Results 171 to 180 of about 310,958 (294)

Multifunctional Nano Immunostimulant: Overcoming Immunosuppressive Microenvironment for Antitumor Immunotherapy

Advanced Science, EarlyView.
A multifunctional nano immunostimulant is first proposed for efficient tumor immunotherapy. The ER targeted ability, superior ROS production, efficient GSH consumption, coupled with the HIF suppression, jointly arouses ICD/ferroptosis pathways to realize efficient tumor immunotherapy.
Guanhong Guo, Wenda Zhong, Huishuang Zhao, Yueying An, Xinyu Dong, Zhengbo Li, Shuangfeng Qin, Guangzhao Xu, Xiangguo Yue, Xudong Wang, Wen Sun, Zhe‐Sheng Chen, Weiguo Song, Liuya Wei, Fahui Li   +14 more
wiley   +1 more source

Preliminary investigation of heat shock protein 90 gene diversity in Echinococcus granulosus sensu lato: a potential nuclear marker for species identification. [PDF]

Parasitol Res
Lamia Z, Myriam OM, Raja CB, Ines K, Umhang G, Hedi AM, Taoufik S, Marwa M, Lassaad S, Boué F, Hamouda B, Selim M.   +11 more
europepmc   +1 more source

m1A‐Dependent TRMT6/61A‐ARG2 Axis Drives Protumorigenic Senescence by Remodeling the Tumor Microenvironment

Advanced Science, EarlyView.
Uncovering a new layer of translational control, this study reveals how TRMT6/TRMT61A‐mediated tRNA‐m1A methylation drives pro‐tumorigenic senescence in colorectal cancer. By selectively enhancing ARG2 translation, this epitranscriptomic axis triggers an NF‐κB‐dependent SASP.
Tuoyang Li, Mingzhe Huang, Jinlin Cai, Xuan Li, Yaokang Xing, Rongzhao He, Zixiao Wan, Yingguo Gan, Ziming Li, Jingrong Weng, Yumo Xie, Yuanhui Wu, Xiaoxia Liu, Xiaolin Wang, Yanxin Luo, Meijin Huang, Jinxin Lin, Huichuan Yu   +17 more
wiley   +1 more source

Association Study of the Heat Shock Protein 90 Alpha (<i>HSP90AA1</i>) Gene Polymorphisms with Schizophrenia in a Polish Population. [PDF]

Genes (Basel)
Kowalczyk M, Owczarek AJ, Kucia K, Hasterok M, Suchanek-Raif R, Paul-Samojedny M, Lakomy W, Kowalski J.   +7 more
europepmc   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

In vivo imaging of heat shock protein 90: Diagnostic tool and support for Hsp90-targeted therapy. [PDF]

Cell Stress Chaperones
Cools R, Vermeulen K, Bormans G.
europepmc   +1 more source

Retracted: A Study of Heat Shock Protein 90 and Serum CCL21 Expression in Pregnant Women with Preeclampsia. [PDF]

Evid Based Complement Alternat Med, 2023
And Alternative Medicine EC.
europepmc   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

A Xanthine Derivative With Novel Heat Shock Protein 90-Alpha Inhibitory and Senolytic Properties. [PDF]

Aging Cell
Atlante S, Cis L, Pirolli D, Gottardi Zamperla M, Barbi V, Mai A, Zwergel C, Marcozzi S, Giuliani ME, Bigossi G, Lai G, Orlando F, Giacconi R, Lattanzio F, Matacchione G, Giordani C, Bracci M, Olivieri F, Boschi F, Tabarelli De Fatis P, Ivaldi GB, Malavolta M, Farsetti A, De Rosa MC, Gaetano C.   +24 more
europepmc   +1 more source

Role of heat shock protein 90 as an antiviral target for swine enteric coronaviruses. [PDF]

Virus Res, 2023
Zhao Z, Zhang YQ, Xu LD, Xiao L, Feng Y, Wang B, Huang YW.   +6 more
europepmc   +1 more source