Results 51 to 60 of about 11,242,010 (306)

Gateway to Global Aging Data: Resources for Cross-National Comparisons of Family, Social Environment, and Healthy Aging.

The journals of gerontology. Series B, Psychological sciences and social sciences, 2021
OBJECTIVES The Gateway to Global Aging Data (Gateway; g2aging.org) is a data and information platform developed to facilitate cross-country analyses on aging, especially those using the international family of Health and Retirement studies.
Jinkook Lee, Drystan F Phillips, J. Wilkens   +2 more
semanticscholar   +1 more source

Impacts and mechanisms of metabolic reprogramming of tumor microenvironment for immunotherapy in gastric cancer

Cell Death and Disease, 2022
Metabolic disorders and abnormal immune function changes occur in tumor tissues and cells to varying degrees. There is increasing evidence that reprogrammed energy metabolism contributes to the development of tumor suppressive immune microenvironment and
Lin Zhao, Yuanyuan Liu, Simiao Zhang, Lingyu Wei, Hongbing Cheng, Jinsheng Wang, Jia Wang   +6 more
doaj   +1 more source

Optimal dietary patterns for healthy aging

Nature Medicine
As the global population ages, it is critical to identify diets that, beyond preventing noncommunicable diseases, optimally promote healthy aging. Here, using longitudinal questionnaire data from the Nurses’ Health Study (1986–2016) and the Health ...
Anne-Julie Tessier, Fenglei Wang, A. A. Korat, A. Eliassen, Jorge E Chavarro, Francine Grodstein, Jun Li, Liming Liang, Walter C Willett, Qi Sun, M. Stampfer, Frank B. Hu, M. Guasch-Ferré   +12 more
semanticscholar   +1 more source

Skeletal muscle transcriptome in healthy aging

Nature Communications, 2021
Age-associated changes in gene expression in skeletal muscle of healthy individuals reflect accumulation of damage and compensatory adaptations to preserve tissue integrity.
Robert A. Tumasian, A. Harish, Gautam Kundu, Jen-Hao Yang, C. Ubaida-Mohien, M. Gonzalez-Freire, M. Kaileh, L. Zukley, C. Chia, A. Lyashkov, W. Wood, Y. Piao, Christopher Coletta, Jun Ding, M. Gorospe, R. Sen, Supriyo De, L. Ferrucci   +17 more
semanticscholar   +1 more source

Dietary protein intake in midlife in relation to healthy aging – results from the prospective Nurses’ Health Study cohort

American Journal of Clinical Nutrition
Background Protein intake plays an important role in maintaining the health status of older adults. However, few epidemiologic studies examined midlife protein intake in relation to healthy aging.
A. A. Korat, Kyla Shea, Paul F. Jacques, Paola Sebastiani, Molin Wang, Heather Eliassen, Walter C Willett, Qi Sun   +7 more
semanticscholar   +1 more source

Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain.

Neurobiology of Aging, 2021
Loss of physiological microglial function may increase the propagation of neurodegenerative diseases. Cellular senescence is a hallmark of aging; thus, we hypothesized age could be a cause of dystrophic microglia.
Ryan K. Shahidehpour, Rebecca E. Higdon, Nicole G. Crawford, J. Neltner, E. Ighodaro, E. Patel, D. Price, P. Nelson, A. Bachstetter   +8 more
semanticscholar   +1 more source

Calcium Binding Mechanism of Soybean Peptide with Histidine Alteration by Molecular Docking Analysis and Spectroscopic Methods

Foods, 2022
Histidine (His) carries a unique heteroaromatic imidazole side chain and plays an irreplaceable role in peptides and proteins. With the current study, we aimed to determine the characteristics and functional activities of the bone density of soy peptide ...
Jing Gan, Xiao Kong, Ziqun Xiao, Yuhang Chen, Mengdi Du, Yan Wang, Zhenhua Wang, Yongqiang Cheng, Bo Xu   +8 more
doaj   +1 more source

Principal component-based clinical aging clocks identify signatures of healthy aging and targets for clinical intervention

Nature Aging
Clocks that measure biological age should predict all-cause mortality and give rise to actionable insights to promote healthy aging. Here we applied dimensionality reduction by principal component analysis to clinical data to generate a clinical aging ...
Sheng Fong, Kamil Pabis, Djakim Latumalea, Nomuundari Dugersuren, M. Unfried, Nicholas Tolwinski, Brian K. Kennedy, Jan Gruber   +7 more
semanticscholar   +1 more source

Healthy Aging-Nutrition Matters: Start Early and Screen Often.

Advances in Nutrition, 2021
The amount of time spent in poor health at the end of life is increasing. This narrative review summarizes consistent evidence indicating that healthy dietary patterns and maintenance of a healthy weight in the years leading to old age are associated ...
S. Roberts, Rachel E. Silver, S. Das, R. Fielding, C. Gilhooly, P. Jacques, Jennifer M Kelly, J. Mason, N. McKeown, Meaghan A Reardon, S. Rowan, E. Saltzman, B. Shukitt-Hale, Caren E. Smith, A. Taylor, Dayong Wu, F. Zhang, K. Panetta, S. Booth   +18 more
semanticscholar   +1 more source

Sedentary Behaviors, Light-Intensity Physical Activity, and Healthy Aging

JAMA Network Open
Key Points Question Besides moderate to vigorous physical activity and sleep, are sedentary behavior and light physical activity independently associated with healthy aging, and how could they be reallocated to promote healthy aging?
Hongying Shi, Frank B. Hu, Tianyi Huang, E. Schernhammer, Walter C Willett, Qi Sun, Molin Wang   +6 more
semanticscholar   +1 more source