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Advanced Science, EarlyView.This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon +21 more
wiley +1 more source
Advanced Science, EarlyView.We developed a RhPd‐H nanozyme that integrates enhanced POD‐mimetic catalytic activity with thermally triggered H2 release. H2 shields and reprograms mitochondria to continuously leak endogenous ·O2−. This dual‐path ROS spatially and temporally disrupts redox homeostasis, inducing persistent oxidative stress for tumor suppression and antitumor immunity,
Mingfan Shi +12 more
wiley +1 more source
Roles of heat shock factor 1 beyond the heat shock response
Cellular and Molecular Life Sciences, 2018 Various stress factors leading to protein damage induce the activation of an evolutionarily conserved cell protective mechanism, the heat shock response (HSR), to maintain protein homeostasis in virtually all eukaryotic cells. Heat shock factor 1 (HSF1) plays a central role in the HSR. HSF1 was initially known as a transcription factor that upregulates
Barna János +2 more
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Roles of the heat shock transcription factors in regulation of the heat shock response and beyond
FASEB Journal, 2001ABSTRACT The heat shock response, characterized by increased expression of heat shock proteins (Hsps) is induced by exposure of cells and tissues to extreme conditions that cause acute or chronic stress. Hsps function as molecular chaperones in regulating cellular homeostasis and promoting survival.
Lea Sistonen
exaly +3 more sources
Heat Shock Transcription Factors: Structure and Regulation
Annual Review of Cell and Developmental Biology, 1995Organisms respond to elevated temperatures and to chemical and physiological stresses by an increase in the synthesis of heat shock proteins. The regulation of heat shock gene expression in eukaryotes is mediated by the conserved heat shock transcription factor (HSF).
Carl Wu
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Roles of heat shock factors in gametogenesis and development
FEBS Journal, 2010Heat shock factors form a family of transcription factors (four in mammals), which were named according to the first discovery of their activation by heat shock. As a result of the universality and robustness of their response to heat shock, the stress‐dependent activation of heat shock factor became a ‘paradigm’: by binding to conserved DNA sequences (
Valérie Mezger
exaly +4 more sources
EMBO Journal, 2020 The heat shock response is a universal transcriptional response to proteotoxic stress orchestrated by heat shock transcription factor Hsf1 in all eukaryotic cells.
Szymon W Kmiecik +2 more
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Molecular mechanisms of heat shock factor 1 regulation.
TIBS -Trends in Biochemical Sciences. Regular ed, 2021To thrive and to fulfill their functions, cells need to maintain proteome homeostasis even in the face of adverse environmental conditions or radical restructuring of the proteome during differentiation.
Szymon W. Kmiecik, M. Mayer
semanticscholar +1 more source
The Phosphorylation of the Heat Shock Factor as a Modulator for the Heat Shock Response
IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2011The heat shock response is a well-conserved defence mechanism against the accumulation of misfolded proteins due to prolonged elevated heat. The cell responds to heat shock by raising the levels of heat shock proteins (hsp), which are responsible for chaperoning protein refolding.
Rogojin, Vladimir +3 more
openaire +6 more sources