Results 91 to 100 of about 8,581 (234)

Quantification of 10B and 11B in Biological Samples in Translational Science and Clinical Applications for Boron Neutron Capture Therapy (BNCT)

Medicinal Research Reviews, EarlyView.
ABSTRACT Boron neutron capture therapy (BNCT) is a targeted radiotherapy that exploits the selective accumulation of the 10B isotope within tumors, followed by irradiation with low‐energy neutrons to induce high linear energy transfer particles with short path lengths, resulting in localized tumor cell destruction while sparing surrounding healthy ...
Christoph Selg, Wolfgang A. G. Sauerwein, Evamarie Hey‐Hawkins   +2 more
wiley   +1 more source

Analysis of the Dose Drop at the Edge of the Target Area in Heavy Ion Radiotherapy. [PDF]

Comput Math Methods Med, 2021
Ma X, Zhang M, Meng W, Lu X, Wang Z, Zhang Y.   +5 more
europepmc   +1 more source

Heavy-ion radiotherapy with HIMAC

, 2017
Heavy-ion beams are very suitable for the treatment of deeply seated cancer because of an excellent physical-dose distribution and high biological effect around the Bragg peak. Heavy-Ion Medical Accelerator in Chiba, HIMAC, therefore, was constructed for
722101, 野田 耕司, 722102, Noda, Koji   +3 more
core  

1.Status of ion sources at HIMAC 2.Status on heavy ion radiotherapy facilities and related ion sources

, 2010
Since 1994, heavy-ion radiotherapy using carbon ions is successfully carried out with the Heavy Ion Medical Accelerator in Chiba (HIMAC) at the National Institute of Radiological Sciences (NIRS).
北川 敦志, 631306, Kitagawa, Atsushi, 631305   +3 more
core   +1 more source

Heavy-Particle Radiotherapy: System Design and Application

, 2009
The requirements for an accelerator and a beam-delivery system for medical application are described(pointing out terms of heavy-particle radiotherapy), based on 15 years of experience with carbon-ion radiotherapy at HIMAC.
Noda, Kouji, Minohara, Shinichi, Tsujii, Hirohiko, 454519, 454518, 454517, 459124, 459126, 辻井 博彦, 野田 耕司, 459125, 454521, 459128, 454520, 459127   +14 more
core  

113. Cellular survival as the common denominator between heavy-ion and photon beam radiotherapy

, 2003
Experimental data on cellular survival in vitro often serve as a radiobiological basis for modeling and interpreting the clinical results of “classical” cancer radiotherapy, using external photon and electron beams.
Lesiak, J., M.P.R. Waligórski, Waligórski, M.P.R., J. Lesiak   +3 more
core   +1 more source

Safety, efficacy, pharmacokinetics, and mechanisms of novel 10B‐boronophenylalanine combined with a radio‐frequency quadrupole accelerator in boron neutron capture therapy: A preclinical study in head and neck squamous cell carcinoma

Precision Radiation Oncology, EarlyView.
This study demonstrates that the novel 10B‐BPA‐based BNCT system, combined with an RFQ accelerator, effectively targets head and neck squamous cell carcinoma. It induces tumor regression safely and efficiently by triggering DNA damage and activating the ROS/HIF‐1α/NF‐κB pathway, leading to caspase‐3‐mediated apoptosis.
Zhaoyuan Zhang, Junyan Li, Minhua Fan, Huafu Ouyang, Qiubo Chu, Huijie Yan, Yannan Zheng, Linxuan Huang, Gui Bao, Zhenting Ma, Shaobo Huang, Lin Li, Xiao Xu, Zhigang Liu   +13 more
wiley   +1 more source

Development of heavy-ion radiotherapy facility in Japan

, 2015
Heavy-ion beams are very suitable for deeply-seated cancer treatment not only owing to their high dose localization around the Bragg peak, but also owing to the high biological effect there.
721774, 野田 耕司, Noda, Koji, 721773   +3 more
core  

Peptide‐based responsive molecular fluorescent probes for precision oncology

Responsive Materials, EarlyView.
Peptide‐based responsive fluorescent probes have emerged as adaptive functional materials for precision tumor theranostics, combining tumor‐selective recognition, programmable stimulus responsiveness, and modular tunability. They enable high‐contrast imaging, intraoperative guidance, real‐time monitoring, and multimodal applications, while next ...
Xing Wang, Wen Liu, Jiahao Zhang, Wanqi Wang, Zhicheng Jin, Yuqi Tang, Quan Li   +6 more
wiley   +1 more source

Radiation Physics and Chemistry in Heavy-ion Cancer Therapy [PDF]

Kemija u Industriji, 2007
Heavy ions, such as carbon and oxygen ions, are classified as high-LET radiations, and produce a characteristic dose-depth distribution different from that of low-LET radiations such as γ-rays, xrays and electrons.
Kimura, M., Krajcar Bronic, I.
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