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RAS signaling and remodeling of the immune microenvironment in pancreatic ductal adenocarcinoma: implications of emerging RAS-targeted therapy. [PDF]
Front Cell Dev BiolMeng D, Zhang C.
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Oral Acitretin Combined with Topical 0.1% Tretinoin Cream for Facial Basal Cell Carcinoma in an Elderly Patient: A Case Report. [PDF]
BiologicsShu Z +5 more
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Hedgehog Inhibitors From Withania somnifera
Bioorganic and Medicinal Chemistry Letters, 2015The hedgehog (Hh) signaling pathway performs an important role in embryonic development and in cellular proliferation and differentiation. However, aberrant activation of the Hh signaling pathway is associated with tumorigenesis. Hh signal inhibition was evaluated using a cell-based assay system that targets GLI1-mediated transcription. Activity-guided
Masami Ishibashi +2 more
exaly +3 more sources
Potent Inhibitors of the Hedgehog Signaling Pathway
Journal of Medicinal Chemistry, 2008A small family of phenyl quinazolinone ureas is reported as potent modulators of Hedgehog protein function. Preliminary SAR studies of the urea substituent led to a nanomolar Hedgehog antagonist.
Shirley A, Brunton +6 more
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Hedgehog Signaling Inhibitors in Solid and Hematological Cancers [PDF]
Cancer Treatment Reviews, 2019 The hedgehog signaling pathway is normally tightly regulated. Mutations in hedgehog pathway components may lead to abnormal activation. Aberrantly activated hedgehog signaling plays a major role in the development of solid and hematological cancer. In recent years, inhibitors have been developed that attenuate hedgehog signaling; 2 have been approved ...
Ralf Gutzmer +2 more
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