Results 91 to 100 of about 93,686 (252)

Endothelial to mesenchymal transition (EndoMT) in the pathogenesis of Systemic Sclerosis-associated pulmonary fibrosis and pulmonary arterial hypertension. Myth or reality? [PDF]

, 2016
Systemic Sclerosis (SSc) is a systemic autoimmune disease characterized by progressive fibrosis of skin and multiple internal organs and severe functional and structural microvascular alterations.
Jimenez, Sergio A., Piera-Velazquez, Sonsoles   +1 more
core   +2 more sources

RETRACTED ARTICLE: mTORC2 regulates hedgehog pathway activity by promoting stability to Gli2 protein and its nuclear translocation

Cell Death and Disease, 2017
mTORC2 is aberrantly activated in cancer and therefore is considered to be an important therapeutic target. The hedgehog pathway, which is also often hyperactivated, regulates transcription of several genes associated with angiogenesis, metastasis ...
Samarpan Maiti, Susmita Mondal, Eswara M Satyavarapu, Chitra Mandal   +3 more
doaj   +1 more source

The ciliary GTPase Arl13b regulates cell migration and cell cycle progression [PDF]

, 2016
Acknowledgments We acknowledge Prof. Tamara Caspary from Emory University for kindly providing the cell lines, Linda Duncan from the University of Aberdeen Ian Fraser Cytometry Center for help with flow cytometry.
Clancy, Hannah, Ding, Yu-Qiang, Lang, Bing, McCaig, Colin D., Pruski, Michal, Rajnicek, Ann, Yang, Zhifu   +6 more
core   +2 more sources

Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis

Biochemistry, 2020
Hedgehog proteins, a family of vital cell signaling factors, are expressed in precursor form, which requires specialized autoprocessing, called cholesterolysis, for full biological activity. Cholesterolysis occurs in cis through the action of the precursor's C-terminal enzymatic domain, HhC.
Carl J. Smith, Andrew G. Wagner, Robert T. Stagnitta, Zihan Xu, John L. Pezzullo, José-Luis Giner, Jian Xie, Douglas F. Covey, Chunyu Wang, Brian P. Callahan   +9 more
openaire   +3 more sources

Computational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factors.

PLoS Computational Biology, 2010
In order to fully understand protein kinase networks, new methods are needed to identify regulators and substrates of kinases, especially for weakly expressed proteins.
Thomas C Whisenant, David T Ho, Ryan W Benz, Jeffrey S Rogers, Robyn M Kaake, Elizabeth A Gordon, Lan Huang, Pierre Baldi, Lee Bardwell   +8 more
doaj   +1 more source

In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors. [PDF]

, 2016
Aberrant Hedgehog (Hh)/glioma-associated oncogene (GLI) signaling has been implicated in cancer progression. Here, we analyzed GLI1, Sonic Hedgehog (Shh) and NF-κB expression in 51 breast cancer (ductal carcinoma) tissues using immunohistochemistry ...
Bei, R., Benvenuto, M, Bonanno, E, Cucchi, Danilo, DE SMAELE, Enrico, DI STEFANO, Enrica, Fantini, M, Frajese, Gv, Gulino, Alberto, Masuelli, Laura, Mattera, Rosanna, Modesti, A, Orlandi, A, Screpanti, Isabella   +13 more
core   +1 more source

Sonic hedgehog pathway expression in non-small cell lung cancer

Therapeutic Advances in Medical Oncology, 2012
Objective: Activation of the hedgehog pathway is an important signaling mechanism crucial in embryogenesis and has strong links to carcinogenesis. This study investigates the expression of the Sonic hedgehog pathway molecules in non-small cell lung ...
Malvi Savani, Yan Guo, David P. Carbone, Ildiko Csiki   +3 more
doaj   +1 more source

Branch Mode Selection during Early Lung Development [PDF]

, 2012
Many organs of higher organisms, such as the vascular system, lung, kidney, pancreas, liver and glands, are heavily branched structures. The branching process during lung development has been studied in great detail and is remarkably stereotyped.
A Kicheva, A Weddemann, A White, AA Mailleux, AC White, AD Bragg, AJ Bard, B Hebert, B West, B Xu, BA Hyatt, BA Hyatt, C Chiang, C Nelson, Conradin Kraemer, CV Pepicelli, D Hartmann, D Hartmann, D Lebeche, D Warburton, Dagmar Iber, Denis Menshykau, E Crampin, E Domyan, E Weibel, Edmund J. Crampin, G Carraro, H Kitaoka, H Kitaoka, H Min, IJ Cutress, IV Nesmelova, J Maina, J Motoyama, J Murray, J Ries, J Sharpe, JA Goetz, JC Clark, K Sekine, KA Moore, KM Short, LAD Miller, LL Abler, LV Goodrich, M Affolter, M Carin, M Kumar, M Unbekandt, M Weaver, M Weaver, MC Eblaghie, MC Eblaghie, N Gjorevski, N Kim, P Chuang, P Nyeng, PM Lewis, R Aris, R Vuilleumier, RJ Metzger, RJ Metzger, RS Moura, RW Glenny, S Bellusci, S Bellusci, S Bellusci, S Bellusci, S Kondo, S Lubkin, S Lubkin, S Malpel, SK Ramasamy, SR Yu, T Bollenbach, T Hirashima, T Miura, T Miura, T Nelson, T Okubo, T Wilson, TM Moore, TR Nelson, U Frey, V Thummler, W Cardoso, WV Cardoso, X Wan, Y Litingtung   +88 more
core   +6 more sources

Lipoprotein[a] is the major apoB-containing lipoprotein in the plasma of a hibernator, the hedgehog (Erinaceus europaeus).

Journal of Lipid Research, 1988
We have undertaken studies aimed at elucidating the interrelationships existing between the seasonal modifications in endocrine status (already demonstrated by Saboureau, M., and J. Boissin. 1978. C.R. Acad. Sci.
P M Laplaud, L Beaubatie, S C Rall, Jr, G Luc, M Saboureau   +4 more
doaj   +1 more source

The Proteasome and Cul3-Dependent Protein Ubiquitination Is Required for Gli Protein-Mediated Activation of Gene Expression in the Hedgehog Pathway

Cells
Many cellular processes are regulated by proteasome-mediated protein degradation, including regulation of signaling pathways and gene expression. Among the pathways regulated by the ubiquitin–proteasome system is the Hedgehog pathway and its downstream ...
Tomasz Uśpieński, Paweł Niewiadomski
doaj   +1 more source