BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer
BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu +12 more
wiley +1 more source
Modulation of host proteostasis by Prevotella corporis via induction of the heat shock response. [PDF]
Tibi MF +8 more
europepmc +1 more source
Unipolar Barrier Near‐Infrared 2D Photodetectors for 3D Image Sensors
A MoTe2/WSe2/Cl–SnSe2 unipolar barrier photodetector is demonstrated, in which the WSe2 layer effectively blocks majority‐carrier injection, yielding suppressed dark current and enhanced near‐infrared (NIR) sensing. The device achieves high detectivity, a wide linear dynamic range, and fast response under 1310 nm illumination, enabling high‐fidelity 3D
Jung Pyo Hong +21 more
wiley +1 more source
Functional impact of a conservative missense mutation in the Mycobacterium bovis BCG Moreau heat shock response regulator hrcA gene. [PDF]
Gomes LHF +4 more
europepmc +1 more source
Planar Ag/MAPbI3 thin single‐crystal halide perovskite devices show ultralow dark current and optically tunable threshold switching. Illumination enhances the polarity‐dependent hysteresis and shifts the switching voltage, whereas temperature‐dependent measurements reveal thermally activated, contact‐limited transport, underscoring the central role of ...
Ofelia Durante +16 more
wiley +1 more source
Characterisation of the thermal and non-thermal stress conditions that activate the Plasmodium falciparum AP2-HS-dependent heat-shock response. [PDF]
Ràfols N +4 more
europepmc +1 more source
Transcriptional regulation of Sis1 promotes fitness but not feedback in the heat shock response. [PDF]
Garde R, Singh A, Ali A, Pincus D.
europepmc +1 more source
Advancing Energy Efficiency in Smart Windows via Dual‐Responsive Electro‐Thermochromism
A durable and stable quasi‐solid‐state electro‐thermal dual‐responsive photothermal regulation device has been employed in advanced energy‐efficient smart windows. The devised device not only incorporates a thermochromic hydrogel characterized by high ionic conductivity, high optical transmittance, and a low LCST, but also comprises an electrochromic ...
Tongyu Chen +10 more
wiley +1 more source
熱休克反應為生物體內普遍存在的逆境抵抗機制,會誘導數群分子量不同的熱休克蛋白質(heat shock protein, HSP)產生,以進行細胞保護。植物中低分子量熱休克蛋白質(small HSP, sHSP)的累積與種類是已知物種最多的一群HSP。關於高溫誘導表現的機制,已知會由一群熱休克因子(heat shock factor, HSF)來調控。阿拉伯芥與水稻中,分別具有包含A、B、C三個類群的21個和25個HSF基因成員,顯示在高等生物對於HSP表現的調控極為複雜 ...
李宗遠, Lee, Tsung-Yuan
core
Mechanosensor-mediated Hsp70 phosphorylation orchestrates the landscape of the heat shock response. [PDF]
Omkar S +7 more
europepmc +1 more source

