Results 111 to 120 of about 49,844 (160)
Tuning the Hedgehog pathway [PDF]
Nature Reviews Molecular Cell Biology, 2012 openaire +1 more source
Vismodegib and Hedgehog signalling pathway
, 2015 Sonic Hedgehog signaling pathway was discovered in the nineties, especially for its implication in the development of the embryo, which led to further investigations of its molecular biology. It promotes cell division and proliferation, and its role in oncogenesis was later described, especially in the basal cell carcinoma. The development of molecules
Miranda Chacón, Zaray +1 more
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A recurrent mosaic mutation in SMO, encoding the hedgehog signal transducer smoothened, is the major cause of Curry-Jones syndrome [PDF]
, 2016 et al,, Grange, Dorothy K
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Science's STKE, 2007
The Hedgehog (Hh) signaling pathway is essential for development and tissue homeostasis in metazoans. Probably as a result of its potent influence on cell-fate outcomes, the Hh pathway when corrupted results in malformations and diseases such as cancer. Many of the pathway components that contribute to Hh-mediated signal transduction are presented.
Leni, Jacob, Lawrence, Lum
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The Hedgehog (Hh) signaling pathway is essential for development and tissue homeostasis in metazoans. Probably as a result of its potent influence on cell-fate outcomes, the Hh pathway when corrupted results in malformations and diseases such as cancer. Many of the pathway components that contribute to Hh-mediated signal transduction are presented.
Leni, Jacob, Lawrence, Lum
openaire +2 more sources
Clinical Pharmacology & Therapeutics, 2010
Since the observation nearly 50 years ago of cyclopic newborn lambs borne by ewes grazing on California corn lily, an explosion of discovery has ensued. The Hedgehog (HH) signaling pathway is perhaps one of the most exciting targets in cancer research today.
G J, Weiss, D D, Von Hoff
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Since the observation nearly 50 years ago of cyclopic newborn lambs borne by ewes grazing on California corn lily, an explosion of discovery has ensued. The Hedgehog (HH) signaling pathway is perhaps one of the most exciting targets in cancer research today.
G J, Weiss, D D, Von Hoff
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Small molecule Hedgehog pathway antagonists
Organic & Biomolecular Chemistry, 2017Leveraging our quinolone-1-(2H)-one based Hedgehog signalling pathway (HSP) inhibitors we have developed two new classes of HSP inhibitors based on: l-tryptophan and benzo[1,3]dioxol-5-ylmethyl-[2-(1H-indol-3-yl)-ethyl]-amine.
Trieu N. Trinh +6 more
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Hedgehog-GLI Pathway in Medulloblastoma
Journal of Clinical Oncology, 2012Medulloblastoma (MB), the most common malignant brain tumor in children, arises in the cerebellum. Aberrant activation of the sonic hedgehog (SHH) pathway has been unambiguously tied to the etiology of one subtype of the disease. Although the majority of tumors arise through somatic mutations, familial predisposition to MB is well known to occur in ...
Tenley C, Archer +2 more
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