Results 131 to 140 of about 338,464 (302)

Synergistic effects of cognitive frailty and comorbidities on disability: a community-based longitudinal study

BMC Geriatrics
Objective In this study, we aimed to assess the synergistic effects of cognitive frailty (CF) and comorbidity on disability among older adults. Methods Out of the 1318 participants from the Malaysian Towards Useful Aging (TUA) study, only 400 were ...
Nurul Fatin Malek Rivan, Resshaya Roobini Murukesu, Suzana Shahar, Nor Fadilah Rajab, Ponnusamy Subramaniam, Theng Choon Ooi, Mohd Zul Amin Kamaruddin, Devinder Kaur Ajit Singh   +7 more
doaj   +1 more source

Healthy aging [PDF]

BMJ, 1997
openaire   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

UK Data Archive Resources for Studying Older People and Ageing [PDF]

, 2011
There is a growing collection of data available on older people and ageing at the UK Data Archive. Collections include “On the Edge of Later Life”, a study that investigated the experiences of people in their 50’s, and “Older Men: Their Social Worlds and
Bishop, Libby
core  

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

The impact of frailty on the use of social services, medication and mortality risk: a cross-sectional study

BMC Geriatrics
Background Frailty is a common condition in older people, and its prevalence increases with age. With an ageing population, the adverse consequences of frailty cause an increasing appeal to the health care system.
Nanda Kleinenberg-Talsma, Fons van der Lucht, Harriët Jager-Wittenaar, Wim Krijnen, Evelyn Finnema   +4 more
doaj   +1 more source

Towards Age-Friendly Work in Europe: A Life-Course Perspective on Work and Ageing from EU Agencies [PDF]

, 2017
[Excerpt] The European population is ageing owing to decreasing birth rates and increasing longevity. Population ageing is associated with a decrease in the size and ageing of the workforce.
Eurofound, European Agency for Safety and Health and Work, European Centre for the Development of Vocational Training, European Institute for Gender Equality   +3 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Mitochondrial Translation Inhibition Triggers an Rst2-Controlled Transcriptional Reprogramming of Carbon Metabolism in Stationary-Phase Cells of Fission Yeast

Biomolecules
Mitochondria possess their own genome, which encodes subunits of the electron transport chain, rendering mitochondrial protein translation essential for cellular energy metabolism.
Ying Luo, Shaimaa Hassan, Saniya Raut, Jürg Bähler   +3 more
doaj   +1 more source

Age-related changes to lumbosacral spinal cord motoneurons that modulate bladder and bowel functions in male C57BL/6 mice [PDF]

, 2013
Incontinence and sexual dysfunction are often increased in the aged human population. In rats and mice the pattern of micturition and faecal clearance also changes with ageing and is suggestive of bladder and bowel ...
Black, G., Ranson, R. N, Saffrey, M. J., Tsang, H., Zhang, M.   +4 more
core