Results 181 to 190 of about 568,583 (300)

TOR and heat shock response pathways regulate peroxisome biogenesis during proteotoxic stress. [PDF]

Nat Commun
Shukla N, Neal ML, Farré JC, Mast FD, Sarkar R, Truong L, Simon T, Miller LR, Aitchison JD, Subramani S.   +9 more
europepmc   +1 more source

Inhibition of TRAP1 Accelerates the DNA Damage Response, Activation of the Heat Shock Response and Metabolic Reprogramming in Colon Cancer Cells. [PDF]

Front Biosci (Landmark Ed), 2023
Bhasin N, Dabral P, Senavirathna L, Pan S, Chen R.   +4 more
europepmc   +1 more source

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

Advanced Science, EarlyView.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su, Meng Yang, Xinfeng Wang, Pa Wu, Zongzhao Zhai   +4 more
wiley   +1 more source

GLA-3 mediates the heat shock response in Caenorhabditis elegans germ cells: A key role for the tristetraprolin (TTP) family. [PDF]

PLoS One
Salinas LS, Dámazo-Hernández ÁA, Cristino-Miranda AM, Zurita-León M, Morales-Oliva E, Láscarez-Lagunas LI, Navarro RE.   +6 more
europepmc   +1 more source

Lessons Learned from Two Decades of Modeling the Heat-Shock Response. [PDF]

Biomolecules, 2022
Ranawade A, Sharma R, Levine E.
europepmc   +1 more source

Localized NF‐κB Inhibition Reduces Lipid Nanoparticle‐Associated Inflammation

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) activate NF‐κB and provoke inflammation that limits therapeutic delivery. By encapsulating selective NF‐κB inhibitors within LNPs, localized suppression of inflammatory signaling is achieved without compromising mRNA expression.
Carolann L. Espy, Jichuan Wu, Serena Omo‐Lamai, Liuqian Wang, Fengyi Dong, Aleksa Milosavljevic, Sarah O'Neill, Taylor Brysgel, Yufei Wang, Michael Zaleski, Emily Wolfe, Rhea Maheshwari, Manthan Patel, Dirk Trauner, Jia Nong, Zhicheng Wang, Jacob S. Brenner   +16 more
wiley   +1 more source

The Heat Shock Response Under Natural Conditions in Two Paper Wasp Species. [PDF]

Insects
Amstrup AB, Kovac H, Käfer H, Stabentheiner A, Sørensen JG.   +4 more
europepmc   +1 more source

The heat shock response and small molecule regulators. [PDF]

Eur J Med Chem, 2021
Kurop MK, Huyen CM, Huyen CM, Kelly JH, Blagg BSJ.   +4 more
europepmc   +1 more source

Engineered Bacteria Factory Integrating Drug Delivery and Antibody Manufacture for Activating the STING Signal Pathway Mediated Tumor Immunotherapy

Advanced Science, EarlyView.
To address the limitations of protein‐based ICIs in applications, this study constructed an engineered bacterium, HRB, capable of expressing aCD47 in hypoxic TME. Through the Schiff base reaction, responsive liposomes (LC) loaded with the STING agonist cGAMP were connected to the surface of bacteria to form HRB@LC.
Peng‐Shuo Dong, Tian Yao, Yong Li, Zi‐Hui Yan, Xiao‐Ting Xie, Jia‐Hua Zou, Kai Cheng, Jin‐Xuan Fan, Yuan‐Di Zhao, Qiu‐Ran Xu   +9 more
wiley   +1 more source

Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response. [PDF]

Elife
Ruger-Herreros C, Svoboda L, Male G, Shrivastava A, Höpfler M, Jetzinger K, Koubek J, Kramer G, den Brave F, Mogk A, Gross DS, Bukau B.   +11 more
europepmc   +1 more source