Results 81 to 90 of about 107,517 (316)

Good places for ageing in place : development of objective built environment measures for investigating links with older people's wellbeing [PDF]

, 2011
Background: There is renewed interest in the role of the built environment in public health. Relatively little research to date investigates its impact on healthy ageing. Ageing in place has been adopted as a key strategy for coping with the challenges
Mitchell, Lynne, Burton, E.J., Stride Chris B, Mitchell, L., Stride, C.B., Lynne Mitchell, Burton Elizabeth J, Chris B Stride, Burton, Elizabeth J., Stride, Chris, Mitchell Lynne, Elizabeth J Burton   +11 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Orthopaedic surgeons’ perceptions of frailty and frailty screening

BMC Geriatrics, 2020
Background Over the past decade, there has been significant growth in the awareness and understanding of fragility among orthopaedic surgeons in the context of osteoporotic fractures and with it, improvements in the recognition and management of ...
Mandy M. Archibald, Michael Lawless, Tiffany K. Gill, Mellick J. Chehade   +3 more
doaj   +1 more source

Functional capacity of people with early osteoarthritis: a comparison between subjects from the cohort hip and cohort knee (CHECK) and healthy ageing workers [PDF]

, 2010
The prevalence of osteoarthritis (OA) increases, but the impact of the disorder on peoples' functional capacity is not known. Therefore, the objective of this study was to compare self-reported health status and functional capacity of subjects with early
R. Soer, Reneman, M.F., Soer, R, M. W. van Ittersum, Oostveen, J. C. M., M. F. Reneman, Reneman, M F, Oostveen, J.C.M., Groothoff, J W, H. J. Bieleman, Oosterveld, F G J, van Ittersum, M. W., C. P. van der Schans, J. W. Groothoff, Reneman, M. F., Bieleman, H J, Oosterveld, F.G.J., van der Schans, C.P., van der Schans, C. P., Oostveen, J C M, J. C. M. Oostveen, van der Schans, Cees, Soer, R., Oosterveld, F. G. J., Bieleman, H.J., Soer, R.; id_orcid, Reneman, M. F.; id_orcid, Bieleman, H. J., van Ittersum, Miriam, van Ittersum, M.W., Groothoff, J.W., Groothoff, J. W., F. G. J. Oosterveld   +32 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Promoting Social Participation for Healthy Ageing - A Counterfactual Analysis from the Survey of Health, Ageing, and Retirement in Europe (SHARE) [PDF]

Promoting social participation of the older population (e.g. membership in voluntary associations) is often seen as a promising strategy for 'healthy ageing' in Europe.
Nicolas Sirven, Thierry Debrand
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

HSP90 in ageing progression and ageing related diseases

, 2014
HSP90 activities decline during ageing. Noteworthy, HSP90 mediated retrotransposon silencing seems to have a key role in the maintenance of genome integrity. Furthermore, inhibition of HSP90 activities lead to cell senescence and apoptosis.
ARANCIO, Walter, GIORDANO, Carla, PIZZOLANTI, Giuseppe   +2 more
core  

Interventions to Promote Physical Activity and Healthy Ageing: Special Issue Reprint: [PDF]

The Healthy Ageing Challenge aims for people to enjoy at least five extra healthy independent years of life by 2035 while narrowing the gap between the experiences of the richest and poorest. Regular physical activity is important for healthy ageing, not

core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source