Results 151 to 160 of about 6,994,494 (255)

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

Role of Antioxidant Systems and Heat Shock Response in Aquatic Animals Under Multistress Conditions. [PDF]

Antioxidants (Basel)
Feidantsis K, Minari M, Cubillos V, Dijkstra PD, Buzinski ODK, Moreira DC, Hermes-Lima M.   +6 more
europepmc   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Abiotic Stresses Induce Heat Shock Factors to Regulate Small Heat Shock Protein Genes Expression in Arabidopsis thaliana

, 2007
熱逆境為植物的環境逆境之一，隨著溫室效應造成全球暖化日趨嚴重，也因此成為重要的關切議題。當植物暴露於熱逆境時，會產生共同的生理反應來抵抗高溫逆境，此反應稱為熱休克反應(heat shock response)，會大量合成一群新的蛋白質來保護細胞，這些蛋白質稱為熱休克蛋白(heat shock proteins, HSPs)，其中以低分子量熱休克蛋白(small HSPs, sHSPs)的種類與數量為最多，而sHSPs的合成被認為是經由熱休克轉錄因子(heat shock factors, HSFs ...
Huang, Tsung-Chih, 黃琮智
core  

Changes in both gene expression and intron retention tune the <i>Arabidopsis thaliana</i> heat shock response. [PDF]

MicroPubl Biol
Huang Y, Kaplinsky N.
europepmc   +1 more source

(p)ppGpp - an important player during heat shock response. [PDF]

Microlife, 2023
Driller K, Cornejo FA, Turgay K.
europepmc   +1 more source

Heat Stress Promotes Fibroblast‐Derived WNT5A Secretion Through m6A Modification to Activate Melanogenesis

Advanced Science, EarlyView.
Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan, Yaqing Wen, Yushan Zhang, Lan Zhang, Jianjian Zhu, Zhen Tang, Ling Jiang, Chuhan Fu, Shu Zhou, Keyi Zhang, Jiangfeng Huang, Li Lei, Jing Chen, Qinghai Zeng   +13 more
wiley   +1 more source

Heat stress reveals bidirectional cross talk between the heat shock response and UPRER in C. elegans. [PDF]

G3 (Bethesda)
Alcala A, Castro Torres T, Aviles Barahona R, Frankino PA, Higuchi-Sanabria R, Garcia G.   +5 more
europepmc   +1 more source

Unlocking Low‐Melting‐Point and High‐Conductivity Molten Salts via High‐Entropy Strategy with Demonstration in Thermal Batteries

Advanced Science, EarlyView.
A high‐entropy strategy is developed to break the trade‐off between low melting point and high ionic conductivity in molten salt electrolytes. By incorporating CsBr and LiF into the LiCl‐LiBr‐KBr system, the quinary LiF‐LiCl‐LiBr‐KBr‐CsBr electrolyte achieves a record‐low melting point of 229.5°C while maintaining a high conductivity of 1.19 S cm−1 at ...
Binchao Shi, Ting Sun, Fushan Yu, Yi Zhang, Gaowu Wang, Ting Quan, Yan‐li Zhu   +6 more
wiley   +1 more source

An Important Role for RPRD1B in the Heat Shock Response. [PDF]

Mol Cell Biol, 2022
Cugusi S, Bajpe PK, Mitter R, Patel H, Stewart A, Svejstrup JQ.   +5 more
europepmc   +1 more source