Results 301 to 310 of about 948,615 (346)

A combined modelling and experimental study of heat shock factor SUMOylation in response to heat shock

Journal of Theoretical Biology, 2021
One of the most important questions in cell biology is how cell fate is determined when exposed to extreme stresses such as heat shock. It has been long understood that organisms exposed to high temperature stresses typically protect themselves with a heat shock response (HSR), where accumulation of denatured or unfolded proteins triggers the synthesis
Manyu Zhang, Alice Zhao, Chun Guo, Lingzhong Guo   +3 more
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Heat shock factor and the heat shock response

Cell, 1991
Peter K. Sorger Department of Microbiology and Immunology University of California San Francisco, California 94143-0502 The induction of eukaryotic heat shock genes in response to a temperature upshift is mediated by the binding of a transcriptional activator, heat shock factor, to a short highly conserved DNA sequence known as the heat shock element ...
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Intracellular trafficking of heat shock factor 2

Experimental Cell Research, 2004
HSF2 is an enigmatic member of the heat shock factor family, identified in the homeotherm classes of birds and mammals. We report the characterization of HSF2 from an evolutionary ancient vertebrate, the fish rainbow trout (rtHSF2). rtHSF2 appears closely related to its mammalian counterparts at structural and functional levels. The conservation of the
Le Goff, Pascale, Le Dréan, Yves, Le Péron, Christine, Le Jossic-Corcos, Catherine, Aïnouche, Abdelkader, Michel, Denis   +5 more
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Inhibition of Heat Shock Transcription Factor by GR

Molecular Endocrinology, 2001
The GR is a hormone-activated transcription factor that acts to regulate specific gene expression. In the absence of hormone, the GR and other steroid receptors have been shown to form complexes with several mammalian heat shock proteins. As heat shock proteins are produced by cells as an adaptive response to stress, speculation has existed that ...
S A, Wadekar, D, Li, S, Periyasamy, E R, Sánchez   +3 more
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Heat Shock Inhibits Activation of NF-κB in the Absence of Heat Shock Factor-1

Biochemical and Biophysical Research Communications, 2002
The heat shock response is known to inhibit NF-kappaB activation and NF-kappaB-dependent gene expression. Herein we determined if cells lacking heat shock factor-1 (HSF-1), the major transcription factor regulating heat shock protein gene expression, have an altered ability to modulate NF-kappaB activation.
Vivek, Malhotra, Tonyia, Eaves-Pyles, Kelli, Odoms, Gina, Quaid, Thomas P, Shanley, Hector R, Wong   +5 more
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Role of Heat Shock Transcriptional Factor 1 and Heat Shock Proteins in Cardiac Hypertrophy

Trends in Cardiovascular Medicine, 2008
Cardiac hypertrophy is an independent risk factor for cardiovascular disease. Initially, cardiac hypertrophy is an adaptive response to increased wall stress, but sustained stress leads to heart failure. It remains unclear how the transition from adaptive cardiac hypertrophy to maladaptive cardiac hypertrophy occurs.
Haruhiro, Toko, Tohru, Minamino, Issei, Komuro   +2 more
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Purification of heat shock transcription factor of Drosophila

1996
Publisher Summary This chapter discusses the purification of heat-shock transcription factor of Drosophila. All living organisms respond to elevated temperatures, and to a variety of chemical and physiological stresses by a rapid and transient increase in the synthesis of heat-shock proteins.
M, Zhong, J, Wisniewski, M, Fritsch, G, Mizuguchi, A, Orosz, P, Jedlicka, C, Wu   +6 more
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Activation of heat-shock transcription factor in rat heart after heat shock and exercise

American Journal of Physiology-Cell Physiology, 1995
Stress-induced transcriptional regulation of the heat-shock proteins (HSP) is mediated by activation and binding of the heat-shock transcription factors (HSF) to the heat-shock element (HSE). Given the similarities between the stressors known to activate the HSF in cultured cells and the physiological stresses known to occur during exercise, HSF ...
M, Locke, E G, Noble, R M, Tanguay, M R, Feild, S E, Ianuzzo, C D, Ianuzzo   +5 more
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The Role of Heat Shock Factors in Mammalian Spermatogenesis

2017
Heat shock transcription factors (HSFs), as regulators of heat shock proteins (HSPs) expression, are well known for their cytoprotective functions during cellular stress. They also play important yet less recognized roles in gametogenesis. All HSF family members are expressed during mammalian spermatogenesis, mainly in spermatocytes and round ...
Wieslawa, Widlak, Natalia, Vydra
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Heat Shock Protein and Heat Shock Factor Expression in Sperm: Relation to Oligozoospermia and Varicocele

Journal of Urology, 2010
Varicocele may be associated with normozoospermia or oligozoospermia. Much controversy still exists regarding the diagnosis, management and pathophysiology of spermatogenesis alterations associated with varicocele. The increased temperature induced by varicocele and stress in general may activate heat shock proteins and heat shock factors with a ...
FERLIN, ALBERTO, SPELTRA E, PATASSINI C, PATI MA, GAROLLA A, CARETTA N, FORESTA, CARLO   +6 more
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