Results 151 to 160 of about 2,340,031 (328)

Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein [PDF]

, 2000
Philip W. Ingham, Sverker Nystedt, Yoshiro Nakano, William O. Brown, D. Stark, Marcel van den Heuvel, Amanda Taylor   +6 more
openalex   +1 more source

Nestin Mediates Hedgehog Pathway Tumorigenesis.

Cancer Research, 2016
The intermediate filament protein Nestin serves as a biomarker for stem cells and has been used to identify subsets of cancer stem-like cells. However, the mechanistic contributions of Nestin to cancer pathogenesis are not understood.
Peng Li, Eric H. Lee, Fang Du, R. Gordon, Larra W. Yuelling, Yongqiang Liu, Jessica M. Y. Ng, Hao F. Zhang, Jinhua Wu, A. Korshunov, S. Pfister, T. Curran, Zeng-jie Yang   +12 more
semanticscholar   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Hedgehog/Gli2 signaling triggers cell proliferation and metastasis via EMT and wnt/β-catenin pathways in oral squamous cell carcinoma

Heliyon
Background: Oral squamous cell carcinoma (OSCC) is the most lethal oral malignant tumor, however, clinical outcomes remain unsatisfactory. The Hedgehog/Gli2 pathway plays a pivotal role in tumor progression, yet the regulatory mechanism governing its ...
Xiaotang Wang, Xiaona Song, Jiping Gao, Guoqiang Xu, Xiaoru Yan, Junting Yang, Yiyan Yang, Guohua Song   +7 more
doaj  

Bone Anabolic Effects of Sonic/Indian Hedgehog Are Mediated By BMP-2/4-Dependent Pathways in the Neonatal Rat Metatarsal Model [PDF]

, 2001
Venkatesh Krishnan, Yanfei Li, J. M. Moseley, Andrew G. Geiser, Sylvie Friant, Charles A. Frolik   +5 more
openalex   +1 more source

Molecular subtyping and precision therapy for esophageal cancer

Interdisciplinary Medicine, EarlyView.
The molecular typing of esophageal cancer based on genome, transcriptome, proteome, and multi‐omics revealed various molecular features and provided potential targets for the precision therapy. Recent trials have shown that immunotherapy or molecular targeted therapy plus chemoradiotherapy can improve overall survival and progression‐free survival in ...
Guangkun Pei, Zhuoran Liang, Bianli Gu, Linlin Shi, Ze‐Xian Liu, Shegan Gao   +5 more
wiley   +1 more source

Chinese herbal medicine‐derived extracellular vesicle‐like particles: Therapeutic potential and future research approaches

Interdisciplinary Medicine, EarlyView.
This article evaluates the therapeutic potential of extracellular vesicle‐like particles derived from Chinese herbal medicine (CHM‐EVLP) for a range of diseases. It underscores the significance of traditional Chinese medicine in the development of innovative formulations.
Ying‐qi Cao, Zheng‐ting Wu, Qi You, Yuan‐yuan Xia, Qing Zhao, Carine de Marcos Lousa, Ke‐wei Zhao   +6 more
wiley   +1 more source

The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway. [PDF]

, 2002
Barbara Stecca, Ariel Ruiz i Altaba
openalex   +1 more source

Embryogenesis in Myrmicine Ants Combines Features of Short Germ‐Band Development With a Progressive Mode of Segmentation

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Different insect species exhibit remarkable diversity in the developmental trajectories from fertilized eggs to hatching larvae. For three myrmicine ant species, we observe a novel combination of a developmental features: small embryonic primordia, a mode of embryogenesis termed short/intermediate germ‐band development, and progressive establishment of
Chi‐Chun Fang, Arjuna Rajakumar, Andrew Kenny, Ulrich G. Mueller, Ehab Abouheif, David Stein   +5 more
wiley   +1 more source

The middle hedgehog of a planar convex body [PDF]

arXiv, 2016
A convexity point of a convex body is a point with the property that the union of the body and its reflection in the point is convex. It is proved that in the plane a typical convex body (in the sense of Baire category) has infinitely many convexity points.
arxiv