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Clinics in Laboratory Medicine, 1986
A review of alpha-heavy chain disease (AHCD) emphasizing its histopathology and associated lesions is presented. Unusual clinicopathologic presentations and modern concepts regarding histogenesis of AHCD in the light of recent immunohistochemical findings are discussed.
Parviz Haghighi, Paul L. Wolf
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A review of alpha-heavy chain disease (AHCD) emphasizing its histopathology and associated lesions is presented. Unusual clinicopathologic presentations and modern concepts regarding histogenesis of AHCD in the light of recent immunohistochemical findings are discussed.
Parviz Haghighi, Paul L. Wolf
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Clinical Lymphoma Myeloma and Leukemia, 2020
Heavy chain disorders are rare B-cell disorders and include heavy chain disease, heavy chain deposition disease, and heavy chain amyloidosis. These disorders share the pathognomonic finding of a truncated immunoglobulin heavy chain without an associated light chain in the serum or urine in the case of heavy chain disease or in the tissues in the case ...
Sara Singer +7 more
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Heavy chain disorders are rare B-cell disorders and include heavy chain disease, heavy chain deposition disease, and heavy chain amyloidosis. These disorders share the pathognomonic finding of a truncated immunoglobulin heavy chain without an associated light chain in the serum or urine in the case of heavy chain disease or in the tissues in the case ...
Sara Singer +7 more
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1986
Heavy chain diseases (HCD) are immunoproliferative disorders characterized by the production of monoclonal immunoglobulin molecules composed of deleted heavy chains devoid of light chains. The diagnosis is established by immunoelectrophoresis (possibly combined to immunoselection) or immunofixation.
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Heavy chain diseases (HCD) are immunoproliferative disorders characterized by the production of monoclonal immunoglobulin molecules composed of deleted heavy chains devoid of light chains. The diagnosis is established by immunoelectrophoresis (possibly combined to immunoselection) or immunofixation.
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Analysis of patients with γ-heavy chain disease by the heavy/light chain and free light chain assays
Clinical Chemistry and Laboratory Medicine, 2014The objective of this study was to evaluate the performance of the heavy/light chain and free light chain immunoassays in patients with heavy chain disease, and to assess the ability of the heavy/light chain assay to measure and confirm the abnormal, truncated heavy chain.Frozen serum samples from 15 γ-heavy chain disease patients were tested for IgGκ,
Robert A. Kyle +3 more
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The Physics Teacher, 2011
While perusing various websites in search of a more challenging lab for my students, I came across a number of ideas where replacing the string in an Atwood's machine1 with a simple ball chain like the kind found in lamp pulls created an interesting system to investigate.
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While perusing various websites in search of a more challenging lab for my students, I came across a number of ideas where replacing the string in an Atwood's machine1 with a simple ball chain like the kind found in lamp pulls created an interesting system to investigate.
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La Ricerca in Clinica e in Laboratorio, 1976
Human heavy chain diseases offer an opportunity to examine the molecular events taking place in cells which produce naturally occurring structural variants of a well-studied complex protein. Extensive structural analyses have been carried out on many of these proteins and have revealed the existence of certain characteristic features.
Joel N. Buxbaum, Joel N. Buxbaum
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Human heavy chain diseases offer an opportunity to examine the molecular events taking place in cells which produce naturally occurring structural variants of a well-studied complex protein. Extensive structural analyses have been carried out on many of these proteins and have revealed the existence of certain characteristic features.
Joel N. Buxbaum, Joel N. Buxbaum
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European Journal of Immunology, 1978
AbstractUsing cultured mouse myeloma cells, it has been possible to derive cells which are now synthesizing products similar to human heavy chain disease proteins. An initial mutant was isolated which synthesized a heavy chain with an internal deletion and a normal light chain.
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AbstractUsing cultured mouse myeloma cells, it has been possible to derive cells which are now synthesizing products similar to human heavy chain disease proteins. An initial mutant was isolated which synthesized a heavy chain with an internal deletion and a normal light chain.
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Production of Chimeric Heavy-Chain Antibodies
2008Antibody has become a major category of therapeutics. However, IgG, the primary molecular format of existing antibody drugs, has some major shortcomings such as undesirable pharmacokinetics, high dose requirement, and high production cost, partially due to its large molecular size.
Zhang, Jianbing +2 more
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Functional heavy-chain antibodies in camelidae
2001Publisher Summary This chapter focuses on the steps that are involved in the ontogeny of a heavy-chain antibody (HCAb), starting from distinct genes. HCAb is defined as an immunoglobulin devoid of light (L) chains. The presence of HCAbs in human serum is reported as a pathological disorder. It seems that, besides the absence of L chain, the heavy (H)
Nguyen, Viet Khong +2 more
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1991
The heavy chain disease is a “true” form of paraproteinemia. The existance of the μ, γ, and α heavy chain disease is well documented. The δ-type heavy chain seems to be a special form of a IgD-myeloma (20, 102). The immunochemical differences within the — μ, γ, α — are accompanied with specific clinical symptoms.
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The heavy chain disease is a “true” form of paraproteinemia. The existance of the μ, γ, and α heavy chain disease is well documented. The δ-type heavy chain seems to be a special form of a IgD-myeloma (20, 102). The immunochemical differences within the — μ, γ, α — are accompanied with specific clinical symptoms.
openaire +2 more sources