Results 111 to 120 of about 2,340,031 (328)
Fish species lifespan prediction from promoter cytosine‐phosphate‐guanine density
Molecular Ecology Resources, EarlyView., 2023 Abstract Lifespan is a key attribute of a species' life cycle and varies extensively among major lineages of animals. In fish, lifespan varies by several orders of magnitude, with reported values ranging from less than 1 year to approximately 400 years.
Alyssa M. Budd +3 more
wiley +1 more source
The Radial-Hedgehog Solution in Landau--de Gennes' theory [PDF]
arXiv, 2010 We study the radial-hedgehog solution in a three-dimensional spherical droplet, with homeotropic boundary conditions, within the Landau-de Gennes theory for nematic liquid crystals. The radial-hedgehog solution is a candidate for a globally stable configuration in this model framework and is also a prototype configuration for studying isolated point ...
arxiv
Proteostasis in the Hedgehog signaling pathway
Seminars in Cell & Developmental Biology, 2019 The Hedgehog (Hh) signaling pathway is crucial for the development of vertebrate and invertebrate animals alike. Hh ligand binds its receptor Patched (Ptc), allowing the activation of the obligate signal transducer Smoothened (Smo). The levels and localizations of both Ptc and Smo are regulated by ubiquitination, and Smo is under additional regulation ...
openaire +3 more sources
The Hedgehog signalling pathway regulates autophagy [PDF]
Nature Communications, 2012 Autophagy is a highly conserved degradative process that removes damaged or unnecessary proteins and organelles, and recycles cytoplasmic contents during starvation. Autophagy is essential in physiological processes such as embryonic development but how autophagy is regulated by canonical developmental pathways is unclear.
Jimenez-Sanchez, Maria +5 more
openaire +4 more sources
Worth the Effort: Lessons for Discovery and Care From an Unusual Case of Gorlin Syndrome
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Gorlin‐Goltz Syndrome (GGS) is a rare autosomal dominant genetic disorder encompassing a diverse range of clinical manifestations, including congenital anomalies and predisposition to cancer. Pathogenic variants in PTCH1 and SUFU account for up to 79% and 6% of cases, respectively. Currently, an estimated 15%–27% of individuals with a clinical
V. Taliercio +13 more
wiley +1 more source
A tale of three hedgehogs [PDF]
arXiv, 2017 In this work we study three topologies defined over the same set: the hedgehog. As the name suggests, the hedgehog can be described as a set of spines identified at a single point. Among others, we give a proof of the Kowalsky hedgehog theorem, which asserts that every metrizable space is embeddable into a countable cartesian power of the metric ...
arxiv
Sonic hedgehog pathway expression in non-small cell lung cancer
Therapeutic Advances in Medical Oncology, 2012 Objective: Activation of the hedgehog pathway is an important signaling mechanism crucial in embryogenesis and has strong links to carcinogenesis. This study investigates the expression of the Sonic hedgehog pathway molecules in non-small cell lung ...
Malvi Savani +3 more
doaj +1 more source
Inhibition of hedgehog pathway reveals the regulatory role of SMO in gastric cancer cells
Tumor Biology, 2017 Previous studies report aberrant activation of the hedgehog signaling pathway in the progression of various cancers. This study aimed to investigate the expressions of smoothened and downstream glioma-associated oncogene homology-1 in gastric cancer and ...
Zixin Yang +6 more
doaj +1 more source
Stability of the melting hedgehog in the Landau-de Gennes theory of nematic liquid crystals [PDF]
, 2014 We investigate stability properties of the radially symmetric solution corresponding to the vortex defect (so called "melting hedgehog") in the framework of the Landau - de Gennes model of nematic liquid crystals. We prove local stability of the melting hedgehog under arbitrary $Q$-tensor valued perturbations in the temperature regime near the critical
arxiv +1 more source
Cellular Physiology and Biochemistry, 2016 Background/Aims: Lipid accumulation, inflammatory responses and oxidative stress have been implicated in the pathology of alcoholic liver disease (ALD). Targeting inhibition of these features may provide a promising therapeutic strategy for ALD. Baicalin,
Huifen Wang +4 more
semanticscholar +1 more source