Results 111 to 120 of about 2,058,358 (352)

Cardiac Slc25a49‐Mediated Energy Reprogramming Governs Doxorubicin‐Induced Cardiomyopathy through the G6P–AP‐1–Sln Axis

Advanced Science, EarlyView.
Doxorubicin‐induced cardiomyopathy involves mitochondrial energy metabolism dysfunction, exacerbated by cardiomyocyte‐specific Slc25a49 deficiency via oxidative phosphorylation (OXPHOS) suppression and glycolysis activation. The Slc25a49–glucose‐6‐phosphate (G6P)–activator protein‐1 (AP‐1) axis drives myocardial injury by upregulating Sln, disrupting ...
Sitong Wan, Jingyi Qi, Yi Xia, Chang Fan, Teng Xu, Xu Zhang, Jiaxin Shi, Chenxuan Wang, Yitong Cheng, Dongyuan Zhang, Rong Liu, Yinhua Zhu, Changchang Cao, Dekui Jin, Peng An, Yongting Luo, Junjie Luo   +16 more
wiley   +1 more source

Cardiometabolic Phenotype in HFpEF: Insights from Murine Models

Biomedicines
Heart failure with preserved ejection fraction (HFpEF) remains a significant challenge in modern healthcare. It accounts for the majority of heart failure cases and their number worldwide is steadily increasing.
Ekaterina Ogurtsova, Tatiana Arefieva, Anastasiia Filatova, Natalya Radyukhina, Artem Ovchinnikov   +4 more
doaj   +1 more source

An evaluation of service expansion to include patients with heart failure with preserved ejection fraction

Background/Aims The Central London Community Healthcare Trust West Hertfordshire heart failure service expanded in 2020 to include patients with heart failure with preserved ejection fraction in addition to the patients with heart failure with reduced ...
Peplow, J., Peplow, J., Rees, S., Rees, S.   +3 more
core   +2 more sources

Advanced Microfluidic‐Based Wearable Electrochemical Sensors for Continuous Biochemical Monitoring

Advanced Electronic Materials, EarlyView.
Microfluidic‐based wearable electrochemical sensors are transforming non‐invasive health monitoring through real‐time biochemical analysis of sweat, saliva, and interstitial fluid. This review explores advances in microfluidic design, fabrication, and sensor integration while addressing biofluid variability, material compatibility, and scalability.
Sehyun Park, Seongyeop Kim, Soojin Lee, Vladimir V. Tsukruk, SeungHyun Park, Hyo‐Ryoung Lim   +5 more
wiley   +1 more source

Role of global longitudinal strain in assessment of left ventricular systolic function in patients with heart failure with preserved ejection fraction

Journal of the Saudi Heart Association, 2019
Objectives: To detect systolic dysfunction in heart failure with preserved ejection fraction (HFpEF) patients by using global longitudinal strain (GLS).
Hasanain Ali Hameed Bshiebish, Ali Hussein Al-Musawi, Safaa Ali Khudeir   +2 more
doaj  

Central and Obstructive Apneas in Heart Failure With Reduced, Mid-Range and Preserved Ejection Fraction

Frontiers in Cardiovascular Medicine, 2019
Background: Although central apneas (CA) and obstructive apneas (OA) are highly prevalent in heart failure (HF), a comparison of apnea prevalence, predictors and clinical correlates in the whole HF spectrum, including HF with reduced ejection fraction ...
Chiara Borrelli, Chiara Borrelli, Chiara Borrelli, Francesco Gentile, Paolo Sciarrone, Gianluca Mirizzi, Gianluca Mirizzi, Giuseppe Vergaro, Giuseppe Vergaro, Nicolò Ghionzoli, Francesca Bramanti, Giovanni Iudice, Claudio Passino, Claudio Passino, Michele Emdin, Michele Emdin, Alberto Giannoni, Alberto Giannoni   +17 more
doaj   +1 more source

Cell Membrane‐Coated Lipid Nanoparticles for Drug Delivery

Aggregate, EarlyView.
This review highlights recent progress in cell membrane‐coated lipid nanoparticles (CMC‐LNPs), focusing on their design, preparation methods, functional integration, and biomedical applications. It discusses various types of LNPs and coating strategies, characterization techniques, therapeutic functions, and applications.
Moataz B. Zewail, Guangze Yang, Yilong Fan, Yue Hui, Chun‐Xia Zhao, Yun Liu   +5 more
wiley   +1 more source

Relationship Between Dietary Magnesium Intake and Incident Heart Failure Among Older Women: The WHI

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Women represent a large proportion of the growing heart failure (HF) epidemic, yet data are lacking regarding optimal dietary and lifestyle prevention strategies for them.
Wen‐Chih Wu, Mengna Huang, Tracey H. Taveira, Mary B. Roberts, Lisa W. Martin, Gregory A. Wellenius, Karen C. Johnson, JoAnn E. Manson, Simin Liu, Charles B. Eaton   +9 more
doaj   +1 more source

ASB1 differential methylation in ischaemic cardiomyopathy. Relationship with left ventricular performance in end stage heart failure patients [PDF]

arXiv, 2017
Aims: Ischaemic cardiomyopathy (ICM) leads to impaired contraction and ventricular dysfunction causing high rates of morbidity and mortality. Epigenomics allows the identification of epigenetic signatures in human diseases. We analyse the differential epigenetic patterns of ASB gene family in ICM patients and relate these alterations to their ...
arxiv  

A Phase II Trial of Geriatric Assessment‐Guided Selection of Treatment Intensity in Older Adults With AML

American Journal of Hematology, EarlyView.
ABSTRACT How to select the appropriate intensity of chemotherapy in older adults with acute myeloid leukemia (AML) remains an unanswered question. In a phase II trial of older adults ≥ 60 years with AML (n = 73), we used geriatric assessment (measures of comorbidity burden, physical and cognitive function) to determine fitness for intensive ...
Vijaya R. Bhatt, Christopher S. Wichman, Thuy T. Koll, Alfred L. Fisher, Tanya M. Wildes, Michael Haddadin, Ann M. Berger, James O. Armitage, Sarah A. Holstein, Lori J. Maness, Krishna Gundabolu   +10 more
wiley   +1 more source