Results 51 to 60 of about 270,723 (313)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Association of serum-soluble heat shock protein 60 with carotid atherosclerosis: clinical significance determined in a follow-up study

, 2005
BACKGROUND AND PURPOSE: Previous work has shown that soluble heat shock protein 60 (HSP60; sHSP60), present in circulating blood, is associated with carotid atherosclerosis.
Mandal, K, Georg Wick, Mayr, M; id_orcid, Willeit, J, Xu, Q B, Qingzhong Xiao, Kiechl, S, Friedrich Oberhollenzer, Mayr, M, XIAO, Q, Georg Schett, Stefan Kiechl, Qingbo Xu, Wick, G, Johann Willeit, Kaushik Mandal, Oberhollenzer, F, Schett, G, Xiao, Q Z, Manuel Mayr, XU, Q   +20 more
core   +1 more source

Heat shock protein-90-alpha, a prolactin-STAT5 target gene identified in breast cancer cells, is involved in apoptosis regulation [PDF]

, 2008
Introduction The prolactin-Janus-kinase-2-signal transducer and activator of transcription-5 (JAK2-STAT5) pathway is essential for the development and functional differentiation of the mammary gland.
Liu, R., Bork, Peer, Shemanko, Carrie S., Shemanko, C., Liu, Ruixuan, Pfitzner, Edith, Schultz, J., Christine T Parusel, Jörg Schultz, Groner, Bernd, Parusel, Christine T., Bork, P., Boecher, N., Perotti, Christian, Christian Perotti, Ruixuan Liu, Carrie S Shemanko, Pfitzner, E., Groner, B., Schultz, Jörg, Bernd Groner, Böcher, Nadine, Nadine Böcher, Perotti, C., Peer Bork, Edith Pfitzner, Parusel, C.   +26 more
core   +1 more source

Candidate stress biomarkers for queen failure diagnostics

BMC Genomics, 2020
Background Queen failure is a persistent problem in beekeeping operations, but in the absence of overt symptoms it is often difficult, if not impossible, to ascertain the root cause. Stressors like heat-shock, cold-shock, and sublethal pesticide exposure
Alison McAfee, Joseph Milone, Abigail Chapman, Leonard J. Foster, Jeffery S. Pettis, David R. Tarpy   +5 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Bacterial Infection Elicits Heat Shock Protein 72 Release from Pleural Mesothelial Cells [PDF]

, 2013
Heat shock protein 70 (HSP70) has been implicated in infection-related processes and has been found in body fluids during infection. This study aimed to determine whether pleural mesothelial cells release HSP70 in response to bacterial infection in vitro
Porcel, JM, Bielsa, S, Brown, JS, della Vergiliana, JFV, Temple, SEL, Waterer, GW, Lee, YCG, Lansley, SM, Creaney, J   +8 more
core  

Heat shock inhibits lipopolysaccharide-induced tissue factor activity in human whole blood

, 2007
Background During gram-negative sepsis, lipopolysaccharide (LPS) induces tissue factor expression on monocytes. The resulting disseminated intravascular coagulation leads to tissue ischemia and worsens the prognosis of septic patients.
Thielmann, Matthias, Christoph Sucker, Zacharowski, Kai, Hartmann, Matthias, Kai Zacharowski, Matthias Thielmann, Sucker, Christoph, Sucker Christoph, Thielmann Matthias, Matthias Hartmann, Zacharowski Kai, Hartmann Matthias   +11 more
core   +1 more source

Hsp70 in mitochondrial biogenesis [PDF]

, 1994
The family of hsp70 (70 kilodalton heat shock protein) molecular chaperones plays an essential and diverse role in cellular physiology, Hsp70 proteins appear to elicit their effects by interacting with polypeptides that present domains which exhibit non ...
Stuart, Rosemary A., Neupert, Walter, Cyr, Douglas M.   +2 more
core   +1 more source

CUL-6/cullin ubiquitin ligase-mediated degradation of HSP-90 by intestinal lysosomes promotes thermotolerance

Cell Reports
Summary: Heat shock can be a lethal stressor. Previously, we described a CUL-6/cullin-ring ubiquitin ligase complex in the nematode Caenorhabditis elegans that is induced by intracellular intestinal infection and proteotoxic stress and that promotes ...
Mario Bardan Sarmiento, Spencer S. Gang, Patricija van Oosten-Hawle, Emily R. Troemel   +3 more
doaj   +1 more source

Systemic analysis of heat shock response induced by heat shock and a proteasome inhibitor MG132. [PDF]

PLoS ONE, 2011
The molecular basis of heat shock response (HSR), a cellular defense mechanism against various stresses, is not well understood. In this, the first comprehensive analysis of gene expression changes in response to heat shock and MG132 (a proteasome ...
Hee-Jung Kim, Hye Joon Joo, Yung Hee Kim, Soyeon Ahn, Jun Chang, Kyu-Baek Hwang, Dong-Hee Lee, Kong-Joo Lee   +7 more
doaj   +1 more source