Results 91 to 100 of about 100,157 (319)

MicroRNAs-Proteomic Networks Characterizing Human Medulloblastoma-SLCs [PDF]

, 2016
Medulloblastoma (MB) is the most common malignant brain tumor of pediatric age and is characterized by cells expressing stem, astroglial, and neuronal markers.
Alfano, Vincenzo, Besharat, ZEIN MERSINI, Carai, Andrea, Catanzaro, Giuseppina, Ferretti, Elisabetta, Garg, Neha, Locatelli, Franco, Mastronuzzi, Angela, Miele, Evelina, Pieroni, Luisa, Po, Agnese, Ronci, Maurizio, Screpanti, Isabella, Urbani, Andrea   +13 more
core   +4 more sources

SNORA74A Drives Self‐Renewal of Liver Cancer Stem Cells and Hepatocarcinogenesis Through Activation of Notch3 Signaling

Advanced Science, EarlyView.
Abstract Liver cancer stem cells (CSCs) account for tumor initiation, heterogeneity and therapy resistance. However, the role of small nucleolar RNAs (snoRNAs) in the regulation of liver CSCs remains largely unclear. Here, this work identifies a conserved H/ACA box snoRNA SNORA74A which is highly expressed in liver CSCs.
Ziheng Zhou, Yang Gu, Zhibin Yi, Jianyi Wang, Zhen Xiong, Hui Guo, Ying Du, Xiaoxiao Zhu, Lei He, Weizheng Ren, Yong Tian, Yanying Wang, Zusen Fan   +12 more
wiley   +1 more source

Smooth Combs Inside Hedgehogs [PDF]

arXiv, 2009
We use techniques of tube-log Riemann surfaces due to R.Perez-Marco to construct a hedgehog containing smooth $C^{\infty}$ combs. The hedgehog is a common hedgehog for a family of commuting non-linearisable holomorphic maps with a common indifferent fixed point. The comb is made up of smooth curves, and is transversally bi-H\"older regular.
arxiv  

The Role of GLI-1 in Endocrine Resistant Breast Cancer [PDF]

, 2014
Estrogen receptor positive (ER+) and estrogen receptor negative (ER-) are two major types of breast cancer. For women with ER+ positive breast cancer, patients are treated with the antiestrogenic compounds, tamoxifen or faslodex for five years ...
Rudolph, Mark
core  

Worth the Effort: Lessons for Discovery and Care From an Unusual Case of Gorlin Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Gorlin‐Goltz Syndrome (GGS) is a rare autosomal dominant genetic disorder encompassing a diverse range of clinical manifestations, including congenital anomalies and predisposition to cancer. Pathogenic variants in PTCH1 and SUFU account for up to 79% and 6% of cases, respectively. Currently, an estimated 15%–27% of individuals with a clinical
V. Taliercio, J. Zhao, S. E. Boyden, R. Mao, P. Bayrak‐Toydemir, A. Pflaum, J. Palumbos, A. Andrews, E. E. Baldwin, C. Welt, Mackenzie Fait, Undiagnosed Diseases Network, L. D. Botto, D. Viskochil   +13 more
wiley   +1 more source

Long-Noncoding RNA ANCR Activates the Hedgehog Signaling Pathway to Promote Basal Cell Carcinoma Progression by Binding to PTCH

Clinical, Cosmetic and Investigational Dermatology, 2022
Hongxuan Wu,* Pingxiu He,* Dong Xie, Jianqiao Wang, Chuan Wan Department of Dermatology, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, People’s Republic of China*These authors contributed equally to this ...
Wu H, He P, Xie D, Wang J, Wan C
doaj  

Decoding regulatory programs underlying placode and dermal condensate cell fate commitment during hair follicle induction via single‐cell multi‐omics analysis

Animal Research and One Health, EarlyView.
The experimental framework of the study encompasses sample collection, single‐cell data analysis, and experimental validation. Abstract Understanding differences in chromatin state and changes in gene regulatory landscape of placode (Pc) and dermal condensate are crucial for decoding hair follicle (HF) morphogenesis programs.
Fang Li, Minghao Li, Tongtong Zhang, Menghua Sui, Hasan Khatib, Xin Wang   +5 more
wiley   +1 more source

Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis

Neoplasia: An International Journal for Oncology Research, 2017
Medulloblastoma is the most common malignant brain tumor in children. Therapeutic approaches to medulloblastoma (combination of surgery, radiotherapy, and chemotherapy) have led to significant improvements, but these are achieved at a high cost to ...
Tao Xu, Honglai Zhang, Sung-Soo Park, Sriram Venneti, Rork Kuick, Kimberly Ha, Lowell Evan Michael, Mariarita Santi, Chiyoko Uchida, Takafumi Uchida, Ashok Srinivasan, James M. Olson, Andrzej A. Dlugosz, Sandra Camelo-Piragua, Jean-François Rual   +14 more
doaj  

Characterizing hedgehog pathway features in senescence associated osteoarthritis through Integrative multi-omics and machine learning analysis

Frontiers in Genetics
Purpose: Osteoarthritis (OA) is a disease of senescence and inflammation. Hedgehog’s role in OA mechanisms is unclear. This study combines Bulk RNA-seq and scRNA-seq to identify Hedgehog-associated genes in OA, investigating their impact on the ...
Tao Wang, Zhengrui Li, Shijian Zhao, Ying Liu, Wenliang Guo, Raquel Alarcòn Rodrìguez, Yinteng Wu, Ruqiong Wei   +7 more
doaj   +1 more source

The Radial-Hedgehog Solution in Landau--de Gennes' theory [PDF]

arXiv, 2010
We study the radial-hedgehog solution in a three-dimensional spherical droplet, with homeotropic boundary conditions, within the Landau-de Gennes theory for nematic liquid crystals. The radial-hedgehog solution is a candidate for a globally stable configuration in this model framework and is also a prototype configuration for studying isolated point ...
arxiv