Results 91 to 100 of about 1,401 (218)

Sonic Hedgehog–Regulated Oligodendrocyte Lineage Genes Encoding bHLH Proteins in the Mammalian Central Nervous System [PDF]

, 2000
Q. Richard Lu, Dong-in Yuk, John A. Alberta, Zhimin Zhu, Inka Pawlitzky, Joanne Chan, Andrew P. McMahon, Charles D. Stiles, David H. Rowitch   +8 more
openalex   +1 more source

Molecular anatomy of emerging Xenopus left–right organizer at successive developmental stages

Developmental Dynamics, EarlyView.
Abstract Background Vertebrate left–right symmetry breaking is preceded by formation of left–right organizer. In Amphibian, this structure is formed by gastrocoel roof plate, which emerges from superficial suprablastoporal cells. GRP is subdivided into medial area, which generates leftward flow by rotating monocilia and lateral Nodal1 expressing areas,
Natalia Petri, Alexandra Vetrova, Nikoloz Tsikolia, Stanislav Kremnyov   +3 more
wiley   +1 more source

Expression of Indian Hedgehog, Parathyroid Hormone-Related Protein, and Their Receptors in the Postnatal Growth Plate of the Rat: Evidence for a Locally Acting Growth Restraining Feedback Loop After Birth [PDF]

, 2000
Bram C. J. van der Eerden, Marcel Karperien, Evelien Gevers, Clemens W. G. M. Löwik, Jan M. Wit   +4 more
openalex   +1 more source

BMP4 regulates asymmetric Pkd2 distribution in mouse nodal immotile cilia and ciliary mechanosensing required for left–right determination

Developmental Dynamics, EarlyView.
Abstract Background Mouse nodal immotile cilia mechanically sense the bending direction for left–right (L–R) determination and activate the left‐side‐specific signaling cascade, leading to increased Nodal activity. Asymmetric distribution of Pkd2, a crucial channel for L–R determination, on immotile cilia has been reported recently. However, the causal
Takanobu A. Katoh, Tim Lange, Yoshiro Nakajima, Kenta Yashiro, Yasushi Okada, Hiroshi Hamada   +5 more
wiley   +1 more source

Hedgehog components are overexpressed in a series of liver cancer cases

Scientific Reports
Liver cancers, including hepatocellular carcinoma (HCC), are the sixth most common cancer and the third leading cause of cancer-related death worldwide, representing a global public health problem. This study evaluated nine patients with HCC.
Caroline Brandi Schlaepfer Sales, Rosane Borges Dias, Ludmila de Faro Valverde, Larissa M. Bomfim, Lais Almeida Silva, Nanashara C. de Carvalho, Jorge Luiz Andrade Bastos, Tatiana Martins Tilli, Gisele Vieira Rocha, Milena Botelho Pereira Soares, Luiz Antonio Rodrigues de Freitas, Clarissa A. Gurgel Rocha, Daniel P. Bezerra   +12 more
doaj   +1 more source

Saikosaponin b1 Attenuates Liver Fibrosis by Blocking STAT3/Gli1 Interaction and Inducing Gli1 Degradation

Exploration, EarlyView.
Saikosaponin b1 attenuates liver fibrosis by competitively disrupting the interaction between signal transducer and activator of transcription 3 (STAT3) and glioma‐associated oncogene‐1 (Gli1) in the activated hepatic stellate cells (HSCs). The blocked interaction of STAT3 and Gli1 promotes the degradation of Gli1, inhibits Gli1 transcriptional ...
Meiyu Shao, Xiaoqing Zhang, Jiamei Sun, Hongyan Dong, Xin Han, Qiao Yang, Roufen Chen, Liteng Shen, Lei Xu, Lu Wang, Bo Zhu, Dongxin Tang, Shuosheng Zhang, Keda Lu, Mengyun Peng, Gang Cao   +15 more
wiley   +1 more source

Dispatched protein releases Hedgehog from cells [PDF]

, 2000
Alan D. Shirras
openalex   +1 more source

Glia Preserve Their Own Functions While Compensating for Neighboring Glial Cell Dysfunction

Glia, EarlyView.
When cortex glia lose their interactions with neuronal cell bodies, all neighboring glia infiltrate the region to clear extra neuronal corpses. Even while compensating for nearby glial dysfunction, glia maintain their own phagocytic functions. ABSTRACT Glial cells are essential for nervous system development, homeostasis, and disease response, engaging
Allison N. Beachum, Gabriela Salazar, Amelia Nachbar, Kevin Krause, Hannah Klose, Kate Meyer, Ariana Maserejian, Grace Ross, Hannah Boyd, Thaddeus Weigel, Lydia Ambaye, Hayes Miller, Hannah Grote, Jaeda Coutinho‐Budd   +13 more
wiley   +1 more source

Itraconazole promotes melanoma cells apoptosis via inhibiting hedgehog signaling pathway-mediated autophagy

Frontiers in Pharmacology
BackgroundItraconazole, a widely used antifungal medication, has shown potential in inhibiting tumor growth and reducing angiogenesis. However, its role in melanoma tumor growth remains insufficiently explored.
Shunqiao Jin, Shunqiao Jin, Xiaojiao Liu, Xiaojiao Liu, Lingqin Cai, Lingqin Cai, Jiayu Yan, Ling Li, Hongjun Dong, Yuxue Gao, Xicong Zhu, Cong Zhang, Xuezhu Xu   +12 more
doaj   +1 more source

Hedgehog Signaling Regulation of Homeodomain Protein Islet Duodenum Homeobox-1 Expression in Pancreatic -Cells [PDF]

, 2001
Melissa K. Thomas
openalex   +1 more source