Results 21 to 30 of about 49,844 (160)
Crosstalk of Hedgehog and mTORC1 Pathways [PDF]
Cells, 2020 Hedgehog (Hh) signaling and mTOR signaling, essential for embryonic development and cellular metabolism, are both coordinated by the primary cilium. Observations from cancer cells strongly indicate crosstalk between Hh and mTOR signaling. This hypothesis is supported by several studies: Evidence points to a TGFβ-mediated crosstalk; Increased PI3K/AKT ...
Lasse Jonsgaard Larsen +1 more
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Hedgehog Signaling: An Achilles’ Heel in Cancer
Translational Oncology, 2019 Hedgehog signaling pathway originally identified in the fruit fly Drosophila is an evolutionarily conserved signaling mechanism with crucial roles in embryogenesis, growth and patterning. It exerts its biological effect through a signaling mechanism that
Madiha Niyaz +2 more
doaj +1 more source
Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma. [PDF]
, 2019 Dysregulation of the seven-transmembrane (7TM) receptor Smoothened (SMO) and other components of the Hedgehog (Hh) signaling pathway contributes to the development of cancers including basal cell carcinoma (BCC) and medulloblastoma (MB).
Abagyan, Ruben +7 more
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Hedgehog Signaling and Embryonic Craniofacial Disorders
Journal of Developmental Biology, 2019 Since its initial discovery in a Drosophila mutagenesis screen, the Hedgehog pathway has been revealed to be instrumental in the proper development of the vertebrate face. Vertebrates possess three hedgehog paralogs: Sonic hedgehog (Shh), Indian hedgehog
John Abramyan
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The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo
Communications Biology, 2021 By modulating the activation state of the Hedgehog pathway, de la Rocha-Muñoz et al demonstrate that Hedgehog signaling controls the expression and transport activity of the neuronal glycine transporter GlyT2.
Andrés de la Rocha-Muñoz +8 more
doaj +1 more source
Localized JNK signaling regulates organ size during development. [PDF]
, 2016 A fundamental question of biology is what determines organ size. Despite demonstrations that factors within organs determine their sizes, intrinsic size control mechanisms remain elusive.
Beachy, Philip A +5 more
core +3 more sources
Hedgehog Pathway Blockade Inhibits Melanoma Cell Growth in Vitro and in Vivo
Pharmaceuticals, 2013 Previous reports have demonstrated a role for hedgehog signaling in melanoma progression, prompting us to explore the therapeutic benefit of targeting this pathway in melanoma.
Eva Hernando +10 more
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Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold [PDF]
, 2018 Aberrant activation of the Hedgehog (Hh) pathway is responsible for the onset and progression of several malignancies. Small molecules able to block the pathway at the upstream receptor Smoothened (Smo) or the downstream effector Gli1 have thus emerged ...
Bruno Botta +12 more
core +2 more sources
Hedgehog Pathway Inhibitors against Tumor Microenvironment [PDF]
Cells, 2021 Targeting the hedgehog (HH) pathway to treat aggressive cancers of the brain, breast, pancreas, and prostate has been ongoing for decades. Gli gene amplifications have been long discovered within malignant glioma patients, and since then, inhibitors against HH pathway-associated molecules have successfully reached the clinical stage where several of ...
Gampala, Silpa, Yang, Jer-Yen
openaire +4 more sources
Usability of serum hedgehog signalling proteins as biomarkers in canine mammary carcinomas
BMC Veterinary Research, 2023 Background The hedgehog signalling pathway has been implicated in tumourigenesis and progression of many tumour types. This pathway has recently emerged as a therapeutic target, and inhibitors of hedgehog signalling have gained considerable attention. In
Haein Koo, Sungin Lee, Wan Hee Kim
doaj +1 more source