Results 221 to 230 of about 202,314 (262)
Some of the next articles are maybe not open access.
The Phosphorylation of the Heat Shock Factor as a Modulator for the Heat Shock Response
IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2011The heat shock response is a well-conserved defence mechanism against the accumulation of misfolded proteins due to prolonged elevated heat. The cell responds to heat shock by raising the levels of heat shock proteins (hsp), which are responsible for chaperoning protein refolding.
Rogojin, Vladimir +3 more
openaire +6 more sources
Heat Shock Transcription Factors: Structure and Regulation
Annual Review of Cell and Developmental Biology, 1995Organisms respond to elevated temperatures and to chemical and physiological stresses by an increase in the synthesis of heat shock proteins. The regulation of heat shock gene expression in eukaryotes is mediated by the conserved heat shock transcription factor (HSF).
Carl Wu
exaly +3 more sources
Roles of heat shock factor 1 beyond the heat shock response
Cellular and Molecular Life Sciences, 2018Various stress factors leading to protein damage induce the activation of an evolutionarily conserved cell protective mechanism, the heat shock response (HSR), to maintain protein homeostasis in virtually all eukaryotic cells. Heat shock factor 1 (HSF1) plays a central role in the HSR. HSF1 was initially known as a transcription factor that upregulates
Barna János +2 more
openaire +3 more sources
Roles of heat shock factors in gametogenesis and development
FEBS Journal, 2010Heat shock factors form a family of transcription factors (four in mammals), which were named according to the first discovery of their activation by heat shock. As a result of the universality and robustness of their response to heat shock, the stress‐dependent activation of heat shock factor became a ‘paradigm’: by binding to conserved DNA sequences (
Valerie Mezger
exaly +4 more sources
Heat shock factor and the heat shock response
Cell, 1991Peter K. Sorger Department of Microbiology and Immunology University of California San Francisco, California 94143-0502 The induction of eukaryotic heat shock genes in response to a temperature upshift is mediated by the binding of a transcriptional activator, heat shock factor, to a short highly conserved DNA sequence known as the heat shock element ...
openaire +2 more sources
Intracellular trafficking of heat shock factor 2
Experimental Cell Research, 2004HSF2 is an enigmatic member of the heat shock factor family, identified in the homeotherm classes of birds and mammals. We report the characterization of HSF2 from an evolutionary ancient vertebrate, the fish rainbow trout (rtHSF2). rtHSF2 appears closely related to its mammalian counterparts at structural and functional levels. The conservation of the
Le Goff, Pascale +5 more
openaire +3 more sources
Purification of heat shock transcription factor of Drosophila
1996Publisher Summary This chapter discusses the purification of heat-shock transcription factor of Drosophila. All living organisms respond to elevated temperatures, and to a variety of chemical and physiological stresses by a rapid and transient increase in the synthesis of heat-shock proteins.
M, Zhong +6 more
openaire +2 more sources
Inhibition of Heat Shock Transcription Factor by GR
Molecular Endocrinology, 2001The GR is a hormone-activated transcription factor that acts to regulate specific gene expression. In the absence of hormone, the GR and other steroid receptors have been shown to form complexes with several mammalian heat shock proteins. As heat shock proteins are produced by cells as an adaptive response to stress, speculation has existed that ...
S A, Wadekar +3 more
openaire +2 more sources
Heat Shock Inhibits Activation of NF-κB in the Absence of Heat Shock Factor-1
Biochemical and Biophysical Research Communications, 2002The heat shock response is known to inhibit NF-kappaB activation and NF-kappaB-dependent gene expression. Herein we determined if cells lacking heat shock factor-1 (HSF-1), the major transcription factor regulating heat shock protein gene expression, have an altered ability to modulate NF-kappaB activation.
Vivek, Malhotra +5 more
openaire +2 more sources
Role of Heat Shock Transcriptional Factor 1 and Heat Shock Proteins in Cardiac Hypertrophy
Trends in Cardiovascular Medicine, 2008Cardiac hypertrophy is an independent risk factor for cardiovascular disease. Initially, cardiac hypertrophy is an adaptive response to increased wall stress, but sustained stress leads to heart failure. It remains unclear how the transition from adaptive cardiac hypertrophy to maladaptive cardiac hypertrophy occurs.
Haruhiro, Toko +2 more
openaire +2 more sources