Results 31 to 40 of about 2,340,031 (328)
Frontiers in Physiology, 2018 Hedgehog signaling pathway participates in a chain of necessary physiological activities and dysregulation of the hedgehog signaling has been implicated in birth defects and diseases.
Huijuan Li +4 more
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Tumor-Derived Suppressor of Fused Mutations Reveal Hedgehog Pathway Interactions. [PDF]
PLoS ONE, 2016 The Hedgehog pathway is a potent regulator of cellular growth and plays a central role in the development of many cancers including basal cell carcinoma (BCC).
Nicole M Urman +6 more
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Sonic Hedgehog activation is implicated in diosgenin-induced megakaryocytic differentiation of human erythroleukemia cells. [PDF]
PLoS ONE, 2014 Differentiation therapy is a means to treat cancer and is induced by different agents with low toxicity and more specificity than traditional ones. Diosgenin, a plant steroid, is able to induce megakaryocytic differentiation or apoptosis in human HEL ...
Lamia Ghezali +4 more
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Cells, 2022 The Hedgehog signaling pathway regulates many processes during embryogenesis and the homeostasis of adult organs. Recent data suggest that central metabolic processes and signaling cascades in the liver are controlled by the Hedgehog pathway and that ...
Fritzi Ott +12 more
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Hedgehog signaling pathway as a potential target in the treatment of advanced gastric cancer
Tumor Biology, 2017 The sonic hedgehog signaling pathway is critical for cell proliferation, cell differentiation, and organ development during embryogenesis. Aberrant activation of the sonic hedgehog pathway has been associated with a variety of human cancers.
Dae-Hee Lee +2 more
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Activation of the hedgehog pathway in advanced prostate cancer
Molecular Cancer, 2004 Background The hedgehog pathway plays a critical role in the development of prostate. However, the role of the hedgehog pathway in prostate cancer is not clear. Prostate cancer is the second most prevalent cause of cancer death in American men. Therefore,
McCormick Frank +8 more
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The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo
Communications Biology, 2021 By modulating the activation state of the Hedgehog pathway, de la Rocha-Muñoz et al demonstrate that Hedgehog signaling controls the expression and transport activity of the neuronal glycine transporter GlyT2.
Andrés de la Rocha-Muñoz +8 more
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Hedgehog Pathway Blockade Inhibits Melanoma Cell Growth in Vitro and in Vivo
Pharmaceuticals, 2013 Previous reports have demonstrated a role for hedgehog signaling in melanoma progression, prompting us to explore the therapeutic benefit of targeting this pathway in melanoma.
Eva Hernando +10 more
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Hedgehog Signaling and Embryonic Craniofacial Disorders
Journal of Developmental Biology, 2019 Since its initial discovery in a Drosophila mutagenesis screen, the Hedgehog pathway has been revealed to be instrumental in the proper development of the vertebrate face. Vertebrates possess three hedgehog paralogs: Sonic hedgehog (Shh), Indian hedgehog
John Abramyan
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Hedgehog inhibition promotes a switch from Type II to Type I cell death receptor signaling in cancer cells. [PDF]
PLoS ONE, 2011 TRAIL is a promising therapeutic agent for human malignancies. TRAIL often requires mitochondrial dysfunction, referred to as the Type II death receptor pathway, to promote cytotoxicity.
Satoshi Kurita +8 more
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