Results 101 to 110 of about 718,149 (279)

Investigational agents in metastatic basal cell carcinoma: focus on vismodegib

Journal of Experimental Pharmacology, 2012
Nicolas Batty,1 Ellen Kossoff,2 Grace K Dy11Department of Medicine, Roswell Park Cancer Center, Buffalo, NY, USA; 2Department of Pharmacy, Roswell Park Cancer Center, Buffalo, NY, USAAbstract: Vismodegib (GDC-0449, 2-chloro-N-(4-chloro-3-(pyridin-2-yl ...
Batty N, Kossoff E, Dy GK
doaj  

Differential sensitivity to SHH signaling and neural crest‐mediated Gas1 expression regulate jaw size during development and evolution

Developmental Dynamics, EarlyView.
Abstract Background Developmental control of jaw size is crucial to prevent birth defects and facilitate evolutionary adaptation. We have shown that jaw size is established by neural crest mesenchyme (NCM), which are progenitor cells that migrate into the mandibular primordia and produce the jaws.
Zuzana Vavrušová, Daniel B. Chu, An Nguyen, Yeniko Ta, Jennifer L. Fish, Richard A. Schneider   +5 more
wiley   +1 more source

Reinduction of Hedgehog Inhibitors after Checkpoint Inhibition in Advanced Basal Cell Carcinoma: A Series of 12 Patients. [PDF]

Cancers (Basel), 2022
DeTemple VK, Hassel JC, Sachse MM, Grimmelmann I, Leiter U, Gebhardt C, Eckardt J, Pföhler C, Angela Y, Hübbe H, Gutzmer R.   +10 more
europepmc   +1 more source

Hedgehog inhibitor in scGVHD Supplement

Supplement material for Efficacy of Hedgehog Pathway Inhibitors as Adjuvant in Treating Steroid-Refractory Sclerodermatous Chronic Graft-Versus-Host Disease: Methods and Supplement ...
Weng, Wen-Kai
core   +1 more source

Hedgehog signaling inhibitors as anti-cancer agents in osteosarcoma [PDF]

, 2015
Osteosarcoma is a rare type of cancer associated with a poor clinical outcome. Even though the pathologic characteristics of OS are well established, much remains to be understood, particularly at the molecular signaling level.
Ram Kumar, Kumar, Ram Mohan Ram, Bruno Fuchs, Fuchs, Bruno, Kumar RM, Fuchs B   +5 more
core   +1 more source

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source

Drug Delivery Systems for Hedgehog Inhibitors in the Treatment of SHH-Medulloblastoma. [PDF]

Front Chem, 2021
Caimano M, Lospinoso Severini L, Loricchio E, Infante P, Di Marcotullio L.   +4 more
europepmc   +1 more source

“Nature's Polymer Reimagined: Conventional and Green Routes to Pectin, Its Bioactive Promise and Industrial Applications”

Food Chemistry International, EarlyView.
Pectin, a versatile natural polymer, is extracted through conventional and emerging green extraction methods, offering multifunctional bioactive properties useful in food, pharmaceutical, and environmental applications. ABSTRACT Pectin, a molecular tapestry woven from diverse polysaccharides, holds a pivotal role across food, pharmaceutical, and ...
Afra Anika Rafique, Aunwesha Sahani, Md Morsaline Billah, Kazi Mohammed Didarul Islam   +3 more
wiley   +1 more source

Hedgehog Pathway and Programmed Cell Death Protein-1 Inhibitors for Advanced Basal Cell Carcinoma

Case Reports in Dermatology
Introduction: Basal cell carcinoma (BCC) is treated with local surgery or noninvasive treatment modalities. If a BCC remains untreated, it can develop into a locally advanced BCC or a metastatic BCC.
Babette J.A. Verkouteren, An K.L. Reyners, Maureen J.B. Aarts, Klara Mosterd   +3 more
doaj   +1 more source

Switching Hedgehog inhibitors and other strategies to address resistance when treating advanced basal cell carcinoma. [PDF]

Oncotarget, 2021
Doan HQ, Chen L, Nawas Z, Lee HH, Silapunt S, Migden M.   +5 more
europepmc   +1 more source