (153063), Xinwei Yu (153054), Feifei Zhao, Li, Y., Manshu Song, Jingjing Wu (153040), Alan H Bittles, Jiapeng Lu (153024), Zhang, Y., Jiapeng Lu, Wei Wang, Wang, Youxin, Yu, Xinwei, Meng, S., Wu, Jingjing, Song, Manshu, Huang, Y., Qingwei Ma (153058), Chang, Naibai, Shijiao Meng, Meng, Shijiao, Shijiao Meng (153050), Wang, Y., Naibai Chang, Xinwei Yu, Zhang, Youjun, Wang, Wei, Huang, Yuqing, Naibai Chang (153067), Yuqing Huang, Qingwei Ma, Yujun Zhang, Youxin Wang (153032), Yuqing Huang (153028), Alan H. Bittles (153071), Li, Yan, Yan Li (23143), Wei Wang (17594), Zhao, Feifei, Chang, N., Bittles, A.H., Yan Li, Song, M., Yujun Zhang (118792), Yu, X., Feifei Zhao (153044), Ma, Qingwei, Wu, J., Zhao, F., Lu, Jiapeng, Bittles, Alan H., Lu, J., Jingjing Wu, Ma, Q., Youxin Wang, Wang, W.   +55 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Healthy aging [PDF]

BMJ, 1997
openaire   +2 more sources