An RNF4-Based Tool for Tracking Subcellular Localization of PolySUMOylation During Cellular Stress. [PDF]
BiomoleculesFloramo JS +5 more
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Heat shock factor regulation of antimicrobial peptides expression suggests a conserved defense mechanism induced by febrile temperature in arthropods. [PDF]
ElifeXiao B +5 more
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Decoding the functions of nuclear speckles in neurodegeneration. [PDF]
Trends NeurosciChen X, Zhu B.
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Heat Shock Transcription Factors: Structure and Regulation
Annual Review of Cell and Developmental Biology, 1995Organisms respond to elevated temperatures and to chemical and physiological stresses by an increase in the synthesis of heat shock proteins. The regulation of heat shock gene expression in eukaryotes is mediated by the conserved heat shock transcription factor (HSF).
Carl Wu
exaly +3 more sources
Roles of the heat shock transcription factors in regulation of the heat shock response and beyond
The FASEB Journal, 2001ABSTRACT The heat shock response, characterized by increased expression of heat shock proteins (Hsps) is induced by exposure of cells and tissues to extreme conditions that cause acute or chronic stress. Hsps function as molecular chaperones in regulating cellular homeostasis and promoting survival.
L, Pirkkala, P, Nykänen, L, Sistonen
openaire +2 more sources
Purification of heat shock transcription factor of Drosophila
1996Publisher Summary This chapter discusses the purification of heat-shock transcription factor of Drosophila. All living organisms respond to elevated temperatures, and to a variety of chemical and physiological stresses by a rapid and transient increase in the synthesis of heat-shock proteins.
M, Zhong +6 more
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Role of Heat Shock Transcriptional Factor 1 and Heat Shock Proteins in Cardiac Hypertrophy
Trends in Cardiovascular Medicine, 2008Cardiac hypertrophy is an independent risk factor for cardiovascular disease. Initially, cardiac hypertrophy is an adaptive response to increased wall stress, but sustained stress leads to heart failure. It remains unclear how the transition from adaptive cardiac hypertrophy to maladaptive cardiac hypertrophy occurs.
Haruhiro, Toko +2 more
openaire +2 more sources
Activation of heat-shock transcription factor in rat heart after heat shock and exercise
American Journal of Physiology-Cell Physiology, 1995Stress-induced transcriptional regulation of the heat-shock proteins (HSP) is mediated by activation and binding of the heat-shock transcription factors (HSF) to the heat-shock element (HSE). Given the similarities between the stressors known to activate the HSF in cultured cells and the physiological stresses known to occur during exercise, HSF ...
M, Locke +5 more
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The inducible regulation of heat shock gene transcription is mediated by a family of heat shock factors (HSF) that respond to diverse forms of physiological and environmental stress including elevated temperature, amino acid analogs, heavy metals, oxidative stress, anti-inflammatory drugs, arachidonic acid, and a number of pathophysiological disease ...
R I, Morimoto, P E, Kroeger, J J, Cotto
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Regulatory domain of human heat shock transcription Factor-2 is not regulated by hemin or heat shock
Journal of Cellular Biochemistry, 1999Heat shock transcription factor 2 (HSF-2) activates transcription of heat shock proteins in response to hemin in the human erythroleukemia cell line, K562. To understand the regulation of HSF-2 activation, a series of deletion mutants of HSF-2 fused to the GAL-4 DNA binding domain were generated.
Z, Zhu, N F, Mivechi
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