Results 191 to 200 of about 31,386 (239)

Itraconazole in the Treatment of Aberrantly Active Hedgehog and/or PI3K Recurrent Ovarian Cancer. [PDF]

Cancers (Basel)
Hendrikse CSE, Voeten N, van der Ploeg P, Smedts HPM, Westgeest HM, Bosch S, Lalisang RI, Vriens BEPJ, Thijs AMJ, Lambrechts S, Bekkers RLM, Piek JMJ.   +11 more
europepmc   +1 more source

Advanced Basal Cell Carcinoma in a Geriatric Patient: A Case Report and Ethical Considerations. [PDF]

Cureus
Velázquez Arenas L, Garay Enriquez S, Gómez Guerra D.   +2 more
europepmc   +1 more source

Case Report: PTCH1 splice-site mutation and sonidegib treatment in Gorlin-Goltz syndrome: clinical insights from a family case study. [PDF]

Front Med (Lausanne)
Liu L, Du H, Wang N, Lv S, Yu C, Deng L.
europepmc   +1 more source

CALCITRIOL - A POTENT HEDGEHOG SIGNALING INHIBITOR

, 2018
openaire   +1 more source

Hedgehog signaling inhibitors in solid and hematological cancers [PDF]

Cancer Treatment Reviews, 2019
The hedgehog signaling pathway is normally tightly regulated. Mutations in hedgehog pathway components may lead to abnormal activation. Aberrantly activated hedgehog signaling plays a major role in the development of solid and hematological cancer. In recent years, inhibitors have been developed that attenuate hedgehog signaling; 2 have been approved ...
Jorge E Cortes, Ralf Gutzmer, Mark W Kieran   +2 more
exaly   +3 more sources

Hedgehog Signaling Inhibitors as Anti-Cancer Agents in Osteosarcoma [PDF]

Cancers, 2015
Osteosarcoma is a rare type of cancer associated with a poor clinical outcome. Even though the pathologic characteristics of OS are well established, much remains to be understood, particularly at the molecular signaling level. The molecular mechanisms of osteosarcoma progression and metastases have not yet been fully elucidated and several ...
Ram Mohan Ram Kumar, Bruno Fuchs, Fuchs Bruno   +2 more
exaly   +4 more sources

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Potent Inhibitors of the Hedgehog Signaling Pathway

Journal of Medicinal Chemistry, 2008
A small family of phenyl quinazolinone ureas is reported as potent modulators of Hedgehog protein function. Preliminary SAR studies of the urea substituent led to a nanomolar Hedgehog antagonist.
Shirley A, Brunton, John H A, Stibbard, Lee L, Rubin, Lawrence I, Kruse, Oivin M, Guicherit, Edward A, Boyd, Steven, Price   +6 more
openaire   +2 more sources

Hedgehog inhibitors: a patent review (2013 – present)

Expert Opinion on Therapeutic Patents, 2015
The hedgehog (Hh) signaling pathway is an important signaling pathway, playing a critical role in regulation of cell growth, development, metastasis and angiogenesis. Aberrant activation of this pathway has been linked to the development of several human tumor types, which makes it an attractive target for cancer treatment.
Minhang Xin
exaly   +3 more sources

Hedgehog inhibitors from Withania somnifera

Bioorganic & Medicinal Chemistry Letters, 2015
The hedgehog (Hh) signaling pathway performs an important role in embryonic development and in cellular proliferation and differentiation. However, aberrant activation of the Hh signaling pathway is associated with tumorigenesis. Hh signal inhibition was evaluated using a cell-based assay system that targets GLI1-mediated transcription. Activity-guided
Tatsuro, Yoneyama, Midori A, Arai, Samir K, Sadhu, Firoj, Ahmed, Masami, Ishibashi   +4 more
openaire   +2 more sources