Results 111 to 120 of about 718,149 (279)

Aerobic, Metal-Free, and Catalytic Dehydrogenative Coupling of Heterocycles: En Route to Hedgehog Signaling Pathway Inhibitors

, 2018
The nitrosonium ion-catalyzed dehydrogenative coupling of heteroarenes under mild reaction conditions is reported. The developed method utilizes ambient molecular oxygen as a terminal oxidant, and only water is produced as byproduct.
Luis Bering (1581433), Bering, L., Felix M. Paulussen, Andrey P. Antonchick, Felix M. Paulussen (4972189), Luis Bering, Paulussen, F., Antonchick, A., Andrey P. Antonchick (1528963), Bering, Luis, Antonchick, Andrey P., Paulussen, Felix M.   +11 more
core   +1 more source

Activated hedgehog gene pattern correlates with dismal clinical outcome and tumor microenvironment heterogeneity in hepatocellular carcinoma

Heliyon
Background: Activation of the Hedgehog signaling pathway is linked to the initiation and development of human hepatocellular carcinoma (HCC). However, its impact on clinical outcomes and the HCC microenvironment remains unclear.
Limin Zhen, Yi Zhu, Zhen Wu, Jinyao Liao, Liaoyuan Deng, Qianqian Ma, Qili Wu, Gang Ning, Qiuxiong Lin, Liya Zhou, Yanjie Huang, Zewei Zhuo, Ren Chen, Dongnan Yu   +13 more
doaj   +1 more source

Current Perspectives in the Treatment of Locally Advanced Basal Cell Carcinoma

Drug Design, Development and Therapy, 2022
Neha Gupta, Emily S Ruiz Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Jamaica Plain, MA, USACorrespondence: Emily S RuizDepartment of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, 1153 Centre ...
Gupta N, Ruiz ES
doaj  

Systemic hedgehog inhibitors to treat locally advanced basal cell carcinomas of the head-neck region: A retrospective study. [PDF]

Dermatol Ther, 2021
Villani A, Costa C, Fabbrocini G, Scalvenzi M.   +3 more
europepmc   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Efficacy of sonic hedgehog inhibitors rechallenge, after initial complete response in recurrent advanced basal cell carcinoma: a retrospective study from the CARADERM database. [PDF]

ESMO Open, 2021
Bassompierre A, Dalac S, Dreno B, Neidhardt EM, Maubec E, Capelle C, Andre F, Behal H, Dziwniel V, Bens G, Leccia MT, Meyer N, Granel-Brocard F, Beylot-Barry M, Dereure O, Basset-Seguin N, Mortier L.   +16 more
europepmc   +1 more source

Hepatocyte‐Centered Regulation of MASH Fibrosis: From Animal Models to Molecular Mechanisms and Targeted Therapies

iNew Medicine, EarlyView.
This review highlights hepatocytes as active regulators of MASH fibrosis through secreted proteins, metabolites, and extracellular vesicles that modulate hepatic stellate cell activation. These hepatocyte–stellate cell communication pathways provide a mechanistic framework for developing targeted antifibrotic therapies, including hepatocyte‐directed ...
Eui Jung Jung, Xiaobo Wang
wiley   +1 more source

GSK3 Inhibition During Annelid Head Regeneration Results in a Hyper‐Proliferative Blastema and Impaired Differentiation

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
A whole‐body regenerative annelid was treated with a GSK3 inhibitor. While posterior regeneration was mostly normal, GSK3 inhibition prevented differentiation of anterior‐specific structures and instead produced a persistent, oversized, hyper‐proliferative blastema. This suggests that GSK3 promotes anterior identity and halts proliferation during axial
James D. Nowotny, Eduardo E. Zattara, Maria Balarezo, Kevin G. Nyberg, Kenna M. Costello, Alexandra E. Bely   +5 more
wiley   +1 more source

Gezielte Smoothened-Inhibierung im Hedgehog-Signalweg durch PF-04449913 in der akuten myeloischen Leukämie [PDF]

, 2014
Die akute myeloische Leukämie (AML) macht einen Großteil der hämatologischen Neoplasien aus. Ihre Standardtherapie hat sich in den vergangenen Jahren wenig weiterentwickelt, sodass die Prognose weiterhin unbefriedigend ist.
Seyfert, Patrizia
core  

Prevention of Early Onset of Breast Cancer With Ashwagandha

Molecular Carcinogenesis, EarlyView.
ABSTRACT Prevention of breast cancer is feasible because many risk factors for this malignancy are known (e.g., family history, reproductive factors, etc.). Medicinal plants and/or their bioactive phytochemicals are attractive for the prevention of early onset of breast cancer due to their generally favorable safety profile.
Eun‐Ryeong Hahm, Su‐Hyeong Kim, Shivendra V. Singh   +2 more
wiley   +1 more source