Results 31 to 40 of about 413,998 (350)
Nature Communications, 2019 Osteoarthritis (OA) is a whole-joint disease characterized by cartilage destruction and other whole-joint pathological changes. There is currently no effective disease-modifying therapy.
Young-Ok Son +4 more
semanticscholar +1 more source
Heat Shock Cognate Protein 70 Regulates Gephyrin Clustering [PDF]
The Journal of Neuroscience, 2011 Formation and stabilization of postsynaptic glycine receptor (GlyR) clusters result from their association with the polymerized scaffold protein gephyrin. At the cell surface, lateral diffusion and local trapping of GlyR by synaptic gephyrin clusters is one of the main factors controlling their number.
Patricia, Machado +7 more
openaire +2 more sources
Alʹmanah Kliničeskoj Mediciny, 2016 The levels of urinary heat shock protein-70 and serum antibodies to the heat shock protein-70 were assessed in 79 patients with different course variants of the chronic glomerulonephritis. The indices studied were higher in patients with an active course
N. V. Chebotaryova +3 more
doaj +1 more source
Pharmaceutical Biology, 2022 Context Vascular calcification is a major complication of chronic renal failure, which has been identified as an active process partly driven by osteogenic transition of vascular smooth muscle cells (VSMCs).
Quanquan Shen +7 more
doaj +1 more source
Journal of Medicinal Chemistry, 2018 Cancer cells rely on the chaperone heat shock protein 70 (Hsp70) for survival and proliferation. Recently, benzothiazole rhodacyanines have been shown to bind an allosteric site on Hsp70, interrupting its binding to nucleotide-exchange factors (NEFs) and
H. Shao +12 more
semanticscholar +1 more source
Investigation of heat shock protein 70 gene polymorphism in Khuzestan native chickens [PDF]
مجله بیوتکنولوژی کشاورزی, 2020 Objective Heat shock protein 70 (Hsp70) are a family of molecular chaperones, which promote protein folding and participate in many cellular functions. The purpose of the study was to identify the polymorphisms of heat shock protein 70 gene of Khuzestan ...
Mahmood Nazari +2 more
doaj +1 more source
Thermodynamic bounds on the ultra- and infra-affinity of Hsp70 for its substrates [PDF]
, 2017 The 70 kDa Heat Shock Proteins Hsp70 have several essential functions in living systems, such as protecting cells against protein aggregation, assisting protein folding, remodeling protein complexes and driving the translocation into organelles.
Hartich, David +3 more
core +2 more sources
Intracellular Heat Shock Protein 70 Deficiency in Pulmonary Fibrosis.
American Journal of Respiratory Cell and Molecular Biology, 2019 Idiopathic pulmonary fibrosis (IPF) pathogenesis has been postulated to involve a variety of mechanisms associated with the aging process, including loss of protein homeostasis (proteostasis).
J. Sellarés +8 more
semanticscholar +1 more source
Serum levels of Heat Shock Protein-70 in Patients with Oral Lichen Planus
Balkan Journal of Dental Medicine, 2014 Usually increased presence of Heat Shock Proteins (HSPs) is considered to mediate inflammation process in Oral Lichen Planus (OLP) lesions, but in contrast HSP-70 expression found to be stable or even decreased in those lesions. The purpose of this study
Albanidou-Farmaki E. +4 more
doaj +1 more source
Heat shock stimulation of a tilapia heat shock protein 70 promoter is mediated by a distal element [PDF]
, 2001 peer reviewedWe reported previously that a tilapia (Oreochromis mossambicus) heat shock protein 70 (HSP70) promoter is able to confer heat shock response on a reporter gene after transient expression both in cell culture and in microinjected zebrafish ...
Di Martino, Emmanuel +3 more
core +2 more sources