Results 11 to 20 of about 2,340,031 (328)
The emerging roles of phosphatases in Hedgehog pathway [PDF]
Cell Communication and Signaling, 2017 Hedgehog signaling is evolutionarily conserved and plays a pivotal role in cell fate determination, embryonic development, and tissue renewal. As aberrant Hedgehog signaling is tightly associated with a broad range of human diseases, its activities must be precisely controlled.
Long Zhao +4 more
doaj +7 more sources
The Role of Hedgehog Pathway in Female Cancers
Journal of Cancer Science and Clinical Therapeutics, 2020 The hedgehog pathway (HH) is one of the key regulators involved in many biological events. Malfunction of this pathway is associated with a variety of diseases including several types of cancers.We collected data from public databases and conducted a comprehensive search linking the HH pathway with female cancers.
Qiwei Yang +3 more
openaire +4 more sources
Cell Death and Disease, 2017 mTORC2 is aberrantly activated in cancer and therefore is considered to be an important therapeutic target. The hedgehog pathway, which is also often hyperactivated, regulates transcription of several genes associated with angiogenesis, metastasis ...
Samarpan Maiti +3 more
doaj +2 more sources
Prostate cancer and Hedgehog signalling pathway [PDF]
Clinical and Translational Oncology, 2007 The Hedgehog (Hh) family of intercellular signalling proteins have come to be recognised as key mediators in many fundamental processes in embryonic development. Their activities are central to the growth, patterning and morphogenesis of many different regions within the bodies of vertebrates.
Antón-Aparicio, Luis M. +6 more
openaire +4 more sources
The role of kinases in the Hedgehog signalling pathway [PDF]
EMBO reports, 2008 The Hedgehog (Hh) signalling pathway has a crucial role in several developmental processes and is aberrantly activated in a variety of cancers. In Drosophila, many of the canonical Hh pathway components are phosphorylated, yet the precise role of these phosphorylation events in the regulation of Hh signal transduction is unclear.
Aikin, Reid A +2 more
openaire +5 more sources
Implication of the Hedgehog pathway in hepatocellular carcinoma
World Journal of Gastroenterology, 2017 The prognosis for patients who are diagnosed with advanced stage hepatocellular carcinoma (HCC) is poor because there are few treatment options. Recent research has focused on the identification of novel molecular entities that can be targeted to inhibit oncogenic signals that are involved in the carcinogenesis, proliferation and progression of HCC ...
Della Corte CM +8 more
openaire +4 more sources
Hedgehog Pathway Inhibitors as Targeted Cancer Therapy and Strategies to Overcome Drug Resistance
International Journal of Molecular Sciences, 2022 Hedgehog (Hh) signaling is a highly conserved pathway that plays a vital role during embryonic development. Recently, uncontrolled activation of this pathway has been demonstrated in various types of cancer.
Ngoc Minh Nguyen, Jungsook Cho
semanticscholar +1 more source
Plexins promote Hedgehog signaling through their cytoplasmic GAP activity
eLife, 2022 Hedgehog signaling controls tissue patterning during embryonic and postnatal development and continues to play important roles throughout life. Characterizing the full complement of Hedgehog pathway components is essential to understanding its wide ...
Justine M Pinskey +7 more
doaj +1 more source
Cell Death and Disease, 2021 Long noncoding RNAs (lncRNAs) play crucial roles in regulating a variety of biological processes in lung adenocarcinoma (LUAD). In our study, we mainly explored the functional roles of a novel lncRNA long intergenic non-protein coding RNA 1426 (LINC01426)
Xiaoli Liu +6 more
semanticscholar +1 more source