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Roles of the heat shock transcription factors in regulation of the heat shock response and beyond
The FASEB Journal, 2001ABSTRACT The heat shock response, characterized by increased expression of heat shock proteins (Hsps) is induced by exposure of cells and tissues to extreme conditions that cause acute or chronic stress. Hsps function as molecular chaperones in regulating cellular homeostasis and promoting survival.
L, Pirkkala, P, Nykänen, L, Sistonen
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Purification of heat shock transcription factor of Drosophila
1996Publisher Summary This chapter discusses the purification of heat-shock transcription factor of Drosophila. All living organisms respond to elevated temperatures, and to a variety of chemical and physiological stresses by a rapid and transient increase in the synthesis of heat-shock proteins.
M, Zhong +6 more
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Role of Heat Shock Transcriptional Factor 1 and Heat Shock Proteins in Cardiac Hypertrophy
Trends in Cardiovascular Medicine, 2008Cardiac hypertrophy is an independent risk factor for cardiovascular disease. Initially, cardiac hypertrophy is an adaptive response to increased wall stress, but sustained stress leads to heart failure. It remains unclear how the transition from adaptive cardiac hypertrophy to maladaptive cardiac hypertrophy occurs.
Haruhiro, Toko +2 more
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Activation of heat-shock transcription factor in rat heart after heat shock and exercise
American Journal of Physiology-Cell Physiology, 1995Stress-induced transcriptional regulation of the heat-shock proteins (HSP) is mediated by activation and binding of the heat-shock transcription factors (HSF) to the heat-shock element (HSE). Given the similarities between the stressors known to activate the HSF in cultured cells and the physiological stresses known to occur during exercise, HSF ...
M, Locke +5 more
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1996
The inducible regulation of heat shock gene transcription is mediated by a family of heat shock factors (HSF) that respond to diverse forms of physiological and environmental stress including elevated temperature, amino acid analogs, heavy metals, oxidative stress, anti-inflammatory drugs, arachidonic acid, and a number of pathophysiological disease ...
R I, Morimoto, P E, Kroeger, J J, Cotto
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The inducible regulation of heat shock gene transcription is mediated by a family of heat shock factors (HSF) that respond to diverse forms of physiological and environmental stress including elevated temperature, amino acid analogs, heavy metals, oxidative stress, anti-inflammatory drugs, arachidonic acid, and a number of pathophysiological disease ...
R I, Morimoto, P E, Kroeger, J J, Cotto
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Role of Heat Shock Factors in Stress-Induced Transcription: An Update
2023Heat shock proteins (HSP) are rapidly induced after proteotoxic stresses such as heat shock and accumulate at high concentrations in cells. HSP induction involves primarily a family of heat shock transcription factors (HSF) that bind the heat shock elements of the HSP genes and mediate transcription in trans.
Heyoun, Bunch, Stuart K, Calderwood
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Regulatory domain of human heat shock transcription Factor-2 is not regulated by hemin or heat shock
Journal of Cellular Biochemistry, 1999Heat shock transcription factor 2 (HSF-2) activates transcription of heat shock proteins in response to hemin in the human erythroleukemia cell line, K562. To understand the regulation of HSF-2 activation, a series of deletion mutants of HSF-2 fused to the GAL-4 DNA binding domain were generated.
Z, Zhu, N F, Mivechi
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Expression and Purification of Human Heat-Shock Transcription Factor 1
Protein Expression and Purification, 1997Heat-shock factor 1 (HSF1) is a 57-kDa cytoplasmic protein which binds to the promoters of heat-shock genes and activates transcription during heat shock. We describe here the expression and purification of the 529 amino acids form of human HSF1. We designed a new and complete purification protocol involving ammonium sulfate precipitation, heparin ...
Soncin, Fabrice +2 more
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Bending of promoter DNA on binding of heat shock transcription factor
Nature, 1986The Drosophila heat-shock transcription factor (HSTF) has been shown to bind to three domains of the heat shock protein 70 gene (hsp 70) control region. The most critical of these for transcriptional activation appears to be the one closest to the TATA-homology region.
D J, Shuey, C S, Parker
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In vitro activation of heat shock transcription factor by 4-hydroxynonenal
Chemico-Biological Interactions, 1992In the activation of eukaryotic heat shock genes, the acquisition of a binding ability to specific DNA sequence by a transcriptional activator, heat shock factor (HSF), is believed to be a crucial step. The induction of this new DNA binding activity of HSF is also obtained in a cell-free system (in vitro activation) by hyperthermia or at physiological ...
F, Cajone, M, Crescente
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