Results 131 to 140 of about 718,149 (279)

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source

Hedgehog signaling is involved in acquired resistance against KRASG12C inhibitors in lung cancer cells

Although KRASG12C inhibitors have shown promising activity in lung adenocarcinomas harboring KRASG12C, acquired resistance to these therapies eventually occurs in most patients.
이채영
core  

Progress in bone tissue engineering biomaterials: Development, challenges, and prospects

VIEW, EarlyView.
Scheme 1 Application of biomaterials in immunomodulation during bone tissue engineering. Abstract Bone defect repair remains a major clinical challenge in orthopedics. Over 2 million cases caused by trauma, tumors, and other factors occur annually, with large‐scale defects posing a particular bottleneck due to limited self‐healing capacity.
Yuanbin Zhang, Junlei Chai, Quanwei Ding, Luping Liu, Kejie Zhang, Jie Lin, Jianhua Zhang, Youju Huang   +7 more
wiley   +1 more source

Hedgehog Signaling: Networking to Nurture a Promalignant Tumor Microenvironment

, 2011
In addition to its role in embryonic development, the Hedgehog pathway has been shown to be an active participant in cancer development, progression, and metastasis.
Rajeev S. Samant, Lalita A. Shevde, Lillianne G. Harris   +2 more
core   +1 more source

Does the Rule of Law Require the Separation of Powers?

The Modern Law Review, EarlyView.
The separation of powers is an enigmatic political ideal, particularly in the context of the modern administrative state, in which administrative officials routinely perform a combination of legislative, judicial, and executive functions. In this article we reexamine this ideal by interrogating Adrian Vermeule's provocative claim that the separation of
Dimitrios Kyritsis, Matthew Lewans
wiley   +1 more source

Hedgehog Inhibitors Suppress Osteoclastogenesis in In Vitro Cultures, and Deletion of Smo in Macrophage/Osteoclast Lineage Prevents Age-Related Bone Loss. [PDF]

Int J Mol Sci, 2020
Kohara Y, Haraguchi R, Kitazawa R, Imai Y, Kitazawa S.   +4 more
europepmc   +1 more source

Multi‐Omics Analysis Reveals Coordinated Adaptations in Genes, Metabolism, and Gut Microbiota Underpinning Herbivory in Lordiphosa Flies

Integrative Zoology, EarlyView.
Multi‐omics analysis reveals that herbivorous adaptation in Lordiphosa flies arises from coordinated interactions across the genome, transcriptome, and gut microbiota: genomic expansions of detoxification (e.g., cytochrome P450s) and carbohydrate metabolism gene families, transcriptomic upregulation of energy pathways like lipid oxidation and ...
Run Guo, Jianjun Gao, Caixian Zhang, Zhiheng Chang, Yanbo Sun   +4 more
wiley   +1 more source

Notch and Hedgehog Signalling Axis Drive Senescence in HER2-Positive Breast Cancer Resistant to Trastuzumab

European Journal of Biology
Objective: Cellular senescence halts the proliferation of damaged or preneoplastic cells, playing a vital role in cancer control. In HER2-positive breast cancer, resistance to trastuzumab, a HER2-targeted monoclonal antibody, remains a significant ...
Asiye Büşra Boz Er, İdris Er
doaj   +1 more source

Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined Treatments with Hedgehog Inhibitors in Advanced Basal Cell Carcinoma. [PDF]

Biomedicines, 2020
Cosio T, Di Prete M, Campione E.
europepmc   +1 more source

Quantitative Immunoblotting of Endogenous Hedgehog Pathway Components

, 2015
Quantitative analysis and modeling of signaling pathway components can reveal important information about the dynamics of that system, including the relative stoichiometries and affinities between the individual signaling components, as well as rate ...
Robbins, David J, Farzan, Shohreh F, Shohreh F. Farzan, David J. Robbins   +3 more
core   +1 more source