Results 21 to 30 of about 2,340,031 (328)
The hedgehog pathway suppresses neuropathogenesis in CD4 T cell-driven inflammation.
Brain : a journal of neurology, 2021 The concerted actions of the CNS and the immune system are essential to coordinate the outcome of neuroinflammatory responses. Yet, the precise mechanisms involved in this crosstalk and their contribution to the pathophysiology of neuroinflammatory ...
Naïl Benallegue +12 more
semanticscholar +1 more source
The Role of the Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers
Cells, 2021 The hedgehog pathway, which plays a significant role in embryonic development and stem cell regulation, is activated in gastrointestinal cancers. Chemotherapy is widely used in cancer treatment.
Yabin Liang, Ling Yang, Jingwu Xie
semanticscholar +1 more source
Signaling in the primary cilium through the lens of the Hedgehog pathway
Wiley Interdisciplinary Reviews: Developmental Biology, 2020 Cilia are microtubule‐based, cell‐surface projections whose machinery is evolutionarily conserved. In vertebrates, cilia are observed on almost every cell type and are either motile or immotile.
E. Gigante, T. Caspary
semanticscholar +1 more source
Hedgehog Pathway Inhibitors: A New Therapeutic Class for the Treatment of Acute Myeloid Leukemia.
Blood Cancer Discovery, 2020 Targeting Hedgehog (Hh) pathway components, such as Smoothened (SMO), is a developing strategy for the treatment of acute myeloid leukemia (AML) and for overcoming relapsed/refractory forms of this disease.
C. Jamieson +3 more
semanticscholar +1 more source
The you gene encodes an EGF-CUB protein essential for Hedgehog signaling in zebrafish. [PDF]
PLoS Biology, 2005 Hedgehog signaling is required for many aspects of development in vertebrates and invertebrates. Misregulation of the Hedgehog pathway causes developmental abnormalities and has been implicated in certain types of cancer.
Ian G Woods, William S Talbot
doaj +1 more source
Nature Communications, 2023 Target deconvolution of small molecule hits from phenotypic screens presents a major challenge. Many screens have been conducted to find inhibitors for the Hedgehog signaling pathway – a developmental pathway with many implications in health and disease –
Meropi Bagka +8 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Precise manipulation of Hedgehog pathway activity holds great value for biological research and clinical applications, but pathway agonists amenable to engineering have been lacking.
Yunxiao Zhang +11 more
semanticscholar +1 more source
The role of Hedgehog and Notch signaling pathway in cancer
Molecular Biomedicine, 2022 Notch and Hedgehog signaling are involved in cancer biology and pathology, including the maintenance of tumor cell proliferation, cancer stem-like cells, and the tumor microenvironment.
Ruolan Xia +3 more
semanticscholar +1 more source
Topological transport of deconfined hedgehogs in magnets [PDF]
Phys. Rev. Lett. 125, 267201 (2020), 2020 We theoretically investigate the dynamics of magnetic hedgehogs, which are three-dimensional topological spin textures that exist in common magnets, focusing on their transport properties and connections to spintronics. We show that fictitious magnetic monopoles carried by hedgehog textures obey a topological conservation law, based on which a ...
arxiv +1 more source
Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway
Journal of Cell Biology, 2020 The Hedgehog pathway can be activated by cilia-associated sterol and oxysterol lipids that bind to Smoothened. Findakly et al. identify two enzymes near the ciliary base that activate the Hedgehog pathway, shedding light on how the lipid composition of ...
S. Findakly +12 more
semanticscholar +1 more source