Results 101 to 110 of about 2,340,031 (328)
The Hedgehog Signaling Pathway in the Mouse Ovary1 [PDF]
Biology of Reproduction, 2007 The hedgehog (HH) signaling pathway plays an essential role in the Drosophila ovary, regulating cell proliferation and differentiation, but a role in the mammalian ovary has not been defined. Expression of components of the HH pathway in the mouse ovary and effects of altering HH signaling in vitro were determined.
Susan M. Quirk +4 more
openaire +3 more sources
Advanced Science, EarlyView.3D‐cultured renal cancer cells exhibit stem‐like phenotypes and are more efficient in generating bone metastases. Vitamin C treatment can suppress the development of bone metastasis. Single‐cell transcriptomic analysis reveals that vitamin C inhibits metastasis by inducing tumor cell cycle arrest, suppressing osteoclast differentiation, and reducing ...
Jianye Zhang +17 more
wiley +1 more source
Super-enhancer hijacking drives ectopic expression of hedgehog pathway ligands in meningiomas
Nature Communications, 2023 Hedgehog signaling mediates embryologic development of the central nervous system and other tissues and is frequently hijacked by neoplasia to facilitate uncontrolled cellular proliferation.
Mark W. Youngblood +36 more
doaj +1 more source
Hedgehogs of Hausdorff dimension one [PDF]
arXiv, 2009 We present a construction of hedgehogs for holomorphic maps with an indifferent fixed point. We construct, for a family of commuting non-linearisable maps, a common hedgehog of Hausdorff dimension 1, the minimum possible.
arxiv
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance The ciliary membrane-localized transmembrane Hedgehog receptor Patched1 suppresses the ciliary translocation of the transmembrane oncoprotein Smoothened and consequently Hedgehog pathway activation, but the mechanism underlying this process ...
Boyan Zhang +11 more
semanticscholar +1 more source
Evolutionary Divergence in the Hedgehog Pathway
Developmental Cell, 2011 I like this paper because the findings that it reports took me completely by surprise—and serve as a constant reminder of the fallibility of my own scientific logic! A few years earlier, Rune Toftgård had invited me to give a talk at the Karolinska Institute about our analysis of the Hedgehog (HH) signaling pathway in Drosophila.
openaire +2 more sources
Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine
Advanced Science, EarlyView.Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang +4 more
wiley +1 more source
Combined cemiplimab and radiotherapy for advanced basal cell carcinoma: A case report
SAGE Open Medical Case Reports, 2023 Advanced basal cell carcinoma may be treated with systemic therapies such as hedgehog pathway inhibitors or programmed cell death protein 1 inhibitors, namely cemiplimab.
Sidra Sarfaraz +2 more
doaj +1 more source
Smooth Combs Inside Hedgehogs [PDF]
arXiv, 2009 We use techniques of tube-log Riemann surfaces due to R.Perez-Marco to construct a hedgehog containing smooth $C^{\infty}$ combs. The hedgehog is a common hedgehog for a family of commuting non-linearisable holomorphic maps with a common indifferent fixed point. The comb is made up of smooth curves, and is transversally bi-H\"older regular.
arxiv
Advanced Science, EarlyView.Abstract Liver cancer stem cells (CSCs) account for tumor initiation, heterogeneity and therapy resistance. However, the role of small nucleolar RNAs (snoRNAs) in the regulation of liver CSCs remains largely unclear. Here, this work identifies a conserved H/ACA box snoRNA SNORA74A which is highly expressed in liver CSCs.
Ziheng Zhou +12 more
wiley +1 more source