Results 171 to 180 of about 6,994,494 (255)

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Conservation of mRNA operon formation in control of the heat shock response in mammalian cells. [PDF]

Sci Adv
Pataki E, Gerst JE.
europepmc   +1 more source

Resistance to Gemcitabine in Pancreatic Cancer Is Connected to Methylglyoxal Stress and Heat Shock Response. [PDF]

Cells, 2023
Crake R, Gasmi I, Dehaye J, Lardinois F, Peiffer R, Maloujahmoum N, Agirman F, Koopmansch B, D'Haene N, Azurmendi Senar O, Arsenijevic T, Lambert F, Peulen O, Van Laethem JL, Bellahcène A.   +14 more
europepmc   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

γ-Aminobutyric Acid (GABA) enhances heat tolerance in rice via integrated antioxidant defense, metabolic homeostasis and heat shock response. [PDF]

BMC Plant Biol
Wang Y, Wang J, Wang F, Meng T, Liu X, Ruan B, Wu L, Yu Y, Chen F.   +8 more
europepmc   +1 more source

Amplifying the Heat Shock Response Ameliorates ALS and FTD Pathology in Mouse and Human Models. [PDF]

Mol Neurobiol, 2023
Ahmed M, Spicer C, Harley J, Taylor JP, Hanna M, Patani R, Greensmith L.   +6 more
europepmc   +1 more source

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

The Neuronal Heat Shock Response

Heat shock, which refers to abrupt increases in environmental temperature, induces a cascade of cellular stress responses called the heat shock response (HSR).
Seluzicki, Caitlin Marie
core   +1 more source

TOR and heat shock response pathways regulate peroxisome biogenesis during proteotoxic stress. [PDF]

Nat Commun
Shukla N, Neal ML, Farré JC, Mast FD, Sarkar R, Truong L, Simon T, Miller LR, Aitchison JD, Subramani S.   +9 more
europepmc   +1 more source

HSP70 mediates a crosstalk between the estrogen and the heat shock response pathways. [PDF]

J Biol Chem, 2023
Silveira MAD, Khadangi F, Mersaoui SY, Naik D, Masson JY, Bilodeau S.   +5 more
europepmc   +1 more source