Results 151 to 160 of about 202,314 (262)

A Modular PLUG‐IN Photosynthetic Chassis With Tunable Thermal Control for Mammalian Systems

Advanced Science, EarlyView.
This work establishes a “plug‐in” chassis compatible with mammalian systems that synchronizes growth, production, and cell‐wall re‐configuration, providing a versatile platform for photosynthetic bioproduction and microalgal synthetic biology. ABSTRACT Microalgae are promising photosynthetic platforms for high‐value compounds, yet their industrial use ...
Qinhua Gan, Zheng Li, Yunfei Chen, Mingting Du, Qianyi Wu, Congcong Miao, Tao Xu, Shan Wu, Xitao Chen, Xingwei Huang, Yuhui Cheng, Chengcheng Li, Yi Xin, Yandu Lu   +13 more
wiley   +1 more source

<i>ACTA2</i> Pathogenic Variants Activating Heat Shock Factor 1 and Increasing Cholesterol Biosynthesis in Smooth Muscle Cells Predispose to Early Onset Atherosclerosis. [PDF]

Circ Genom Precis Med
Boerio ML, Chattopadhyay A, Duan XY, Karla A, Calderon Martinez E, Pinard A, Morse AK, Reddy D, Dharma S, Velasco-Torrez W, Marcadier J, Prakash SK, Shalhub S, De Backer J, Jeremy R, Morris SA, Yetman AT, Braverman AC, Milewicz DM.   +18 more
europepmc   +1 more source

Heat-Induced Conformational Transition Mechanism of Heat Shock Factor 1 Investigated by Tryptophan Probe. [PDF]

Biochemistry, 2022
Kawagoe S, Kumashiro M, Mabuchi T, Kumeta H, Ishimori K, Saio T.   +5 more
europepmc   +1 more source

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

Promoter and domain swap analysis delineates heat stress memory-specific determinants of heat shock factor HSFA2. [PDF]

Plant Physiol
Oberkofler V, Baltzer J, Szymanski W, Bäurle I.   +3 more
europepmc   +1 more source

Inhibition of Heat Shock Factor 1 Signaling Decreases Hepatoblastoma Growth via Induction of Apoptosis. [PDF]

Am J Pathol, 2023
Hurley EH, Tao J, Liu S, Krutsenko Y, Singh S, Monga SP.   +5 more
europepmc   +1 more source

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Clinical significance and potential mechanism of heat shock factor 1 in acute myeloid leukemia. [PDF]

Aging (Albany NY), 2022
Lyu C, Wang Q, Yin X, Li Z, Wang T, Wang Y, Cui S, Liu K, Wang Z, Gao C, Xu R.   +10 more
europepmc   +1 more source

Non‐Equilibrium Synthesis of Whitlockite Assisted by Localized H2O Vapor Pressure

Advanced Science, EarlyView.
A carbon substrate acts as a microheater during intense pulsed light irradiation, enabling rapid heating and cooling for whitlockite formation. In contrast to conventional white ceramic synthesis with weak photothermal response, this platform concentrates thermal energy locally and promotes phase‐selective crystallization under ultrafast ...
Min‐Jung Kim, Minwoo Lee, In‐Ho Jung, Seung‐Kyun Kang, Ji‐Soo Jang, Hyung‐Seop Han   +5 more
wiley   +1 more source

Hyperbaric oxygen pretreatment on endothelial cell injury via heat shock factor 1 in decompression sickness. [PDF]

Front Mol Biosci
Xu C, Zhou Q, Meng X, Zhou J, Yu X, Zheng J, Yi H, Huang G, Xu W.   +8 more
europepmc   +1 more source