Results 121 to 130 of about 718,149 (279)

Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway.

, 2009
Ortho-biphenyl carboxamides, originally prepared as inhibitors of microsomal triglyceride transfer protein (MTP) have been identified as novel inhibitors of the Hedgehog signaling pathway.
Geisser, Adrian, Sun, Yingchuan, Dasilva, Jennifer, Kelleher Iii, Joseph, Bourret, Aaron, Ramamurthy, Arun, Jain, Rishi, Peukert, Stefan, Zhang, Rui, Carlson, Adam   +9 more
core   +1 more source

Protein Glutamylation: From Cytoskeleton to Signaling

Med Research, EarlyView.
Tubulin glutamylation, γ‐glutamylation, and nontubulin glutamylation are distinct yet interconnected post‐translational modifications that regulate diverse physiological and pathological processes, including cytoskeletal organization, cell cycle progression, immunity, metabolism, and disease development.
Jiayuan Chen, Yi Yuan, Qingquan Yu, Xinyue Wang, Hui Wang   +4 more
wiley   +1 more source

The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors

Medicinal Research Reviews, EarlyView.
ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti, Camilla Tavani, Elena Somenza, Nicolas Tassone, Antonio d'Amati, Marta Turati, Roberto Ronca   +6 more
wiley   +1 more source

TARGETING HEDGEHOG PATHWAY SIGNALING IN RENAL CANCER CELLS LINES: A CANCER STEM CELL PERSPECTIVE

, 2013
The purpose of this study is to confirm the presence and expression of Hedgehog Pathway genes and to determine the effects of inhibition of the Hedgehog Pathway on renal cancer cells. RNA from the chosen renal cancer cell lines will be isolated, and real
Borjas, Yves A.
core   +1 more source

Mechanisms and impacts of future plant invasions: research agendas and management needs under disruptive social‐ecological change scenarios

Oikos, EarlyView.
No‐analogue futures are characteristic of the Anthropocene, but how global change, and societies' responses, will affect plant invasions remains unclear. Conducting research now to address future needs is crucial for guiding invasion management and policy.
Jennifer L. Bufford, Angela J. Brandt, Rowan Sprague, Christopher E. Buddenhagen, Richard P. Duncan, Nichola Harcourt, Philip E. Hulme, Hao Ran Lai, Kate G. McAlpine, Chris McGrannachan, Fiona J. Thomson, Vincent van Uitregt, Duane A. Peltzer   +12 more
wiley   +1 more source

Treatment of progressive locally advanced and metastatic basal cell carcinoma after two lines of treatment with hedgehog inhibitors and anti-PD1. the role of sonidegib rechallenge

Treatment of progressive locally advanced and metastatic basal cell carcinoma after two lines of treatment with hedgehog inhibitors and anti-PD1: The role of sonidegib ...
Guida, S, Di Lella, G, Guida S., Ambrosio L., Zalaudek, I, Conforti C., Retrosi C., Pellacani, G, Giuffrida, R, Longo, C, Zalaudek I., Agozzino M., Di Lella G., di Meo N., Cantisani, C, Agozzino, M, Ambrosio, L, Conforti, C, Giuffrida R., Retrosi, C, Longo C., Lembo, S, Pellacani G., di Meo, N, Lembo S., Cantisani C., Cantisani, C., di Meo, N., Ambrosio, L., Di Lella, G., Longo, C., Pellacani, G., Zalaudek, I., Agozzino, M., Retrosi, C., Guida, S., Lembo, S., Conforti, C., Giuffrida, R.   +38 more
core   +1 more source

Molecular Basis for Uracil‐DNA‐Glycosylase to Identify DNA Damage in the Nucleosome

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The DNA base‐excision repair (BER) pathway is initiated by a glycosylase, such as uracil‐DNA‐glycosylase (UDG), which identifies and removes a wrong base incorporated in the DNA sequence. The very early steps in the identification of the DNA damage are crucial to the correct initiation of the repair chain, and become even more complex when ...
Safwen Ghediri, Ralf Blossey, Fabrizio Cleri   +2 more
wiley   +1 more source

The role of a multidisciplinary approach in non-melanoma skin cancer management

Dermatology Reports
A multidisciplinary team (MDT) is fundamental for properly managing non-melanoma skin cancer (NMSC). Surgery is the first treatment choice for early-stage disease; however, in cases with a high risk of recurrence or when demolitive approaches would not ...
Francesca Lussana, Nerina Denaro, Emanuela Passoni, Giulia Murgia, Valentina Benzecry, Paolo Bortoluzzi, Carolina Cauchi, Andrea Vavassori, Roberta Lazzari, Giada Anna Beltramini, Cinzia Solinas, Ornella Garrone, Gianluca Nazzaro, Angelo Valerio Marzano   +13 more
doaj   +1 more source

Studies Directed toward the Elucidation of the Pharmacophore of Steroid-Based Sonic Hedgehog Signaling Inhibitors

, 2016
Previous work from our laboratory has established that the readily available steroid-based analog 2 of cyclopamine 1 is, like 1, a highly potent inhibitor of Hedgehog signaling.
Valérie Baubet (2162806), André K. Isaacs (2162800), Nadia Dahmane (2162803), Jeffrey D. Winkler (803032), Chaomei Xiang (386859)   +4 more
core   +1 more source

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source