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Hedgehog pathway inhibitors in eyelid tumors
Acta OphthalmologicaAims/Purpose: Basal cell carcinoma (BCC) is the most common type of tumor worldwide. Although it has a low capacity for systemic spread, it exhibits a high rate of local invasion. The most frequently affected areas are the face and neck. So far, the most widely used treatment has been surgery in its various forms: excision‐electrodesiccation‐curettage,
Elisa Funes +9 more
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From Hedgehog Facilitator to Wnt Inhibitor
Science's STKE, 2005A regulatory protein that controls Wnt signaling in humans appears to have switched jobs during the course of evolution. Two papers reporting studies in flies suggest that Wnt inhibitory factor (WIF) first had an opposite role in regulation of Hedgehog signaling.
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Small-Molecule Inhibitors of the Hedgehog Pathway
2011The causal link between uncontrolled Hedgehog (Hh) pathway activation and oncogenesis has inspired the development of small-molecule inhibitors of this developmental signaling pathway. In this chapter, we discuss how a cyclopia-inducing natural product isolated in the 1950s has engendered a pharmacopoeia of compounds that block Hh target gene ...
Ari J. Firestone, James K. Chen
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Oral Hedgehog-Pathway Inhibitors for Basal-Cell Carcinoma
New England Journal of Medicine, 2012Basal-cell carcinoma of the skin is the most common cancer worldwide, and its prevalence is increasing, accounting for 80% of nonmelanoma skin cancers.1 In 2006, more than 2.1 million new cases of nonmelanoma skin cancer were treated in the United States.2 Basal-cell carcinoma has many clinical subtypes and can progress to an advanced state in which ...
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Hedgehog pathway inhibitors come of age
British Journal of Dermatology, 2019openaire +2 more sources
Smoothened Inhibitors in Sonic Hedgehog Subgroup Medulloblastoma
Journal of Clinical Oncology, 2015Katherine J, Ransohoff +2 more
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The Hedgehog pathway and its inhibitors: Emerging therapeutic approaches for basal cell carcinoma
Drug Discovery Today, 2022Rupesh Jain +2 more
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Design and Synthesis of New Withaferin A Inspired Hedgehog Pathway Inhibitors
Chemistry - A European Journal, 2021Mattia Mori +2 more
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