Results 1 to 10 of about 2,488,943 (332)

Linear Energy Transfer Incorporated Spot-Scanning Proton Arc Therapy Optimization: A Feasibility Study [PDF]

Frontiers in Oncology, 2021
PurposeTo integrate dose-averaged linear energy transfer (LETd) into spot-scanning proton arc therapy (SPArc) optimization and to explore its feasibility and potential clinical benefits.MethodsAn open-source proton planning platform (OpenREGGUI) has been
Xiaoqiang Li, Xuanfeng Ding, Weili Zheng, Gang Liu, Gang Liu, Guillaume Janssens, Kevin Souris, Ana M. Barragán-Montero, Di Yan, Craig Stevens, Peyman Kabolizadeh   +10 more
doaj   +3 more sources

Comparison of the Medical Uses and Cellular Effects of High and Low Linear Energy Transfer Radiation [PDF]

Toxics, 2022
Exposure to ionizing radiation can occur during medical treatments, from naturally occurring sources in the environment, or as the result of a nuclear accident or thermonuclear war.
Eric Russ, Catherine M. Davis, John E. Slaven, Dmitry T. Bradfield, Reed G. Selwyn, Regina M. Day   +5 more
doaj   +3 more sources

High-Linear Energy Transfer Irradiation in Clinical Carbon-Ion Beam With the Linear Energy Transfer Painting Technique for Patients With Head and Neck Cancer. [PDF]

Adv Radiat Oncol, 2023
Purpose Dose-averaged linear energy transfer (LETd) is one of the important factors in determining clinical outcomes for carbon-ion radiation therapy. Innovative LET painting (LP) has been developed as an advanced form of conventional intensity modulated
Kohno R, Koto M, Ikawa H, Lee SH, Sato K, Hashimoto M, Inaniwa T, Shirai T.   +7 more
europepmc   +2 more sources

A Dosiomics Analysis Based on Linear Energy Transfer and Biological Dose Maps to Predict Local Recurrence in Sacral Chordomas after Carbon-Ion Radiotherapy. [PDF]

Cancers (Basel), 2022
Simple Summary The poor tumor characterization and the lack of prognostic biomarkers hinder the efficacy and the personalization of treatments for Sacral Chordomas (SC), for which Carbon Ion Radiotherapy (CIRT) is one of the most promising therapeutic ...
Morelli L, Parrella G, Molinelli S, Magro G, Annunziata S, Mairani A, Chalaszczyk A, Fiore MR, Ciocca M, Paganelli C, Orlandi E, Baroni G.   +11 more
europepmc   +2 more sources

Brain Necrosis in Adult Patients After Proton Therapy: Is There Evidence for Dependency on Linear Energy Transfer? [PDF]

Int J Radiat Oncol Biol Phys, 2021
PURPOSE To investigate if radiographic imaging changes defined as necrosis correlate with regions in the brain with elevated linear energy transfer (LET) for proton radiation therapy treatments with partial brain involvement in central nervous system ...
Niemierko A, Schuemann J, Niyazi M, Giantsoudi D, Maquilan G, Shih HA, Paganetti H.   +6 more
europepmc   +2 more sources

Impact of dose calculation accuracy on inverse linear energy transfer optimization for intensity‐modulated proton therapy [PDF]

Precision Radiation Oncology, 2023
Objective To determine the effect of dose calculation accuracy on inverse linear energy transfer (LET) optimization for intensity‐modulated proton therapy, and to determine whether adding more beams would improve the plan robustness to different dose ...
Mei Chen, Wenhua Cao, Pablo Yepes, Fada Guan, Falk Poenisch, Cheng Xu, Jiayi Chen, Yupeng Li, Ivan Vazquez, Ming Yang, X. Ronald Zhu, Xiaodong Zhang   +11 more
doaj   +2 more sources

Linear energy transfer-independent calibration of radiochromic film for carbon-ion beams [PDF]

Physics and Imaging in Radiation Oncology, 2022
For carbon-ion beams, radiochromic film response depends on the dose and linear energy transfer (LET). For film dosimetry, we developed an LET-independent simple calibration method for a radiochromic film for specific therapeutic carbon-ion beams.
Mutsumi Tashiro, Motohiro Kawashima
doaj   +2 more sources

Radiation-Induced Cardiovascular Disease: Mechanisms and Importance of Linear Energy Transfer

Frontiers in Cardiovascular Medicine, 2018
Radiation therapy (RT) in the form of photons and protons is a well-established treatment for cancer. More recently, heavy charged particles have been used to treat radioresistant and high-risk cancers.
Christopher B. Sylvester, Christopher B. Sylvester, Jun-ichi Abe, Zarana S. Patel, K. Jane Grande-Allen   +4 more
doaj   +2 more sources

Advancing Proton Beam Dosimetry in Water: A Particle and Heavy Ion Transport Code System Monte Carlo Simulation of Depth Dose, Range Characteristics, and Linear Energy Transfer Distributions [PDF]

Journal of Medical Physics
Aim: Proton therapy is a cutting-edge radiation oncology technique that uses the Bragg peak to deliver highly localized radiation doses to tumors while minimizing exposure to nearby healthy tissues.
M. Sholaiman, Md. Raihan Islam, M. Rafiqul Islam, M. M. Haque   +3 more
doaj   +2 more sources

Enabling clinical use of linear energy transfer in proton therapy for head and neck cancer – A review of implications for treatment planning and adverse events study [PDF]

Visualized Cancer Medicine
Proton therapy offers significant advantages due to its unique physical and biological properties, particularly the Bragg peak, enabling precise dose delivery to tumors while sparing healthy tissues.
Chen Jingyuan, Yang Yunze, Feng Hongying, Liu Chenbin, Zhang Lian, Holmes Jason M., Liu Zhengliang, Lin Haibo, Liu Tianming, Simone Charles B., Lee Nancy Y., Frank Steven J., Ma Daniel J., Patel Samir H., Liu Wei   +14 more
doaj   +2 more sources